Lung cancer cells survive epidermal growth factor receptor tyrosine kinase inhibitor exposure through upregulation of cholesterol synthesis

Lung cancer cells survive epidermal growth factor receptor tyrosine kinase inhibitor exposure through upregulation of cholesterol synthesis

Abstract Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) provide clinical benefits over chemotherapy for lung cancer patients with EGFR activating mutations. Despite initial clinical responses, long‐term efficacy is not possible because of acquired resistance to these thera...

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Detaylı Bibliyografya
Asıl Yazarlar: Mark C. Howell, Ryan Green, Roukiah Khalil, Elspeth Foran, Waise Quarni, Rajesh Nair, Stanley Stevens, Aleksandr Grinchuk, Andrew Hanna, Shyam Mohapatra, Subhra Mohapatra
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Wiley 2020-02-01
Seri Bilgileri:FASEB BioAdvances
Konular:
cholesterol
drug tolerance
EGFR TKIs
lung cancer
Online Erişim:https://doi.org/10.1096/fba.2019-00081

Internet

https://doi.org/10.1096/fba.2019-00081

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