Two-year changes in body composition and future cardiovascular events: a longitudinal community-based study
Abstract Background The risk of cardiovascular diseases has rapidly increased among middle-aged and elderly. However, little is known about the relationship of body composition changes with the risk of cardiovascular events among this population in China. We explored the associations of 2-year chang...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-01-01
|
| Series: | Nutrition & Metabolism |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12986-023-00727-2 |
| _version_ | 1811171813112152064 |
|---|---|
| author | Tingting Hu Yun Shen Weijie Cao Yiting Xu Yufei Wang Xiaojing Ma Yuqian Bao |
| author_facet | Tingting Hu Yun Shen Weijie Cao Yiting Xu Yufei Wang Xiaojing Ma Yuqian Bao |
| author_sort | Tingting Hu |
| collection | DOAJ |
| description | Abstract Background The risk of cardiovascular diseases has rapidly increased among middle-aged and elderly. However, little is known about the relationship of body composition changes with the risk of cardiovascular events among this population in China. We explored the associations of 2-year changes in fat percentage (fat%) and fat-free mass percentage (FFM%) with subsequent cardiovascular events in a middle-aged and elderly community-based cohort. Methods This study included 1048 participants (456 men [43.51%], aged 50–80 years) without overt cardiovascular disease, who underwent two examinations during 2013–2014 and 2015–2016. All participants were followed up until 2022 for cardiovascular events. A bioelectrical impedance analyzer was used to calculate fat% and FFM% change. Results At baseline, the median body mass index (BMI), fat%, and FFM% were 23.9 (22.1–25.9) kg/m2, 27.2 (20.8–33.6)%, and 72.8 (66.4–79.2)%, respectively. Two-year changes in fat% and FFM% were 0.31 (− 5.53 to 6.87)% and − 0.12 (− 2.36 to 2.06)%. During an average follow-up of 5.5 years, 86 cardiovascular events (8.21%) occurred. Cox regression models showed that hazard ratios (HRs) of every 2% change in fat% and FFM% for cardiovascular events were 1.04 (95% confidence interval [CI] 1.01–1.07) and 0.84 (95% CI 0.74–0.95), respectively. Compared with participants with stable fat% (–2% ≤ ⊿fat% < 2%), those with fat% gain ≥ 2% had an increased risk of cardiovascular events (HR 2.07, 95% CI 1.08–3.97). FFM% loss > 8% was associated with a higher risk of cardiovascular events (HR 3.83, 95% CI 1.29–11.4). Conclusions In a middle-aged and elderly community-based Chinese population, fat% gain or FFM% loss was associated with an increased risk of cardiovascular events. |
| first_indexed | 2024-04-10T17:20:25Z |
| format | Article |
| id | doaj.art-4b4734a155eb452aa12ad63d1eb4134a |
| institution | Directory Open Access Journal |
| issn | 1743-7075 |
| language | English |
| last_indexed | 2024-04-10T17:20:25Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition & Metabolism |
| spelling | doaj.art-4b4734a155eb452aa12ad63d1eb4134a2023-02-05T12:06:19ZengBMCNutrition & Metabolism1743-70752023-01-012011910.1186/s12986-023-00727-2Two-year changes in body composition and future cardiovascular events: a longitudinal community-based studyTingting Hu0Yun Shen1Weijie Cao2Yiting Xu3Yufei Wang4Xiaojing Ma5Yuqian Bao6Department of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes MellitusDepartment of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes MellitusDepartment of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes MellitusDepartment of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes MellitusDepartment of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes MellitusDepartment of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes MellitusDepartment of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes MellitusAbstract Background The risk of cardiovascular diseases has rapidly increased among middle-aged and elderly. However, little is known about the relationship of body composition changes with the risk of cardiovascular events among this population in China. We explored the associations of 2-year changes in fat percentage (fat%) and fat-free mass percentage (FFM%) with subsequent cardiovascular events in a middle-aged and elderly community-based cohort. Methods This study included 1048 participants (456 men [43.51%], aged 50–80 years) without overt cardiovascular disease, who underwent two examinations during 2013–2014 and 2015–2016. All participants were followed up until 2022 for cardiovascular events. A bioelectrical impedance analyzer was used to calculate fat% and FFM% change. Results At baseline, the median body mass index (BMI), fat%, and FFM% were 23.9 (22.1–25.9) kg/m2, 27.2 (20.8–33.6)%, and 72.8 (66.4–79.2)%, respectively. Two-year changes in fat% and FFM% were 0.31 (− 5.53 to 6.87)% and − 0.12 (− 2.36 to 2.06)%. During an average follow-up of 5.5 years, 86 cardiovascular events (8.21%) occurred. Cox regression models showed that hazard ratios (HRs) of every 2% change in fat% and FFM% for cardiovascular events were 1.04 (95% confidence interval [CI] 1.01–1.07) and 0.84 (95% CI 0.74–0.95), respectively. Compared with participants with stable fat% (–2% ≤ ⊿fat% < 2%), those with fat% gain ≥ 2% had an increased risk of cardiovascular events (HR 2.07, 95% CI 1.08–3.97). FFM% loss > 8% was associated with a higher risk of cardiovascular events (HR 3.83, 95% CI 1.29–11.4). Conclusions In a middle-aged and elderly community-based Chinese population, fat% gain or FFM% loss was associated with an increased risk of cardiovascular events.https://doi.org/10.1186/s12986-023-00727-2cardiovascular eventfat percentage changefat-free mass percentage changelongitudinal study |
| spellingShingle | Tingting Hu Yun Shen Weijie Cao Yiting Xu Yufei Wang Xiaojing Ma Yuqian Bao Two-year changes in body composition and future cardiovascular events: a longitudinal community-based study Nutrition & Metabolism cardiovascular event fat percentage change fat-free mass percentage change longitudinal study |
| title | Two-year changes in body composition and future cardiovascular events: a longitudinal community-based study |
| title_full | Two-year changes in body composition and future cardiovascular events: a longitudinal community-based study |
| title_fullStr | Two-year changes in body composition and future cardiovascular events: a longitudinal community-based study |
| title_full_unstemmed | Two-year changes in body composition and future cardiovascular events: a longitudinal community-based study |
| title_short | Two-year changes in body composition and future cardiovascular events: a longitudinal community-based study |
| title_sort | two year changes in body composition and future cardiovascular events a longitudinal community based study |
| topic | cardiovascular event fat percentage change fat-free mass percentage change longitudinal study |
| url | https://doi.org/10.1186/s12986-023-00727-2 |
| work_keys_str_mv | AT tingtinghu twoyearchangesinbodycompositionandfuturecardiovasculareventsalongitudinalcommunitybasedstudy AT yunshen twoyearchangesinbodycompositionandfuturecardiovasculareventsalongitudinalcommunitybasedstudy AT weijiecao twoyearchangesinbodycompositionandfuturecardiovasculareventsalongitudinalcommunitybasedstudy AT yitingxu twoyearchangesinbodycompositionandfuturecardiovasculareventsalongitudinalcommunitybasedstudy AT yufeiwang twoyearchangesinbodycompositionandfuturecardiovasculareventsalongitudinalcommunitybasedstudy AT xiaojingma twoyearchangesinbodycompositionandfuturecardiovasculareventsalongitudinalcommunitybasedstudy AT yuqianbao twoyearchangesinbodycompositionandfuturecardiovasculareventsalongitudinalcommunitybasedstudy |