Cardiac Involvement Due to COVID-19: Insights from Imaging and Histopathology
Lingering cardiac symptoms are increasingly recognised complications of severe acute respiratory syndrome coronavirus 2 infection, now referred to as post-acute cardiovascular sequelae of COVID-19 (PASC). In the acute phase, cardiac injury is driven by cytokine release and stems from ischaemic and t...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2023-10-01
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| Series: | European Cardiology Review |
| Online Access: | https://www.ecrjournal.com/articleindex/ecr.2023.02 |
| _version_ | 1797199978743988224 |
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| author | Valentina O Puntmann Anastasia Shchendrygina Carlos Rodriguez Bolanos Mame Madjiguène Ka Silvia Valbuena Andreas Rolf Felicitas Escher Eike Nagel |
| author_facet | Valentina O Puntmann Anastasia Shchendrygina Carlos Rodriguez Bolanos Mame Madjiguène Ka Silvia Valbuena Andreas Rolf Felicitas Escher Eike Nagel |
| author_sort | Valentina O Puntmann |
| collection | DOAJ |
| description | Lingering cardiac symptoms are increasingly recognised complications of severe acute respiratory syndrome coronavirus 2 infection, now referred to as post-acute cardiovascular sequelae of COVID-19 (PASC). In the acute phase, cardiac injury is driven by cytokine release and stems from ischaemic and thrombotic complications, resulting in myocardial necrosis. Patients with pre-existing cardiac conditions are particularly vulnerable. Myocarditis due to a direct viral infection is rare. Chronic symptoms relate to either worsening of pre-existing heart disease (PASC – cardiovascular disease) or delayed chronic inflammatory condition due to heterogenous immune dysregulation (PASC – cardiovascular syndrome), the latter affecting a broad segment of previously well people. Both PASC presentations are associated with increased cardiovascular risk, long-term disability and reduced quality of life. The recognition and management of PASC in clinical settings remains a considerable challenge. Sensitive diagnostic methods are needed to detect subtler inflammatory changes that underlie the persistent symptoms in PASC – cardiovascular syndrome, alongside considerable clinical experience in inflammatory cardiac conditions. |
| first_indexed | 2024-03-07T17:38:52Z |
| format | Article |
| id | doaj.art-4b394534420646b5b414130cc67cab85 |
| institution | Directory Open Access Journal |
| issn | 1758-3756 1758-3764 |
| language | English |
| last_indexed | 2024-04-24T07:24:21Z |
| publishDate | 2023-10-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | European Cardiology Review |
| spelling | doaj.art-4b394534420646b5b414130cc67cab852024-04-20T16:03:42ZengRadcliffe Medical MediaEuropean Cardiology Review1758-37561758-37642023-10-011810.15420/ecr.2023.02Cardiac Involvement Due to COVID-19: Insights from Imaging and HistopathologyValentina O Puntmann0Anastasia Shchendrygina1Carlos Rodriguez Bolanos2Mame Madjiguène Ka3Silvia Valbuena4Andreas Rolf5Felicitas Escher6Eike Nagel7Institute for Experimental and Translational Cardiovascular Imaging, DZHK Centre for Cardiovascular Imaging, Goethe University Frankfurt, Frankfurt am Main, GermanyInstitute for Experimental and Translational Cardiovascular Imaging, DZHK Centre for Cardiovascular Imaging, Goethe University Frankfurt, Frankfurt am Main, GermanyInstitute for Experimental and Translational Cardiovascular Imaging, DZHK Centre for Cardiovascular Imaging, Goethe University Frankfurt, Frankfurt am Main, GermanyInstitute for Experimental and Translational Cardiovascular Imaging, DZHK Centre for Cardiovascular Imaging, Goethe University Frankfurt, Frankfurt am Main, GermanyDepartment of Cardiology, University Hospital La Paz, Madrid, SpainDepartment of Cardiology, Campus Kerckhoff of Justus-Liebig-University Giessen, Bad Nauheim, GermanyInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, Berlin, GermanyInstitute for Experimental and Translational Cardiovascular Imaging, DZHK Centre for Cardiovascular Imaging, Goethe University Frankfurt, Frankfurt am Main, GermanyLingering cardiac symptoms are increasingly recognised complications of severe acute respiratory syndrome coronavirus 2 infection, now referred to as post-acute cardiovascular sequelae of COVID-19 (PASC). In the acute phase, cardiac injury is driven by cytokine release and stems from ischaemic and thrombotic complications, resulting in myocardial necrosis. Patients with pre-existing cardiac conditions are particularly vulnerable. Myocarditis due to a direct viral infection is rare. Chronic symptoms relate to either worsening of pre-existing heart disease (PASC – cardiovascular disease) or delayed chronic inflammatory condition due to heterogenous immune dysregulation (PASC – cardiovascular syndrome), the latter affecting a broad segment of previously well people. Both PASC presentations are associated with increased cardiovascular risk, long-term disability and reduced quality of life. The recognition and management of PASC in clinical settings remains a considerable challenge. Sensitive diagnostic methods are needed to detect subtler inflammatory changes that underlie the persistent symptoms in PASC – cardiovascular syndrome, alongside considerable clinical experience in inflammatory cardiac conditions.https://www.ecrjournal.com/articleindex/ecr.2023.02 |
| spellingShingle | Valentina O Puntmann Anastasia Shchendrygina Carlos Rodriguez Bolanos Mame Madjiguène Ka Silvia Valbuena Andreas Rolf Felicitas Escher Eike Nagel Cardiac Involvement Due to COVID-19: Insights from Imaging and Histopathology European Cardiology Review |
| title | Cardiac Involvement Due to COVID-19: Insights from Imaging and Histopathology |
| title_full | Cardiac Involvement Due to COVID-19: Insights from Imaging and Histopathology |
| title_fullStr | Cardiac Involvement Due to COVID-19: Insights from Imaging and Histopathology |
| title_full_unstemmed | Cardiac Involvement Due to COVID-19: Insights from Imaging and Histopathology |
| title_short | Cardiac Involvement Due to COVID-19: Insights from Imaging and Histopathology |
| title_sort | cardiac involvement due to covid 19 insights from imaging and histopathology |
| url | https://www.ecrjournal.com/articleindex/ecr.2023.02 |
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