Effects of tDCS on Sound Duration in Patients with Apraxia of Speech in Primary Progressive Aphasia
Transcranial direct current stimulation (tDCS) over the left inferior frontal gyrus (IFG) was found to improve oral and written naming in post-stroke and primary progressive aphasia (PPA), speech fluency in stuttering, a developmental speech-motor disorder, and apraxia of speech (AOS) symptoms in po...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/3/335 |
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| author | Charalambos Themistocleous Kimberly Webster Kyrana Tsapkini |
| author_facet | Charalambos Themistocleous Kimberly Webster Kyrana Tsapkini |
| author_sort | Charalambos Themistocleous |
| collection | DOAJ |
| description | Transcranial direct current stimulation (tDCS) over the left inferior frontal gyrus (IFG) was found to improve oral and written naming in post-stroke and primary progressive aphasia (PPA), speech fluency in stuttering, a developmental speech-motor disorder, and apraxia of speech (AOS) symptoms in post-stroke aphasia. This paper addressed the question of whether tDCS over the left IFG coupled with speech therapy may improve sound duration in patients with apraxia of speech (AOS) symptoms in non-fluent PPA (nfvPPA/AOS) more than sham. Eight patients with non-fluent PPA/AOS received either active or sham tDCS, along with speech therapy for 15 sessions. Speech therapy involved repeating words of increasing syllable-length. Evaluations took place before, immediately after, and two months post-intervention. Words were segmented into vowels and consonants and the duration of each vowel and consonant was measured. Segmental duration was significantly shorter after tDCS compared to sham and tDCS gains generalized to untrained words. The effects of tDCS sustained over two months post-treatment in trained and untrained sounds. Taken together, these results demonstrate that tDCS over the left IFG may facilitate speech production by reducing segmental duration. The results provide preliminary evidence that tDCS may maximize efficacy of speech therapy in patients with nfvPPA/AOS. |
| first_indexed | 2024-03-09T05:08:57Z |
| format | Article |
| id | doaj.art-4b3c9f4ab2a04adfa282909368991b6d |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T05:08:57Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-4b3c9f4ab2a04adfa282909368991b6d2023-12-03T12:51:02ZengMDPI AGBrain Sciences2076-34252021-03-0111333510.3390/brainsci11030335Effects of tDCS on Sound Duration in Patients with Apraxia of Speech in Primary Progressive AphasiaCharalambos Themistocleous0Kimberly Webster1Kyrana Tsapkini2Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21210, USADepartment of Otolaryngology, Johns Hopkins Medicine, Baltimore, MD 21210, USADepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21210, USATranscranial direct current stimulation (tDCS) over the left inferior frontal gyrus (IFG) was found to improve oral and written naming in post-stroke and primary progressive aphasia (PPA), speech fluency in stuttering, a developmental speech-motor disorder, and apraxia of speech (AOS) symptoms in post-stroke aphasia. This paper addressed the question of whether tDCS over the left IFG coupled with speech therapy may improve sound duration in patients with apraxia of speech (AOS) symptoms in non-fluent PPA (nfvPPA/AOS) more than sham. Eight patients with non-fluent PPA/AOS received either active or sham tDCS, along with speech therapy for 15 sessions. Speech therapy involved repeating words of increasing syllable-length. Evaluations took place before, immediately after, and two months post-intervention. Words were segmented into vowels and consonants and the duration of each vowel and consonant was measured. Segmental duration was significantly shorter after tDCS compared to sham and tDCS gains generalized to untrained words. The effects of tDCS sustained over two months post-treatment in trained and untrained sounds. Taken together, these results demonstrate that tDCS over the left IFG may facilitate speech production by reducing segmental duration. The results provide preliminary evidence that tDCS may maximize efficacy of speech therapy in patients with nfvPPA/AOS.https://www.mdpi.com/2076-3425/11/3/335apraxia of speech (AOS)transcranial direct current stimulation (tDCS)primary progressive aphasia (PPA)inferior frontal gyrus (IFG)sound durationbrain stimulation |
| spellingShingle | Charalambos Themistocleous Kimberly Webster Kyrana Tsapkini Effects of tDCS on Sound Duration in Patients with Apraxia of Speech in Primary Progressive Aphasia Brain Sciences apraxia of speech (AOS) transcranial direct current stimulation (tDCS) primary progressive aphasia (PPA) inferior frontal gyrus (IFG) sound duration brain stimulation |
| title | Effects of tDCS on Sound Duration in Patients with Apraxia of Speech in Primary Progressive Aphasia |
| title_full | Effects of tDCS on Sound Duration in Patients with Apraxia of Speech in Primary Progressive Aphasia |
| title_fullStr | Effects of tDCS on Sound Duration in Patients with Apraxia of Speech in Primary Progressive Aphasia |
| title_full_unstemmed | Effects of tDCS on Sound Duration in Patients with Apraxia of Speech in Primary Progressive Aphasia |
| title_short | Effects of tDCS on Sound Duration in Patients with Apraxia of Speech in Primary Progressive Aphasia |
| title_sort | effects of tdcs on sound duration in patients with apraxia of speech in primary progressive aphasia |
| topic | apraxia of speech (AOS) transcranial direct current stimulation (tDCS) primary progressive aphasia (PPA) inferior frontal gyrus (IFG) sound duration brain stimulation |
| url | https://www.mdpi.com/2076-3425/11/3/335 |
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