Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice
Sudharshan Reddy D1, Muchandi IS2, Srinivasa Rao A3, Pradeep HA1, Ravi Kumar K1, Srinivasa Rao M1, Mohammed Ibrahim11Nizam Institute of Pharmacy, Hyderabad, Andhra Pradesh, India; 2HSK College of Pharmacy, Bagalkot, Karnataka, India; 3Bhaskar College of Pharmacy, Hyderabad, Andhra Pradesh, IndiaAbst...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2010-04-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/effect-of-holostemma-annularis-on-the-progression-of-diabetes-induced--peer-reviewed-article-DMSO |
| _version_ | 1828044552349417472 |
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| author | Ibrahim M |
| author_facet | Ibrahim M |
| author_sort | Ibrahim M |
| collection | DOAJ |
| description | Sudharshan Reddy D1, Muchandi IS2, Srinivasa Rao A3, Pradeep HA1, Ravi Kumar K1, Srinivasa Rao M1, Mohammed Ibrahim11Nizam Institute of Pharmacy, Hyderabad, Andhra Pradesh, India; 2HSK College of Pharmacy, Bagalkot, Karnataka, India; 3Bhaskar College of Pharmacy, Hyderabad, Andhra Pradesh, IndiaAbstract: The roots of Holostemma annularis K. Schum (Asclepiadacae) are used in traditional medicine to treat diabetes. This medicinal plant, widely used in more than 34 ayurvedic preparations, was evaluated in a high fructose diet in induced insulin resistance and in C57BL/6J ob/ob diabetic mice for its antidiabetic activity. Graded doses of both chloroform and methanolic extracts of the roots of H. annularis were administered to normal and experimental diabetic rats for 21 days. Serum glucose, triglycerides, cholesterol levels and total protein in urine were analyzed. Significant results were observed in the estimated parameters. These data justify the use of the plant in the treatment of diabetes mellitus and is a potential source for the isolation of new active agents for diabetes mellitus.Keywords: Holostemma annularis, high fructose diet, antihyperglycemic, C57BL/6J ob/ob mice |
| first_indexed | 2024-04-10T17:58:12Z |
| format | Article |
| id | doaj.art-4b45d4d4895e41ca9f30f3ea9f63be79 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T17:58:12Z |
| publishDate | 2010-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-4b45d4d4895e41ca9f30f3ea9f63be792023-02-02T17:09:56ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072010-04-01Volume 387944314Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob miceIbrahim MSudharshan Reddy D1, Muchandi IS2, Srinivasa Rao A3, Pradeep HA1, Ravi Kumar K1, Srinivasa Rao M1, Mohammed Ibrahim11Nizam Institute of Pharmacy, Hyderabad, Andhra Pradesh, India; 2HSK College of Pharmacy, Bagalkot, Karnataka, India; 3Bhaskar College of Pharmacy, Hyderabad, Andhra Pradesh, IndiaAbstract: The roots of Holostemma annularis K. Schum (Asclepiadacae) are used in traditional medicine to treat diabetes. This medicinal plant, widely used in more than 34 ayurvedic preparations, was evaluated in a high fructose diet in induced insulin resistance and in C57BL/6J ob/ob diabetic mice for its antidiabetic activity. Graded doses of both chloroform and methanolic extracts of the roots of H. annularis were administered to normal and experimental diabetic rats for 21 days. Serum glucose, triglycerides, cholesterol levels and total protein in urine were analyzed. Significant results were observed in the estimated parameters. These data justify the use of the plant in the treatment of diabetes mellitus and is a potential source for the isolation of new active agents for diabetes mellitus.Keywords: Holostemma annularis, high fructose diet, antihyperglycemic, C57BL/6J ob/ob micehttps://www.dovepress.com/effect-of-holostemma-annularis-on-the-progression-of-diabetes-induced--peer-reviewed-article-DMSOHolostemma annularisHigh fructose dietAnti-hyperglycaemicC57BL/6J ob/ob mice. |
| spellingShingle | Ibrahim M Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice Diabetes, Metabolic Syndrome and Obesity Holostemma annularis High fructose diet Anti-hyperglycaemic C57BL/6J ob/ob mice. |
| title | Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice |
| title_full | Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice |
| title_fullStr | Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice |
| title_full_unstemmed | Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice |
| title_short | Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice |
| title_sort | effect of holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic c57bl 6j ob ob mice |
| topic | Holostemma annularis High fructose diet Anti-hyperglycaemic C57BL/6J ob/ob mice. |
| url | https://www.dovepress.com/effect-of-holostemma-annularis-on-the-progression-of-diabetes-induced--peer-reviewed-article-DMSO |
| work_keys_str_mv | AT ibrahimm effectofholostemmaannularisontheprogressionofdiabetesinducedbyahighfructosedietinratsandindiabeticc57bl6jobobmice |