LINE-1 ORF1p as a candidate biomarker in high grade serous ovarian carcinoma

LINE-1 ORF1p as a candidate biomarker in high grade serous ovarian carcinoma

Abstract Long interspersed element 1 (LINE-1) open reading frame 1 protein (ORF1p) expression is a common feature of many cancer types, including high-grade serous ovarian carcinoma (HGSOC). Here, we report that ORF1p is not only expressed but also released by ovarian cancer and primary tumor cells....

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Bibliographic Details
Main Authors: Sho Sato, Michael Gillette, Pamela R. de Santiago, Eric Kuhn, Michael Burgess, Kristen Doucette, Yi Feng, Carlos Mendez-Dorantes, Paul J. Ippoliti, Sara Hobday, Marilyn A. Mitchell, Kai Doberstein, Stefan M. Gysler, Michelle S. Hirsch, Lauren Schwartz, Michael J. Birrer, Steven J. Skates, Kathleen H. Burns, Steven A. Carr, Ronny Drapkin
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-28840-5

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