Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythms
Abstract Temperature compensation and robustness to biological noise are two key characteristics of the circadian clock. These features allow the circadian pacemaker to maintain a steady oscillation in a wide range of environmental conditions. The presence of a time-delayed negative feedback loop in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-02-01
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| Series: | npj Systems Biology and Applications |
| Online Access: | https://doi.org/10.1038/s41540-023-00268-7 |
| _version_ | 1811165837604683776 |
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| author | Suchana Chakravarty Christian I. Hong Attila Csikász-Nagy |
| author_facet | Suchana Chakravarty Christian I. Hong Attila Csikász-Nagy |
| author_sort | Suchana Chakravarty |
| collection | DOAJ |
| description | Abstract Temperature compensation and robustness to biological noise are two key characteristics of the circadian clock. These features allow the circadian pacemaker to maintain a steady oscillation in a wide range of environmental conditions. The presence of a time-delayed negative feedback loop in the regulatory network generates autonomous circadian oscillations in eukaryotic systems. In comparison, the circadian clock of cyanobacteria is controlled by a strong positive feedback loop. Positive feedback loops with substrate depletion can also generate oscillations, inspiring other circadian clock models. What makes a circadian oscillatory network robust to extrinsic noise is unclear. We investigated four basic circadian oscillators with negative, positive, and combinations of positive and negative feedback loops to explore network features necessary for circadian clock resilience. We discovered that the negative feedback loop system performs the best in compensating temperature changes. We also show that a positive feedback loop can reduce extrinsic noise in periods of circadian oscillators, while intrinsic noise is reduced by negative feedback loops. |
| first_indexed | 2024-04-10T15:43:08Z |
| format | Article |
| id | doaj.art-4b4028fef0044130bd52333897e90dd7 |
| institution | Directory Open Access Journal |
| issn | 2056-7189 |
| language | English |
| last_indexed | 2024-04-10T15:43:08Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Systems Biology and Applications |
| spelling | doaj.art-4b4028fef0044130bd52333897e90dd72023-02-12T12:15:33ZengNature Portfolionpj Systems Biology and Applications2056-71892023-02-019111010.1038/s41540-023-00268-7Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythmsSuchana Chakravarty0Christian I. Hong1Attila Csikász-Nagy2Faculty of Information Technology and Bionics, Pázmány Péter Catholic UniversityDepartment of Pharmacology & Systems Physiology, University of CincinnatiFaculty of Information Technology and Bionics, Pázmány Péter Catholic UniversityAbstract Temperature compensation and robustness to biological noise are two key characteristics of the circadian clock. These features allow the circadian pacemaker to maintain a steady oscillation in a wide range of environmental conditions. The presence of a time-delayed negative feedback loop in the regulatory network generates autonomous circadian oscillations in eukaryotic systems. In comparison, the circadian clock of cyanobacteria is controlled by a strong positive feedback loop. Positive feedback loops with substrate depletion can also generate oscillations, inspiring other circadian clock models. What makes a circadian oscillatory network robust to extrinsic noise is unclear. We investigated four basic circadian oscillators with negative, positive, and combinations of positive and negative feedback loops to explore network features necessary for circadian clock resilience. We discovered that the negative feedback loop system performs the best in compensating temperature changes. We also show that a positive feedback loop can reduce extrinsic noise in periods of circadian oscillators, while intrinsic noise is reduced by negative feedback loops.https://doi.org/10.1038/s41540-023-00268-7 |
| spellingShingle | Suchana Chakravarty Christian I. Hong Attila Csikász-Nagy Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythms npj Systems Biology and Applications |
| title | Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythms |
| title_full | Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythms |
| title_fullStr | Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythms |
| title_full_unstemmed | Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythms |
| title_short | Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythms |
| title_sort | systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythms |
| url | https://doi.org/10.1038/s41540-023-00268-7 |
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