Light‐to‐Heat Photothermal Dynamic Properties of Polypyrrole‐Based Coating for Regenerative Therapy and Lab‐on‐a‐Chip Applications
Abstract Targeted delivery and release of biomolecules, e.g., bone morphogenetic protein (BMP‐2), are gaining high interest due to the application for tissue engineering, diagnostics, surface‐enhanced therapy and lab‐on‐a‐chip. Here, a new hybrid temperature‐responsive system consisting of polypyrro...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2020-11-01
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| Series: | Advanced Materials Interfaces |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/admi.202000980 |
| _version_ | 1797730872935317504 |
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| author | Sviatlana Ulasevich Nikolay V. Ryzhkov Daria V. Andreeva Dilek Sura Özden Erhan Piskin Ekaterina V. Skorb |
| author_facet | Sviatlana Ulasevich Nikolay V. Ryzhkov Daria V. Andreeva Dilek Sura Özden Erhan Piskin Ekaterina V. Skorb |
| author_sort | Sviatlana Ulasevich |
| collection | DOAJ |
| description | Abstract Targeted delivery and release of biomolecules, e.g., bone morphogenetic protein (BMP‐2), are gaining high interest due to the application for tissue engineering, diagnostics, surface‐enhanced therapy and lab‐on‐a‐chip. Here, a new hybrid temperature‐responsive system consisting of polypyrrole (PPy) layer, mesoporous titania surface (TMS), and BMP‐2 is proposed. The PPy layer has the light‐to‐heat photothermal property. Dynamic behavior of the PPy layer in response to light can regulate release of BMP‐2. The PPy‐based coatings on TMS have shown to be efficient for storage of BMP‐2 and can be tuned to release BMP‐2 under irradiation. Moreover, the possibility of local delivery and generation of a gradual release of BMP‐2 for regulated cell growth is shown. Furthermore, the fabricated surfaces possess excellent biocompatibility and low cytotoxicity for MC3T3‐E1 cells. It is shown that the released BMP‐2 can effectively promote osteogenic differentiation of MC3T3‐E1 cells. Thus, the TMS/PPy–BMP‐2 is suggested to prolong targeted release of the BMP‐2 for more than 25 days which stimulates osteoblasts’ proliferation. The new stimuli‐responsive hybrid system is promising for targeted, localized, sustained drug release and application in bone tissue engineering. |
| first_indexed | 2024-03-12T11:50:30Z |
| format | Article |
| id | doaj.art-4b3e54d79411427b904adf147bb0be28 |
| institution | Directory Open Access Journal |
| issn | 2196-7350 |
| language | English |
| last_indexed | 2024-03-12T11:50:30Z |
| publishDate | 2020-11-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Materials Interfaces |
| spelling | doaj.art-4b3e54d79411427b904adf147bb0be282023-08-31T08:56:02ZengWiley-VCHAdvanced Materials Interfaces2196-73502020-11-01721n/an/a10.1002/admi.202000980Light‐to‐Heat Photothermal Dynamic Properties of Polypyrrole‐Based Coating for Regenerative Therapy and Lab‐on‐a‐Chip ApplicationsSviatlana Ulasevich0Nikolay V. Ryzhkov1Daria V. Andreeva2Dilek Sura Özden3Erhan Piskin4Ekaterina V. Skorb5Infochemistry Scientific Center of ITMO University ITMO University Lomonosova str. 9 St. Petersburg 191002 RussiaInfochemistry Scientific Center of ITMO University ITMO University Lomonosova str. 9 St. Petersburg 191002 RussiaDepartment of Materials Science and Engineering National University of Singapore Singapore 117575 SingaporeChemical Engineering Department and Bioengineering Division Center for Bioengineering and Biyomedtek/Nanobiyomedtek Hacettepe University Beytepe Ankara 06800 TurkeyNanoBMT Nanobiyomedtek Biyomedikal and Biyoteknoloji San.Tic., Ltd.Sti. Bilkent University 56 Cyberpark, Bilkent Ankara 06800 TurkeyInfochemistry Scientific Center of ITMO University ITMO University Lomonosova str. 9 St. Petersburg 191002 RussiaAbstract Targeted delivery and release of biomolecules, e.g., bone morphogenetic protein (BMP‐2), are gaining high interest due to the application for tissue engineering, diagnostics, surface‐enhanced therapy and lab‐on‐a‐chip. Here, a new hybrid temperature‐responsive system consisting of polypyrrole (PPy) layer, mesoporous titania surface (TMS), and BMP‐2 is proposed. The PPy layer has the light‐to‐heat photothermal property. Dynamic behavior of the PPy layer in response to light can regulate release of BMP‐2. The PPy‐based coatings on TMS have shown to be efficient for storage of BMP‐2 and can be tuned to release BMP‐2 under irradiation. Moreover, the possibility of local delivery and generation of a gradual release of BMP‐2 for regulated cell growth is shown. Furthermore, the fabricated surfaces possess excellent biocompatibility and low cytotoxicity for MC3T3‐E1 cells. It is shown that the released BMP‐2 can effectively promote osteogenic differentiation of MC3T3‐E1 cells. Thus, the TMS/PPy–BMP‐2 is suggested to prolong targeted release of the BMP‐2 for more than 25 days which stimulates osteoblasts’ proliferation. The new stimuli‐responsive hybrid system is promising for targeted, localized, sustained drug release and application in bone tissue engineering.https://doi.org/10.1002/admi.202000980mesoporous titaniapolyelectrolytespolymer coatingpolypyrroleultrasonic treatment |
| spellingShingle | Sviatlana Ulasevich Nikolay V. Ryzhkov Daria V. Andreeva Dilek Sura Özden Erhan Piskin Ekaterina V. Skorb Light‐to‐Heat Photothermal Dynamic Properties of Polypyrrole‐Based Coating for Regenerative Therapy and Lab‐on‐a‐Chip Applications Advanced Materials Interfaces mesoporous titania polyelectrolytes polymer coating polypyrrole ultrasonic treatment |
| title | Light‐to‐Heat Photothermal Dynamic Properties of Polypyrrole‐Based Coating for Regenerative Therapy and Lab‐on‐a‐Chip Applications |
| title_full | Light‐to‐Heat Photothermal Dynamic Properties of Polypyrrole‐Based Coating for Regenerative Therapy and Lab‐on‐a‐Chip Applications |
| title_fullStr | Light‐to‐Heat Photothermal Dynamic Properties of Polypyrrole‐Based Coating for Regenerative Therapy and Lab‐on‐a‐Chip Applications |
| title_full_unstemmed | Light‐to‐Heat Photothermal Dynamic Properties of Polypyrrole‐Based Coating for Regenerative Therapy and Lab‐on‐a‐Chip Applications |
| title_short | Light‐to‐Heat Photothermal Dynamic Properties of Polypyrrole‐Based Coating for Regenerative Therapy and Lab‐on‐a‐Chip Applications |
| title_sort | light to heat photothermal dynamic properties of polypyrrole based coating for regenerative therapy and lab on a chip applications |
| topic | mesoporous titania polyelectrolytes polymer coating polypyrrole ultrasonic treatment |
| url | https://doi.org/10.1002/admi.202000980 |
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