The calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease

The calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease

Expression of the Down syndrome critical region 1 (DSCR1) protein, an inhibitor of the Ca2+-dependent phosphatase calcineurin, is elevated in the brains of individuals with Down syndrome (DS) or Alzheimer's disease (AD). Although increased levels of DSCR1 were often observed to be deleterious t...

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Bibliographic Details
Main Authors: Soojin Lee, Se Min Bang, Yoon Ki Hong, Jang Ho Lee, Haemin Jeong, Seung Hwan Park, Quan Feng Liu, Im-Soon Lee, Kyoung Sang Cho
Format: Article
Language:English
Published: The Company of Biologists 2016-03-01
Series:Disease Models & Mechanisms
Subjects:
Alzheimer's disease
Amyloid-β42
Drosophila
DSCR1 (RCAN1)
sarah (nebula)
Online Access:http://dmm.biologists.org/content/9/3/295

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