Risk Factors for Cryptococcus gattii Infection, British Columbia, Canada
To determine whether particular environmental, medical, or behavioral risk factors existed among Cryptcoccus gattii–infected persons compared with the general population, we conducted a sex-matched case−control study on a subset of case-patients in British Columbia (1999–2001). Exposures and underly...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2011-02-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/17/2/10-1020_article |
| _version_ | 1828974043078852608 |
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| author | Laura MacDougall Murray Fyfe Marc Romney Mike Starr Eleni Galanis |
| author_facet | Laura MacDougall Murray Fyfe Marc Romney Mike Starr Eleni Galanis |
| author_sort | Laura MacDougall |
| collection | DOAJ |
| description | To determine whether particular environmental, medical, or behavioral risk factors existed among Cryptcoccus gattii–infected persons compared with the general population, we conducted a sex-matched case−control study on a subset of case-patients in British Columbia (1999–2001). Exposures and underlying medical conditions among all case-patients (1999–2007) were also compared with results of provincial population–based surveys and studies. In case−control analyses, oral steroids (matched odds ratio [MOR] 8.11, 95% confidence interval [CI] 1.74–37.80), pneumonia (MOR 2.71, 95% CI 1.05–6.98), and other lung conditions (MOR 3.21, 95% CI 1.08–9.52) were associated with infection. In population comparisons, case-patients were more likely to be >50 years of age (p<0.001), current smokers (p<0.001), infected with HIV (p<0.001), or have a history of invasive cancer (p<0.001). Although C. gattii is commonly believed to infect persons with apparently healthy immune systems, several immunosuppressive and pulmonary conditions seem to be risk factors. |
| first_indexed | 2024-12-14T13:55:20Z |
| format | Article |
| id | doaj.art-4b3a56ec386340c49760a63d477cd220 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-14T13:55:20Z |
| publishDate | 2011-02-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-4b3a56ec386340c49760a63d477cd2202022-12-21T22:58:52ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592011-02-0117219319910.3201/eid1702.101020Risk Factors for Cryptococcus gattii Infection, British Columbia, CanadaLaura MacDougallMurray FyfeMarc RomneyMike StarrEleni GalanisTo determine whether particular environmental, medical, or behavioral risk factors existed among Cryptcoccus gattii–infected persons compared with the general population, we conducted a sex-matched case−control study on a subset of case-patients in British Columbia (1999–2001). Exposures and underlying medical conditions among all case-patients (1999–2007) were also compared with results of provincial population–based surveys and studies. In case−control analyses, oral steroids (matched odds ratio [MOR] 8.11, 95% confidence interval [CI] 1.74–37.80), pneumonia (MOR 2.71, 95% CI 1.05–6.98), and other lung conditions (MOR 3.21, 95% CI 1.08–9.52) were associated with infection. In population comparisons, case-patients were more likely to be >50 years of age (p<0.001), current smokers (p<0.001), infected with HIV (p<0.001), or have a history of invasive cancer (p<0.001). Although C. gattii is commonly believed to infect persons with apparently healthy immune systems, several immunosuppressive and pulmonary conditions seem to be risk factors.https://wwwnc.cdc.gov/eid/article/17/2/10-1020_articleCryptococcus neoformansCryptococcus gattiicryptococcosisrespiratory infectionfungiparasites |
| spellingShingle | Laura MacDougall Murray Fyfe Marc Romney Mike Starr Eleni Galanis Risk Factors for Cryptococcus gattii Infection, British Columbia, Canada Emerging Infectious Diseases Cryptococcus neoformans Cryptococcus gattii cryptococcosis respiratory infection fungi parasites |
| title | Risk Factors for Cryptococcus gattii Infection, British Columbia, Canada |
| title_full | Risk Factors for Cryptococcus gattii Infection, British Columbia, Canada |
| title_fullStr | Risk Factors for Cryptococcus gattii Infection, British Columbia, Canada |
| title_full_unstemmed | Risk Factors for Cryptococcus gattii Infection, British Columbia, Canada |
| title_short | Risk Factors for Cryptococcus gattii Infection, British Columbia, Canada |
| title_sort | risk factors for cryptococcus gattii infection british columbia canada |
| topic | Cryptococcus neoformans Cryptococcus gattii cryptococcosis respiratory infection fungi parasites |
| url | https://wwwnc.cdc.gov/eid/article/17/2/10-1020_article |
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