Transitional Cell Carcinoma of the Bladder Manifestating as Malignant Lymphoma with Generalized Lymphadenopathy
Bladder cancer usually spreads via the lymphatic and hematogenous routes, the most common sites of metastases of urinary bladder cancers being the regional lymph nodes, liver, lung, bone, peritoneum, pleura, kidney, adrenal gland and intestines. Generalized lymph node metastasis of transitional cell...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2010-04-01
|
| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/312424 |
| _version_ | 1811284293547196416 |
|---|---|
| author | Venkat Pavan Kancharla Frederick A. Gulmi Aref Agheli Michael Degen Arash Gohari Ming Jiang J.C. Wang |
| author_facet | Venkat Pavan Kancharla Frederick A. Gulmi Aref Agheli Michael Degen Arash Gohari Ming Jiang J.C. Wang |
| author_sort | Venkat Pavan Kancharla |
| collection | DOAJ |
| description | Bladder cancer usually spreads via the lymphatic and hematogenous routes, the most common sites of metastases of urinary bladder cancers being the regional lymph nodes, liver, lung, bone, peritoneum, pleura, kidney, adrenal gland and intestines. Generalized lymph node metastasis of transitional cell cancer of the bladder is extremely rare. According to our literature search, there has been no case report of transitional cell cancer of the bladder that manifests as an extensive large lymph node metastasis involving the intraparotid, supraclavicular thoracic inlet, axillary and regional abdominal and pelvic lymph nodes without bone or visceral organs involved. Such a presentation could be mistaken as malignant lymphoma and the importance of a biopsy of the lymph nodes is emphasized. The clinical course of rapid progression of the disease and the presence of wild-type p53 with rapid response to chemotherapy and a short remission may represent a unique case, which is discussed here. |
| first_indexed | 2024-04-13T02:27:32Z |
| format | Article |
| id | doaj.art-4b3e9a9527c642a185151250f368e9f5 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-13T02:27:32Z |
| publishDate | 2010-04-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-4b3e9a9527c642a185151250f368e9f52022-12-22T03:06:44ZengKarger PublishersCase Reports in Oncology1662-65752010-04-013212513010.1159/000312424312424Transitional Cell Carcinoma of the Bladder Manifestating as Malignant Lymphoma with Generalized LymphadenopathyVenkat Pavan KancharlaFrederick A. GulmiAref AgheliMichael DegenArash GohariMing JiangJ.C. WangBladder cancer usually spreads via the lymphatic and hematogenous routes, the most common sites of metastases of urinary bladder cancers being the regional lymph nodes, liver, lung, bone, peritoneum, pleura, kidney, adrenal gland and intestines. Generalized lymph node metastasis of transitional cell cancer of the bladder is extremely rare. According to our literature search, there has been no case report of transitional cell cancer of the bladder that manifests as an extensive large lymph node metastasis involving the intraparotid, supraclavicular thoracic inlet, axillary and regional abdominal and pelvic lymph nodes without bone or visceral organs involved. Such a presentation could be mistaken as malignant lymphoma and the importance of a biopsy of the lymph nodes is emphasized. The clinical course of rapid progression of the disease and the presence of wild-type p53 with rapid response to chemotherapy and a short remission may represent a unique case, which is discussed here.http://www.karger.com/Article/FullText/312424Transitional cell bladder cancerMalignant lymphomaGeneralized lymphadenopathyMetastasis |
| spellingShingle | Venkat Pavan Kancharla Frederick A. Gulmi Aref Agheli Michael Degen Arash Gohari Ming Jiang J.C. Wang Transitional Cell Carcinoma of the Bladder Manifestating as Malignant Lymphoma with Generalized Lymphadenopathy Case Reports in Oncology Transitional cell bladder cancer Malignant lymphoma Generalized lymphadenopathy Metastasis |
| title | Transitional Cell Carcinoma of the Bladder Manifestating as Malignant Lymphoma with Generalized Lymphadenopathy |
| title_full | Transitional Cell Carcinoma of the Bladder Manifestating as Malignant Lymphoma with Generalized Lymphadenopathy |
| title_fullStr | Transitional Cell Carcinoma of the Bladder Manifestating as Malignant Lymphoma with Generalized Lymphadenopathy |
| title_full_unstemmed | Transitional Cell Carcinoma of the Bladder Manifestating as Malignant Lymphoma with Generalized Lymphadenopathy |
| title_short | Transitional Cell Carcinoma of the Bladder Manifestating as Malignant Lymphoma with Generalized Lymphadenopathy |
| title_sort | transitional cell carcinoma of the bladder manifestating as malignant lymphoma with generalized lymphadenopathy |
| topic | Transitional cell bladder cancer Malignant lymphoma Generalized lymphadenopathy Metastasis |
| url | http://www.karger.com/Article/FullText/312424 |
| work_keys_str_mv | AT venkatpavankancharla transitionalcellcarcinomaofthebladdermanifestatingasmalignantlymphomawithgeneralizedlymphadenopathy AT frederickagulmi transitionalcellcarcinomaofthebladdermanifestatingasmalignantlymphomawithgeneralizedlymphadenopathy AT arefagheli transitionalcellcarcinomaofthebladdermanifestatingasmalignantlymphomawithgeneralizedlymphadenopathy AT michaeldegen transitionalcellcarcinomaofthebladdermanifestatingasmalignantlymphomawithgeneralizedlymphadenopathy AT arashgohari transitionalcellcarcinomaofthebladdermanifestatingasmalignantlymphomawithgeneralizedlymphadenopathy AT mingjiang transitionalcellcarcinomaofthebladdermanifestatingasmalignantlymphomawithgeneralizedlymphadenopathy AT jcwang transitionalcellcarcinomaofthebladdermanifestatingasmalignantlymphomawithgeneralizedlymphadenopathy |