CD52 Is Elevated on B cells of SLE Patients and Regulates B Cell Function

CD52 Is Elevated on B cells of SLE Patients and Regulates B Cell Function

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by B cell dysregulation and breaks in tolerance that lead to the production of pathogenic autoantibodies. We performed single-cell RNA sequencing of B cells from healthy donors and individuals with SLE which revealed upregulat...

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Bibliographic Details
Main Authors: Kartik Bhamidipati, John L. Silberstein, Yashaar Chaichian, Matthew C. Baker, Tobias V. Lanz, Amin Zia, Yusuf S. Rasheed, Jennifer R. Cochran, William H. Robinson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
B cell receptor signaling
B cells
glycoprotein
autoimmunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.626820/full

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