Skin Microbiome Modulates the Effect of Ultraviolet Radiation on Cellular Response and Immune Function
Summary: The skin is colonized by a diverse microbiome intricately involved in various molecular and cellular processes within the skin and beyond. UV radiation is known to induce profound changes in the skin and modulate the immune response. However, the role of the microbiome in UV-induced immune...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-05-01
|
| Series: | iScience |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004219301233 |
| _version_ | 1819147683896492032 |
|---|---|
| author | VijayKumar Patra Karin Wagner Velmurugesan Arulampalam Peter Wolf |
| author_facet | VijayKumar Patra Karin Wagner Velmurugesan Arulampalam Peter Wolf |
| author_sort | VijayKumar Patra |
| collection | DOAJ |
| description | Summary: The skin is colonized by a diverse microbiome intricately involved in various molecular and cellular processes within the skin and beyond. UV radiation is known to induce profound changes in the skin and modulate the immune response. However, the role of the microbiome in UV-induced immune suppression has been overlooked. By employing the standard model of contact hypersensitivity (using germ-free mice) we found diminished UV-induced systemic immune suppression in the presence of microbiome. Upon UV exposure, we found enhanced epidermal hyperplasia and neutrophilic infiltration in the presence and enhanced numbers of mast cells and monocyte or macrophages in the absence of microbiome. Transcriptome analysis revealed a predominant expression of cytokine genes related to pro-inflammatory milieu in the presence versus immunosuppressive milieu (with increased interleukin-10) in the absence of microbiome. Collectively, microbiome abrogates the immunosuppressive response to UV by modulating gene expression and cellular microenvironment of the skin. : Dermatology; Radiation Biology; Immune Response; Microbiome Subject Areas: Dermatology, Radiation Biology, Immune Response, Microbiome |
| first_indexed | 2024-12-22T13:33:43Z |
| format | Article |
| id | doaj.art-4b3f9c7b75d541ac92f71daa797f77be |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-22T13:33:43Z |
| publishDate | 2019-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-4b3f9c7b75d541ac92f71daa797f77be2022-12-21T18:24:06ZengElsevieriScience2589-00422019-05-0115211222Skin Microbiome Modulates the Effect of Ultraviolet Radiation on Cellular Response and Immune FunctionVijayKumar Patra0Karin Wagner1Velmurugesan Arulampalam2Peter Wolf3Center for Medical Research, Medical University of Graz, Graz, Austria; Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria; Core Facility for Germfree Research (CFGR), Department of Comparative Medicine and Department of Microbiology, Tumor, and Cell Biology (MTC), Karolinska Institutet, Stockholm, SwedenCenter for Medical Research, Medical University of Graz, Graz, AustriaCore Facility for Germfree Research (CFGR), Department of Comparative Medicine and Department of Microbiology, Tumor, and Cell Biology (MTC), Karolinska Institutet, Stockholm, SwedenResearch Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria; Corresponding authorSummary: The skin is colonized by a diverse microbiome intricately involved in various molecular and cellular processes within the skin and beyond. UV radiation is known to induce profound changes in the skin and modulate the immune response. However, the role of the microbiome in UV-induced immune suppression has been overlooked. By employing the standard model of contact hypersensitivity (using germ-free mice) we found diminished UV-induced systemic immune suppression in the presence of microbiome. Upon UV exposure, we found enhanced epidermal hyperplasia and neutrophilic infiltration in the presence and enhanced numbers of mast cells and monocyte or macrophages in the absence of microbiome. Transcriptome analysis revealed a predominant expression of cytokine genes related to pro-inflammatory milieu in the presence versus immunosuppressive milieu (with increased interleukin-10) in the absence of microbiome. Collectively, microbiome abrogates the immunosuppressive response to UV by modulating gene expression and cellular microenvironment of the skin. : Dermatology; Radiation Biology; Immune Response; Microbiome Subject Areas: Dermatology, Radiation Biology, Immune Response, Microbiomehttp://www.sciencedirect.com/science/article/pii/S2589004219301233 |
| spellingShingle | VijayKumar Patra Karin Wagner Velmurugesan Arulampalam Peter Wolf Skin Microbiome Modulates the Effect of Ultraviolet Radiation on Cellular Response and Immune Function iScience |
| title | Skin Microbiome Modulates the Effect of Ultraviolet Radiation on Cellular Response and Immune Function |
| title_full | Skin Microbiome Modulates the Effect of Ultraviolet Radiation on Cellular Response and Immune Function |
| title_fullStr | Skin Microbiome Modulates the Effect of Ultraviolet Radiation on Cellular Response and Immune Function |
| title_full_unstemmed | Skin Microbiome Modulates the Effect of Ultraviolet Radiation on Cellular Response and Immune Function |
| title_short | Skin Microbiome Modulates the Effect of Ultraviolet Radiation on Cellular Response and Immune Function |
| title_sort | skin microbiome modulates the effect of ultraviolet radiation on cellular response and immune function |
| url | http://www.sciencedirect.com/science/article/pii/S2589004219301233 |
| work_keys_str_mv | AT vijaykumarpatra skinmicrobiomemodulatestheeffectofultravioletradiationoncellularresponseandimmunefunction AT karinwagner skinmicrobiomemodulatestheeffectofultravioletradiationoncellularresponseandimmunefunction AT velmurugesanarulampalam skinmicrobiomemodulatestheeffectofultravioletradiationoncellularresponseandimmunefunction AT peterwolf skinmicrobiomemodulatestheeffectofultravioletradiationoncellularresponseandimmunefunction |