Maternal blood inflammatory marker levels increased in fetuses with ventriculomegaly
BackgroundFetal ventriculomegaly (VM) is one of the most common abnormalities of the central nervous system (CNS), which can be significantly identified by brain anomalies prenatally by magnetic resonance imaging (MRI). Aberrant white blood cells (WBCs) levels indicate that the maternal is suffering...
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2022.998206/full |
| _version_ | 1811314528300826624 |
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| author | Qiang Li Xin-Wei Ju Jing Xu Jiuhong Jiang Chang Lu Chang Lu Xing-Da Ju Xing-Da Ju |
| author_facet | Qiang Li Xin-Wei Ju Jing Xu Jiuhong Jiang Chang Lu Chang Lu Xing-Da Ju Xing-Da Ju |
| author_sort | Qiang Li |
| collection | DOAJ |
| description | BackgroundFetal ventriculomegaly (VM) is one of the most common abnormalities of the central nervous system (CNS), which can be significantly identified by brain anomalies prenatally by magnetic resonance imaging (MRI). Aberrant white blood cells (WBCs) levels indicate that the maternal is suffering from the infection. Previous studies have confirmed that prenatal infection can affect fetal brain structure, but there is no research revealed the association between maternal blood parameters with fetal VM until now.MethodsWe measured the width of the lateral ventricle of 142 fetuses, which were divided into the fetal VM group (n = 70) and the normal lateral ventricle group (n = 72). We compared maternal blood cell levels between the two groups and investigate potential biomarkers of fetal VM.ResultHigh levels of maternal WBC and neutrophil (NE#) levels were observed in fetuses with VM (p < 0.001), while lymphocyte percentage, monocytes (MO#), neutrophil/lymphocyte ratio (NLR), and platelet were also increased in the fetal VM group (p = 0.033, 0.027, 0.034, and 0.025, respectively). receiver–operator curve (ROC) analysis suggested that WBC and NE# counts might be useful to distinguish fetuses with enlarged lateral ventricles (AUC = 0.688, 0.678, respectively).ConclusionThe current study emphasizes the importance of maternal infection for fetal brain growth, which could provide important information for prenatal diagnosis of CNS anomalies. Future research needs longitudinal analysis and exploration of the influence of maternal blood inflammatory marker levels on fetal brain development. |
| first_indexed | 2024-04-13T11:13:13Z |
| format | Article |
| id | doaj.art-4b3ea251bc5e495c9c13ffbc8717de9e |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-13T11:13:13Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-4b3ea251bc5e495c9c13ffbc8717de9e2022-12-22T02:49:03ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-12-011610.3389/fnhum.2022.998206998206Maternal blood inflammatory marker levels increased in fetuses with ventriculomegalyQiang Li0Xin-Wei Ju1Jing Xu2Jiuhong Jiang3Chang Lu4Chang Lu5Xing-Da Ju6Xing-Da Ju7School of Psychology, Northeast Normal University, Changchun, ChinaDepartment of Radiology, The First Hospital of Jilin University, Changchun, ChinaSchool of Life Sciences, Northeast Normal University, Changchun, ChinaSchool of Information Science and Technology, Northeast Normal University, Changchun, ChinaSchool of Psychology, Northeast Normal University, Changchun, ChinaJilin Provincial Key Laboratory of Cognitive Neuroscience and Brain Development, Changchun, ChinaSchool of Psychology, Northeast Normal University, Changchun, ChinaAutism Centre of Excellence, Northeast Normal University, Changchun, ChinaBackgroundFetal ventriculomegaly (VM) is one of the most common abnormalities of the central nervous system (CNS), which can be significantly identified by brain anomalies prenatally by magnetic resonance imaging (MRI). Aberrant white blood cells (WBCs) levels indicate that the maternal is suffering from the infection. Previous studies have confirmed that prenatal infection can affect fetal brain structure, but there is no research revealed the association between maternal blood parameters with fetal VM until now.MethodsWe measured the width of the lateral ventricle of 142 fetuses, which were divided into the fetal VM group (n = 70) and the normal lateral ventricle group (n = 72). We compared maternal blood cell levels between the two groups and investigate potential biomarkers of fetal VM.ResultHigh levels of maternal WBC and neutrophil (NE#) levels were observed in fetuses with VM (p < 0.001), while lymphocyte percentage, monocytes (MO#), neutrophil/lymphocyte ratio (NLR), and platelet were also increased in the fetal VM group (p = 0.033, 0.027, 0.034, and 0.025, respectively). receiver–operator curve (ROC) analysis suggested that WBC and NE# counts might be useful to distinguish fetuses with enlarged lateral ventricles (AUC = 0.688, 0.678, respectively).ConclusionThe current study emphasizes the importance of maternal infection for fetal brain growth, which could provide important information for prenatal diagnosis of CNS anomalies. Future research needs longitudinal analysis and exploration of the influence of maternal blood inflammatory marker levels on fetal brain development.https://www.frontiersin.org/articles/10.3389/fnhum.2022.998206/fullfetal ventriculomegalyprenatal infectioninflammatory markersneurodevelopmentbiomarkers brain alterations |
| spellingShingle | Qiang Li Xin-Wei Ju Jing Xu Jiuhong Jiang Chang Lu Chang Lu Xing-Da Ju Xing-Da Ju Maternal blood inflammatory marker levels increased in fetuses with ventriculomegaly Frontiers in Human Neuroscience fetal ventriculomegaly prenatal infection inflammatory markers neurodevelopment biomarkers brain alterations |
| title | Maternal blood inflammatory marker levels increased in fetuses with ventriculomegaly |
| title_full | Maternal blood inflammatory marker levels increased in fetuses with ventriculomegaly |
| title_fullStr | Maternal blood inflammatory marker levels increased in fetuses with ventriculomegaly |
| title_full_unstemmed | Maternal blood inflammatory marker levels increased in fetuses with ventriculomegaly |
| title_short | Maternal blood inflammatory marker levels increased in fetuses with ventriculomegaly |
| title_sort | maternal blood inflammatory marker levels increased in fetuses with ventriculomegaly |
| topic | fetal ventriculomegaly prenatal infection inflammatory markers neurodevelopment biomarkers brain alterations |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2022.998206/full |
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