Sarmentosamide, an Anti-Aging Compound from a Marine-Derived <i>Streptomyces</i> sp. APmarine042
Many bioactive materials have been isolated from marine microorganisms, including alkaloids, peptides, lipids, mycosporine-like amino acids, glycosides, and isoprenoids. Some of these compounds have great potential in the cosmetic industry due to their photo-protective, anti-aging, and anti-oxidant...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/18/9/463 |
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| author | Eun-Soo Lee Eun-Young Lee Jisoo Yoon Ahreum Hong Sang-Jip Nam Jaeyoung Ko |
| author_facet | Eun-Soo Lee Eun-Young Lee Jisoo Yoon Ahreum Hong Sang-Jip Nam Jaeyoung Ko |
| author_sort | Eun-Soo Lee |
| collection | DOAJ |
| description | Many bioactive materials have been isolated from marine microorganisms, including alkaloids, peptides, lipids, mycosporine-like amino acids, glycosides, and isoprenoids. Some of these compounds have great potential in the cosmetic industry due to their photo-protective, anti-aging, and anti-oxidant activities. In this study, sarmentosamide (<b>1</b>) was isolated from marine-derived <i>Streptomyces</i> sp. APmarine042, after which its capacity to decrease skin aging was examined in-vitro. Sarmentosamide (<b>1</b>) was found to significantly reduce UVB-induced matrix metalloproteinase-1 (MMP-1) expression in normal human dermal fibroblasts (NHDFs) by inhibiting the extracellular signal-regulated kinase (ERK) and the c-Jun N-terminal kinase (JNK) phosphorylation, which are regulatory pathways upstream of MMP-1 transcription. Additionally, we confirmed that sarmentosamide (<b>1</b>) decreased tumor necrosis factor-alpha (TNF-α), induced MMP-1 secretion in NHDFs, and exhibited free-radical scavenging activity, as demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Therefore, our study suggests that sarmentosamide (<b>1</b>) could be a promising anti-aging agent that acts via the downregulation of MMP-1 expression. |
| first_indexed | 2024-03-10T16:25:23Z |
| format | Article |
| id | doaj.art-4b3aa409d9734912b2d1bba1c211e549 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T16:25:23Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-4b3aa409d9734912b2d1bba1c211e5492023-11-20T13:18:18ZengMDPI AGMarine Drugs1660-33972020-09-0118946310.3390/md18090463Sarmentosamide, an Anti-Aging Compound from a Marine-Derived <i>Streptomyces</i> sp. APmarine042Eun-Soo Lee0Eun-Young Lee1Jisoo Yoon2Ahreum Hong3Sang-Jip Nam4Jaeyoung Ko5Amorepacific Corporation R&D Center, Yongin 17074, KoreaDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, KoreaDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, KoreaGraduate School of Industrial Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, KoreaDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, KoreaAmorepacific Corporation R&D Center, Yongin 17074, KoreaMany bioactive materials have been isolated from marine microorganisms, including alkaloids, peptides, lipids, mycosporine-like amino acids, glycosides, and isoprenoids. Some of these compounds have great potential in the cosmetic industry due to their photo-protective, anti-aging, and anti-oxidant activities. In this study, sarmentosamide (<b>1</b>) was isolated from marine-derived <i>Streptomyces</i> sp. APmarine042, after which its capacity to decrease skin aging was examined in-vitro. Sarmentosamide (<b>1</b>) was found to significantly reduce UVB-induced matrix metalloproteinase-1 (MMP-1) expression in normal human dermal fibroblasts (NHDFs) by inhibiting the extracellular signal-regulated kinase (ERK) and the c-Jun N-terminal kinase (JNK) phosphorylation, which are regulatory pathways upstream of MMP-1 transcription. Additionally, we confirmed that sarmentosamide (<b>1</b>) decreased tumor necrosis factor-alpha (TNF-α), induced MMP-1 secretion in NHDFs, and exhibited free-radical scavenging activity, as demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Therefore, our study suggests that sarmentosamide (<b>1</b>) could be a promising anti-aging agent that acts via the downregulation of MMP-1 expression.https://www.mdpi.com/1660-3397/18/9/463sarmentosamide<i>Streptomyces</i> sp. APmarine042anti-agingMMP-1UVBTNF-α |
| spellingShingle | Eun-Soo Lee Eun-Young Lee Jisoo Yoon Ahreum Hong Sang-Jip Nam Jaeyoung Ko Sarmentosamide, an Anti-Aging Compound from a Marine-Derived <i>Streptomyces</i> sp. APmarine042 Marine Drugs sarmentosamide <i>Streptomyces</i> sp. APmarine042 anti-aging MMP-1 UVB TNF-α |
| title | Sarmentosamide, an Anti-Aging Compound from a Marine-Derived <i>Streptomyces</i> sp. APmarine042 |
| title_full | Sarmentosamide, an Anti-Aging Compound from a Marine-Derived <i>Streptomyces</i> sp. APmarine042 |
| title_fullStr | Sarmentosamide, an Anti-Aging Compound from a Marine-Derived <i>Streptomyces</i> sp. APmarine042 |
| title_full_unstemmed | Sarmentosamide, an Anti-Aging Compound from a Marine-Derived <i>Streptomyces</i> sp. APmarine042 |
| title_short | Sarmentosamide, an Anti-Aging Compound from a Marine-Derived <i>Streptomyces</i> sp. APmarine042 |
| title_sort | sarmentosamide an anti aging compound from a marine derived i streptomyces i sp apmarine042 |
| topic | sarmentosamide <i>Streptomyces</i> sp. APmarine042 anti-aging MMP-1 UVB TNF-α |
| url | https://www.mdpi.com/1660-3397/18/9/463 |
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