L-dopa medication in Parkinson's disease restores activity in the motor cortico-striatal loop but does not modify the cognitive network.
BACKGROUND:The goal of this study was to evaluate the effects of L-Dopa medication in Parkinson's disease (PD) on brain activation during the performance of a set-shifting task. Using fMRI, we have previously studied the patterns of activity observed in patients with PD after overnight removal...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-07-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2702753?pdf=render |
| _version_ | 1818616774633979904 |
|---|---|
| author | Thomas Jubault Laura Monetta Antonio P Strafella Anne-Louise Lafontaine Oury Monchi |
| author_facet | Thomas Jubault Laura Monetta Antonio P Strafella Anne-Louise Lafontaine Oury Monchi |
| author_sort | Thomas Jubault |
| collection | DOAJ |
| description | BACKGROUND:The goal of this study was to evaluate the effects of L-Dopa medication in Parkinson's disease (PD) on brain activation during the performance of a set-shifting task. Using fMRI, we have previously studied the patterns of activity observed in patients with PD after overnight removal of dopaminergic medication compared with control participants during the performance of different stages of the Wisconsin Card Sorting Task (WCST). The results revealed decreased cortical activity in the PD group compared to controls in the conditions that significantly required striatum, while increased cortical activity was observed when striatum was not involved. However, the effect of dopaminergic medication in PD patients on those patterns of activity has not yet been studied. METHODOLOGY/PRINCIPAL FINDINGS:Here, eleven PD patients at early stage of the disease taking L-Dopa medication were recruited and underwent two fMRI sessions while performing the WCST: one session while taking their normal dose of medication and the other following overnight dopaminergic medication withdrawal. We found that L-dopa medication helped restoring a normal pattern of activity when matching and not planning was required, by increasing cortical activity in the premotor cortex. This effect was even stronger in the motor loop, i.e. when the putamen was required for controls, when matching following negative feedback. However, the medication did not change the pattern of activity in conditions relying primarily on a cognitive loop, i.e. when the caudate nucleus was required. CONCLUSIONS/SIGNIFICANCE:These studies provide explanation at the neural level regarding the relatively poor effects of L-Dopa on the cognitive deficits observed in PD. |
| first_indexed | 2024-12-16T16:55:09Z |
| format | Article |
| id | doaj.art-4b42d3c60b4145f9b391a252314e3667 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T16:55:09Z |
| publishDate | 2009-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4b42d3c60b4145f9b391a252314e36672022-12-21T22:23:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-07-0147e615410.1371/journal.pone.0006154L-dopa medication in Parkinson's disease restores activity in the motor cortico-striatal loop but does not modify the cognitive network.Thomas JubaultLaura MonettaAntonio P StrafellaAnne-Louise LafontaineOury MonchiBACKGROUND:The goal of this study was to evaluate the effects of L-Dopa medication in Parkinson's disease (PD) on brain activation during the performance of a set-shifting task. Using fMRI, we have previously studied the patterns of activity observed in patients with PD after overnight removal of dopaminergic medication compared with control participants during the performance of different stages of the Wisconsin Card Sorting Task (WCST). The results revealed decreased cortical activity in the PD group compared to controls in the conditions that significantly required striatum, while increased cortical activity was observed when striatum was not involved. However, the effect of dopaminergic medication in PD patients on those patterns of activity has not yet been studied. METHODOLOGY/PRINCIPAL FINDINGS:Here, eleven PD patients at early stage of the disease taking L-Dopa medication were recruited and underwent two fMRI sessions while performing the WCST: one session while taking their normal dose of medication and the other following overnight dopaminergic medication withdrawal. We found that L-dopa medication helped restoring a normal pattern of activity when matching and not planning was required, by increasing cortical activity in the premotor cortex. This effect was even stronger in the motor loop, i.e. when the putamen was required for controls, when matching following negative feedback. However, the medication did not change the pattern of activity in conditions relying primarily on a cognitive loop, i.e. when the caudate nucleus was required. CONCLUSIONS/SIGNIFICANCE:These studies provide explanation at the neural level regarding the relatively poor effects of L-Dopa on the cognitive deficits observed in PD.http://europepmc.org/articles/PMC2702753?pdf=render |
| spellingShingle | Thomas Jubault Laura Monetta Antonio P Strafella Anne-Louise Lafontaine Oury Monchi L-dopa medication in Parkinson's disease restores activity in the motor cortico-striatal loop but does not modify the cognitive network. PLoS ONE |
| title | L-dopa medication in Parkinson's disease restores activity in the motor cortico-striatal loop but does not modify the cognitive network. |
| title_full | L-dopa medication in Parkinson's disease restores activity in the motor cortico-striatal loop but does not modify the cognitive network. |
| title_fullStr | L-dopa medication in Parkinson's disease restores activity in the motor cortico-striatal loop but does not modify the cognitive network. |
| title_full_unstemmed | L-dopa medication in Parkinson's disease restores activity in the motor cortico-striatal loop but does not modify the cognitive network. |
| title_short | L-dopa medication in Parkinson's disease restores activity in the motor cortico-striatal loop but does not modify the cognitive network. |
| title_sort | l dopa medication in parkinson s disease restores activity in the motor cortico striatal loop but does not modify the cognitive network |
| url | http://europepmc.org/articles/PMC2702753?pdf=render |
| work_keys_str_mv | AT thomasjubault ldopamedicationinparkinsonsdiseaserestoresactivityinthemotorcorticostriatalloopbutdoesnotmodifythecognitivenetwork AT lauramonetta ldopamedicationinparkinsonsdiseaserestoresactivityinthemotorcorticostriatalloopbutdoesnotmodifythecognitivenetwork AT antoniopstrafella ldopamedicationinparkinsonsdiseaserestoresactivityinthemotorcorticostriatalloopbutdoesnotmodifythecognitivenetwork AT annelouiselafontaine ldopamedicationinparkinsonsdiseaserestoresactivityinthemotorcorticostriatalloopbutdoesnotmodifythecognitivenetwork AT ourymonchi ldopamedicationinparkinsonsdiseaserestoresactivityinthemotorcorticostriatalloopbutdoesnotmodifythecognitivenetwork |