Relationship between Serum Ferritin and Outcomes in β-Thalassemia: A Systematic Literature Review
Among the difficulties of living with β-thalassemia, patients frequently require blood transfusions and experience iron overload. As serum ferritin (SF) provides an indication of potential iron overload, we conducted a systematic literature review (SLR) to assess whether SF levels are associated wit...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/15/4448 |
| _version_ | 1797432830103388160 |
|---|---|
| author | Farrukh Shah Krystal Huey Sohan Deshpande Monica Turner Madhura Chitnis Emma Schiller Aylin Yucel Luciana Moro Bueno Esther Natalie Oliva |
| author_facet | Farrukh Shah Krystal Huey Sohan Deshpande Monica Turner Madhura Chitnis Emma Schiller Aylin Yucel Luciana Moro Bueno Esther Natalie Oliva |
| author_sort | Farrukh Shah |
| collection | DOAJ |
| description | Among the difficulties of living with β-thalassemia, patients frequently require blood transfusions and experience iron overload. As serum ferritin (SF) provides an indication of potential iron overload, we conducted a systematic literature review (SLR) to assess whether SF levels are associated with clinical and economic burden and patient-reported outcomes (PROs). The SLR was conducted on 23 April 2020 and followed by analysis of the literature. Dual-screening was performed at the title, abstract, and full-text levels using predefined inclusion and exclusion criteria. Ten studies identified by the SLR were eligible for inclusion in the analysis. Seven studies were conducted in Europe, and most were prospective or retrospective in design. The patient populations had a median age of 20.7–42.6 years, with a percentage of men of 38–80%. Sparse data were found on the correlation between SF levels and mortality, and hepatic, skeletal, and cardiac complications; however, in general, higher SF levels were associated with worsened outcomes. The bulk of the evidence reported on the significant association between higher SF levels and endocrine dysfunction in its many presentations, including a 14-fold increase in the risk of diabetes for patients with persistently elevated SF levels. No studies reporting data on PROs or economic burden were identified by the SLR. SF levels provide another option for prognostic assessment to predict a range of clinical outcomes in patients with β-thalassemia. |
| first_indexed | 2024-03-09T10:07:18Z |
| format | Article |
| id | doaj.art-4b3e71512b9d473c86075c2b4e1dacef |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T10:07:18Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-4b3e71512b9d473c86075c2b4e1dacef2023-12-01T22:59:39ZengMDPI AGJournal of Clinical Medicine2077-03832022-07-011115444810.3390/jcm11154448Relationship between Serum Ferritin and Outcomes in β-Thalassemia: A Systematic Literature ReviewFarrukh Shah0Krystal Huey1Sohan Deshpande2Monica Turner3Madhura Chitnis4Emma Schiller5Aylin Yucel6Luciana Moro Bueno7Esther Natalie Oliva8Department of Haematology, Whittington Health NHS Foundation Trust, London N19 5NF, UKBristol Myers Squibb, Princeton, NJ 08648, USAEvidera, London W6 8BJ, UKEvidera, Waltham, MA 02451, USAEvidera, Waltham, MA 02451, USAEvidera, Waltham, MA 02451, USABristol Myers Squibb, Princeton, NJ 08648, USABristol Myers Squibb, Princeton, NJ 08648, USAHematology Unit, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, 89124 Reggio Calabria, ItalyAmong the difficulties of living with β-thalassemia, patients frequently require blood transfusions and experience iron overload. As serum ferritin (SF) provides an indication of potential iron overload, we conducted a systematic literature review (SLR) to assess whether SF levels are associated with clinical and economic burden and patient-reported outcomes (PROs). The SLR was conducted on 23 April 2020 and followed by analysis of the literature. Dual-screening was performed at the title, abstract, and full-text levels using predefined inclusion and exclusion criteria. Ten studies identified by the SLR were eligible for inclusion in the analysis. Seven studies were conducted in Europe, and most were prospective or retrospective in design. The patient populations had a median age of 20.7–42.6 years, with a percentage of men of 38–80%. Sparse data were found on the correlation between SF levels and mortality, and hepatic, skeletal, and cardiac complications; however, in general, higher SF levels were associated with worsened outcomes. The bulk of the evidence reported on the significant association between higher SF levels and endocrine dysfunction in its many presentations, including a 14-fold increase in the risk of diabetes for patients with persistently elevated SF levels. No studies reporting data on PROs or economic burden were identified by the SLR. SF levels provide another option for prognostic assessment to predict a range of clinical outcomes in patients with β-thalassemia.https://www.mdpi.com/2077-0383/11/15/4448β-thalassemiairon overloadserum ferritinsystematic literature review |
| spellingShingle | Farrukh Shah Krystal Huey Sohan Deshpande Monica Turner Madhura Chitnis Emma Schiller Aylin Yucel Luciana Moro Bueno Esther Natalie Oliva Relationship between Serum Ferritin and Outcomes in β-Thalassemia: A Systematic Literature Review Journal of Clinical Medicine β-thalassemia iron overload serum ferritin systematic literature review |
| title | Relationship between Serum Ferritin and Outcomes in β-Thalassemia: A Systematic Literature Review |
| title_full | Relationship between Serum Ferritin and Outcomes in β-Thalassemia: A Systematic Literature Review |
| title_fullStr | Relationship between Serum Ferritin and Outcomes in β-Thalassemia: A Systematic Literature Review |
| title_full_unstemmed | Relationship between Serum Ferritin and Outcomes in β-Thalassemia: A Systematic Literature Review |
| title_short | Relationship between Serum Ferritin and Outcomes in β-Thalassemia: A Systematic Literature Review |
| title_sort | relationship between serum ferritin and outcomes in β thalassemia a systematic literature review |
| topic | β-thalassemia iron overload serum ferritin systematic literature review |
| url | https://www.mdpi.com/2077-0383/11/15/4448 |
| work_keys_str_mv | AT farrukhshah relationshipbetweenserumferritinandoutcomesinbthalassemiaasystematicliteraturereview AT krystalhuey relationshipbetweenserumferritinandoutcomesinbthalassemiaasystematicliteraturereview AT sohandeshpande relationshipbetweenserumferritinandoutcomesinbthalassemiaasystematicliteraturereview AT monicaturner relationshipbetweenserumferritinandoutcomesinbthalassemiaasystematicliteraturereview AT madhurachitnis relationshipbetweenserumferritinandoutcomesinbthalassemiaasystematicliteraturereview AT emmaschiller relationshipbetweenserumferritinandoutcomesinbthalassemiaasystematicliteraturereview AT aylinyucel relationshipbetweenserumferritinandoutcomesinbthalassemiaasystematicliteraturereview AT lucianamorobueno relationshipbetweenserumferritinandoutcomesinbthalassemiaasystematicliteraturereview AT esthernatalieoliva relationshipbetweenserumferritinandoutcomesinbthalassemiaasystematicliteraturereview |