Acquisition Parameters Influence Diffusion Metrics Effectiveness in Probing Prostate Tumor and Age-Related Microstructure
This study aimed to investigate the Diffusion-Tensor-Imaging (DTI) potential in the detection of microstructural changes in prostate cancer (PCa) in relation to the diffusion weight (b-value) and the associated diffusion length l<sub>D</sub>. Thirty-two patients (age range = 50–87 years)...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/5/860 |
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| author | Alessandra Stella Caporale Marco Nezzo Maria Giovanna Di Trani Alessandra Maiuro Roberto Miano Pierluigi Bove Alessandro Mauriello Guglielmo Manenti Silvia Capuani |
| author_facet | Alessandra Stella Caporale Marco Nezzo Maria Giovanna Di Trani Alessandra Maiuro Roberto Miano Pierluigi Bove Alessandro Mauriello Guglielmo Manenti Silvia Capuani |
| author_sort | Alessandra Stella Caporale |
| collection | DOAJ |
| description | This study aimed to investigate the Diffusion-Tensor-Imaging (DTI) potential in the detection of microstructural changes in prostate cancer (PCa) in relation to the diffusion weight (b-value) and the associated diffusion length l<sub>D</sub>. Thirty-two patients (age range = 50–87 years) with biopsy-proven PCa underwent Diffusion-Weighted-Imaging (DWI) at 3T, using single non-zero b-value or groups of b-values up to b = 2500 s/mm<sup>2</sup>. The DTI maps (mean-diffusivity, MD; fractional-anisotropy, FA; axial and radial diffusivity, D// and D┴), visual quality, and the association between DTI-metrics and Gleason Score (GS) and DTI-metrics and age were discussed in relation to diffusion compartments probed by water molecules at different b-values. DTI-metrics differentiated benign from PCa tissue (<i>p</i> ≤ 0.0005), with the best discriminative power versus GS at b-values ≥ 1500 s/mm<sup>2</sup>, and for b-values range 0–2000 s/mm<sup>2</sup>, when the l<sub>D</sub> is comparable to the size of the epithelial compartment. The strongest linear correlations between MD, D//, D┴, and GS were found at b = 2000 s/mm<sup>2</sup> and for the range 0–2000 s/mm<sup>2</sup>. A positive correlation between DTI parameters and age was found in benign tissue. In conclusion, the use of the b-value range 0–2000 s/mm<sup>2</sup> and b-value = 2000 s/mm<sup>2</sup> improves the contrast and discriminative power of DTI with respect to PCa. The sensitivity of DTI parameters to age-related microstructural changes is worth consideration. |
| first_indexed | 2024-03-11T03:35:23Z |
| format | Article |
| id | doaj.art-4b39d93f21f24960ad92b3003c155ad9 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T03:35:23Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-4b39d93f21f24960ad92b3003c155ad92023-11-18T02:05:11ZengMDPI AGJournal of Personalized Medicine2075-44262023-05-0113586010.3390/jpm13050860Acquisition Parameters Influence Diffusion Metrics Effectiveness in Probing Prostate Tumor and Age-Related MicrostructureAlessandra Stella Caporale0Marco Nezzo1Maria Giovanna Di Trani2Alessandra Maiuro3Roberto Miano4Pierluigi Bove5Alessandro Mauriello6Guglielmo Manenti7Silvia Capuani8Department of Neuroscience, Imaging and Clinical Sciences, ‘G. d’Annunzio’ University of Chieti-Pescara, 66100 Chieti, ItalyInterventional Radiology Unit, Department of Biomedicine and Prevention, Tor Vergata University of Rome, 00133 Rome, ItalyCentro Fermi–Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi, 00184 Rome, ItalyCNR ISC, c/o Physics Department, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyDivision of Urology, Department of Surgical Sciences, Tor Vergata University of Rome, 00133 Rome, ItalyDivision of Urology, Department of Surgical Sciences, Tor Vergata University of Rome, 00133 Rome, ItalyAnatomic Pathology, Department of Experimental Medicine, PTV Foundation, Tor Vergata University of Rome, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, UOC Radiology PTV Foundation, Tor Vergata University of Rome, 00133 Rome, ItalyCNR ISC, c/o Physics Department, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyThis study aimed to investigate the Diffusion-Tensor-Imaging (DTI) potential in the detection of microstructural changes in prostate cancer (PCa) in relation to the diffusion weight (b-value) and the associated diffusion length l<sub>D</sub>. Thirty-two patients (age range = 50–87 years) with biopsy-proven PCa underwent Diffusion-Weighted-Imaging (DWI) at 3T, using single non-zero b-value or groups of b-values up to b = 2500 s/mm<sup>2</sup>. The DTI maps (mean-diffusivity, MD; fractional-anisotropy, FA; axial and radial diffusivity, D// and D┴), visual quality, and the association between DTI-metrics and Gleason Score (GS) and DTI-metrics and age were discussed in relation to diffusion compartments probed by water molecules at different b-values. DTI-metrics differentiated benign from PCa tissue (<i>p</i> ≤ 0.0005), with the best discriminative power versus GS at b-values ≥ 1500 s/mm<sup>2</sup>, and for b-values range 0–2000 s/mm<sup>2</sup>, when the l<sub>D</sub> is comparable to the size of the epithelial compartment. The strongest linear correlations between MD, D//, D┴, and GS were found at b = 2000 s/mm<sup>2</sup> and for the range 0–2000 s/mm<sup>2</sup>. A positive correlation between DTI parameters and age was found in benign tissue. In conclusion, the use of the b-value range 0–2000 s/mm<sup>2</sup> and b-value = 2000 s/mm<sup>2</sup> improves the contrast and discriminative power of DTI with respect to PCa. The sensitivity of DTI parameters to age-related microstructural changes is worth consideration.https://www.mdpi.com/2075-4426/13/5/860prostateDTIGleason scoreagingb-valuediffusion length |
| spellingShingle | Alessandra Stella Caporale Marco Nezzo Maria Giovanna Di Trani Alessandra Maiuro Roberto Miano Pierluigi Bove Alessandro Mauriello Guglielmo Manenti Silvia Capuani Acquisition Parameters Influence Diffusion Metrics Effectiveness in Probing Prostate Tumor and Age-Related Microstructure Journal of Personalized Medicine prostate DTI Gleason score aging b-value diffusion length |
| title | Acquisition Parameters Influence Diffusion Metrics Effectiveness in Probing Prostate Tumor and Age-Related Microstructure |
| title_full | Acquisition Parameters Influence Diffusion Metrics Effectiveness in Probing Prostate Tumor and Age-Related Microstructure |
| title_fullStr | Acquisition Parameters Influence Diffusion Metrics Effectiveness in Probing Prostate Tumor and Age-Related Microstructure |
| title_full_unstemmed | Acquisition Parameters Influence Diffusion Metrics Effectiveness in Probing Prostate Tumor and Age-Related Microstructure |
| title_short | Acquisition Parameters Influence Diffusion Metrics Effectiveness in Probing Prostate Tumor and Age-Related Microstructure |
| title_sort | acquisition parameters influence diffusion metrics effectiveness in probing prostate tumor and age related microstructure |
| topic | prostate DTI Gleason score aging b-value diffusion length |
| url | https://www.mdpi.com/2075-4426/13/5/860 |
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