A phase II trial of the FGFR inhibitor pemigatinib in patients with metastatic esophageal–gastric junction/gastric cancer trastuzumab resistant: the FiGhTeR trial

A phase II trial of the FGFR inhibitor pemigatinib in patients with metastatic esophageal–gastric junction/gastric cancer trastuzumab resistant: the FiGhTeR trial

Background: Prognosis of patients affected by metastatic esophageal–gastric junction (EGJ) or gastric cancer (GC) remains dismal. Trastuzumab, an anti-HER2 monoclonal antibody, is the only targeted agent approved for the first-line treatment of patients with HER2-overexpressing advanced EGJ or GC in...

Full description

Bibliographic Details
Main Authors:	Valeria Merz, Camilla Zecchetto, Francesca Simionato, Alessandro Cavaliere, Simona Casalino, Michele Pavarana, Simone Giacopuzzi, Maria Bencivenga, Anna Tomezzoli, Raffaela Santoro, Vita Fedele, Serena Contarelli, Irene Rossi, Serena Giacomazzi, Martina Pasquato, Cristiana Piazzola, Stefano Milleri, Giovanni de Manzoni, Davide Melisi
Format:	Article
Language:	English
Published:	SAGE Publishing 2020-07-01
Series:	Therapeutic Advances in Medical Oncology
Online Access:	https://doi.org/10.1177/1758835920937889

Similar Items

Targeting FGFR Pathway Is Not an Effective Therapeutic Strategy in Patients with Unselected Metastatic Esophagogastric Cancer Resistant to Trastuzumab
by: Camilla Zecchetto, et al.
Published: (2023-03-01)

HOX Genes Family and Cancer: A Novel Role for Homeobox B9 in the Resistance to Anti-Angiogenic Therapies
by: Serena Contarelli, et al.
Published: (2020-11-01)

A phase II study of liposomal irinotecan with 5-fluorouracil, leucovorin and oxaliplatin in patients with resectable pancreatic cancer: the nITRO trial
by: Francesca Simionato, et al.
Published: (2020-09-01)

Targeting KRAS: The Elephant in the Room of Epithelial Cancers
by: Valeria Merz, et al.
Published: (2021-03-01)

Characterization of the cholangiocarcinoma drug pemigatinib against FGFR gatekeeper mutants
by: Qianmeng Lin, et al.
Published: (2022-08-01)

YAP Activation Is Associated with a Worse Prognosis of Poorly Cohesive Gastric Cancer
by: Maria Bencivenga, et al.
Published: (2023-08-01)

Hyperphosphatemic Tumoral Calcinosis With Pemigatinib Use
by: Akshan Puar, MBBS, et al.
Published: (2022-09-01)

Pressurized intraperitoneal aerosol chemotherapy (PIPAC) in multimodal therapy for patients with oligometastatic peritoneal gastric cancer: a randomized multicenter phase III trial PIPAC VEROne
by: Casella Francesco, et al.
Published: (2022-06-01)

Pemigatinib in Intrahepatic Cholangiocarcinoma: A Work in Progress
by: Gennaro Gadaleta-Caldarola, et al.
Published: (2022-10-01)

Pemigatinib for adults with previously treated, locally advanced or metastatic cholangiocarcinoma with FGFR2 fusions/rearrangements
by: Daniel Walden, et al.
Published: (2022-08-01)

The Multifaceted Role of TGF-β in Gastrointestinal Tumors
by: Fabio Sabbadini, et al.
Published: (2021-08-01)

Case report: Pemigatinib-induced retinopathy: a serial examination of subretinal fluid secondary to an FGFR inhibitor
by: Daniel Barmas-Alamdari, et al.
Published: (2024-01-01)

Influence of Tumor Stroma on the Aggressiveness of Poorly Cohesive Gastric Carcinoma
by: Giorgio Malpeli, et al.
Published: (2024-02-01)

Multifocal serous retinopathy with pemigatinib therapy for metastatic colon adenocarcinoma
by: Oleg Alekseev, et al.
Published: (2021-04-01)

Pemigatinib treatment for intrahepatic cholangiocarcinoma with FGFR2 fusion detected by a liquid comprehensive genomic profiling test
by: Shun Ishido, et al.
Published: (2023-07-01)

Integration of liposomal irinotecan in the first-line treatment of metastatic pancreatic cancer: try to do not think about the white bear
by: Davide Melisi, et al.
Published: (2024-04-01)

Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer
by: Serena Battista, et al.
Published: (2021-06-01)

222-L Pemigatinib increases the effectiveness of EpCAM-CAR-T in squamous cell carcinoma
by: Xiaoyu Zhang, et al.
Published: (2023-11-01)

Evaluation of drug–drug interaction potential for pemigatinib using physiologically based pharmacokinetic modeling
by: Tao Ji, et al.
Published: (2022-07-01)

Theoretical investigation, solvation effect, topology, NCI and molecular docking studies on potential Pemigatinib
by: T. Kaviya, et al.
Published: (2023-12-01)

FIGHT‐102: A phase 1 study of pemigatinib in Japanese patients with advanced malignancies
by: Yutaka Fujiwara, et al.
Published: (2023-05-01)

Prospective randomized controlled trial comparing the efficacy and safety of Roux-en-Y gastric bypass and one-anastomosis gastric bypass (the RYSA trial): trial protocol and interim analysis
by: Tuure Saarinen, et al.
Published: (2019-12-01)

Pemigatinib in previously treated Chinese patients with locally advanced or metastatic cholangiocarcinoma carrying FGFR2 fusions or rearrangements: A phase II study
by: Guo‐Ming Shi, et al.
Published: (2023-02-01)

One Anastomosis Gastric Bypass versus Roux-en-Y Gastric Bypass: A Randomized Prospective Trial
by: Servet Karagul, et al.
Published: (2024-02-01)

The Role of Pyloromyotomy on Gastric Drainage in Esophagectomy and Gastric Pull-up Procedures: A Randomized Clinical Trial Study
by: Mohsen Sokouti, et al.
Published: (2015-09-01)

Population pharmacokinetic and exposure‐response analyses of pemigatinib in patients with advanced solid tumors including cholangiocarcinoma
by: Xiaohua Gong, et al.
Published: (2023-11-01)

Clinical experience with pemigatinib for previously treated metastatic cholangiocarcinoma: practical considerations from clinical cases
by: Jonathan Wadsley, et al.
Published: (2023-08-01)

Safety analysis of pemigatinib leveraging the US Food and Drug administration adverse event reporting system
by: Ying Zhang, et al.
Published: (2023-07-01)

Formulation development, optimization and characterization of Pemigatinib-loaded supersaturable self-nanoemulsifying drug delivery systems
by: Muthadi Radhika Reddy, et al.
Published: (2022-11-01)

The pocket book of fighters : the definitive guide to the fighters of the world /
by: 441025 Bowman, Martin
Published: (2004)

Efficacy of an aid (gastric tube insertion guide) for oral insertion of a gastric tube: a randomized controlled trial
by: Shunsuke Saima, et al.
Published: (2023-02-01)

The world's fighters/
by: 206829 King, Horace Frederick
Published: (1971)

Fighter missions/
by: Gunston, Bill
Published: (1988)

Tiny fighter!
by: Chung, Yi Ru, et al.
Published: (2023)

Luring Southeast Asian fighters to IS : the case of former GAM fighters
by: Jasminder Singh
Published: (2015)

A new promising oncogenic target (p.C382R) for treatment with pemigatinib in patients with cholangiocarcinoma
by: Louisa Hempel, et al.
Published: (2022-09-01)

Assessing clinical trial failure risk factors and reasons in gastric cancer
by: Zikai Zhang, et al.
Published: (2022-11-01)

Venous thromboembolism during preoperative chemotherapy in the CRITICS gastric cancer trial
by: Astrid E. Slagter, et al.
Published: (2020-09-01)

State-of-the-Art of Monoclonal Antibodies for the Treatment of Gastric Cancer
by: Basile D, et al.
Published: (2021-11-01)

Stage IV Gastric Cancer: The Surgical Perspective of the Italian Research Group on Gastric Cancer
by: Silvia Ministrini, et al.
Published: (2020-01-01)