Metabolomics unveils the exacerbating role of arachidonic acid metabolism in atherosclerosis
Atherosclerosis is a complex vascular disorder characterized by the deposition of lipids, inflammatory cascades, and plaque formation in arterial walls. A thorough understanding of its causes and progression is necessary to develop effective diagnostic and therapeutic strategies. Recent breakthrough...
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1297437/full |
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| author | Sai Ma Sai Ma Songqing He Songqing He Jing Liu Jing Liu Wei Zhuang Wei Zhuang Hanqing Li Hanqing Li Chen Lin Chen Lin Lijun Wang Lijun Wang Jing Feng Jing Feng Lei Wang Lei Wang |
| author_facet | Sai Ma Sai Ma Songqing He Songqing He Jing Liu Jing Liu Wei Zhuang Wei Zhuang Hanqing Li Hanqing Li Chen Lin Chen Lin Lijun Wang Lijun Wang Jing Feng Jing Feng Lei Wang Lei Wang |
| author_sort | Sai Ma |
| collection | DOAJ |
| description | Atherosclerosis is a complex vascular disorder characterized by the deposition of lipids, inflammatory cascades, and plaque formation in arterial walls. A thorough understanding of its causes and progression is necessary to develop effective diagnostic and therapeutic strategies. Recent breakthroughs in metabolomics have provided valuable insights into the molecular mechanisms and genetic factors involved in atherosclerosis, leading to innovative approaches for preventing and treating the disease. In our study, we analyzed clinical serum samples from both atherosclerosis patients and animal models using laser desorption ionization mass spectrometry. By employing methods such as orthogonal partial least-squares discrimination analysis (OPLS-DA), heatmaps, and volcano plots, we can accurately classify atherosclerosis (AUC = 0.892) and identify key molecules associated with the disease. Specifically, we observed elevated levels of arachidonic acid and its metabolite, leukotriene B4, in atherosclerosis. By inhibiting arachidonic acid and monitoring its downstream metabolites, we discovered the crucial role of this metabolic pathway in regulating atherosclerosis. Metabolomic research provides detailed insights into the metabolic networks involved in atherosclerosis development and reveals the close connection between abnormal metabolism and the disease. These studies offer new possibilities for precise diagnosis, treatment, and monitoring of disease progression, as well as evaluating the effectiveness of therapeutic interventions. |
| first_indexed | 2024-03-08T05:13:04Z |
| format | Article |
| id | doaj.art-4b4898ca54d3485ba7df5c71f5f00d5a |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-03-08T05:13:04Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-4b4898ca54d3485ba7df5c71f5f00d5a2024-02-07T04:54:52ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2024-02-011110.3389/fmolb.2024.12974371297437Metabolomics unveils the exacerbating role of arachidonic acid metabolism in atherosclerosisSai Ma0Sai Ma1Songqing He2Songqing He3Jing Liu4Jing Liu5Wei Zhuang6Wei Zhuang7Hanqing Li8Hanqing Li9Chen Lin10Chen Lin11Lijun Wang12Lijun Wang13Jing Feng14Jing Feng15Lei Wang16Lei Wang17Department of Cardiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Cardiology, The First School of Clinical Medicine, Southern Medical University, Nanjing, ChinaDepartment of Cardiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Cardiology, The First School of Clinical Medicine, Southern Medical University, Nanjing, ChinaDepartment of Cardiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Cardiology, The First School of Clinical Medicine, Southern Medical University, Nanjing, ChinaDepartment of Cardiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Cardiology, The First School of Clinical Medicine, Southern Medical University, Nanjing, ChinaDepartment of Cardiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Cardiology, The First School of Clinical Medicine, Southern Medical University, Nanjing, ChinaDepartment of Cardiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Cardiology, The First School of Clinical Medicine, Southern Medical University, Nanjing, ChinaDepartment of Cardiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Cardiology, The First School of Clinical Medicine, Southern Medical University, Nanjing, ChinaDepartment of Emergency Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Emergency Medicine, The First School of Clinical Medicine, Southern Medical University, Nanjing, ChinaDepartment of Cardiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Cardiology, The First School of Clinical Medicine, Southern Medical University, Nanjing, ChinaAtherosclerosis is a complex vascular disorder characterized by the deposition of lipids, inflammatory cascades, and plaque formation in arterial walls. A thorough understanding of its causes and progression is necessary to develop effective diagnostic and therapeutic strategies. Recent breakthroughs in metabolomics have provided valuable insights into the molecular mechanisms and genetic factors involved in atherosclerosis, leading to innovative approaches for preventing and treating the disease. In our study, we analyzed clinical serum samples from both atherosclerosis patients and animal models using laser desorption ionization mass spectrometry. By employing methods such as orthogonal partial least-squares discrimination analysis (OPLS-DA), heatmaps, and volcano plots, we can accurately classify atherosclerosis (AUC = 0.892) and identify key molecules associated with the disease. Specifically, we observed elevated levels of arachidonic acid and its metabolite, leukotriene B4, in atherosclerosis. By inhibiting arachidonic acid and monitoring its downstream metabolites, we discovered the crucial role of this metabolic pathway in regulating atherosclerosis. Metabolomic research provides detailed insights into the metabolic networks involved in atherosclerosis development and reveals the close connection between abnormal metabolism and the disease. These studies offer new possibilities for precise diagnosis, treatment, and monitoring of disease progression, as well as evaluating the effectiveness of therapeutic interventions.https://www.frontiersin.org/articles/10.3389/fmolb.2024.1297437/fullatherosclerosismetabolomicsexacerbating rolemetabolismarachidonic acid |
| spellingShingle | Sai Ma Sai Ma Songqing He Songqing He Jing Liu Jing Liu Wei Zhuang Wei Zhuang Hanqing Li Hanqing Li Chen Lin Chen Lin Lijun Wang Lijun Wang Jing Feng Jing Feng Lei Wang Lei Wang Metabolomics unveils the exacerbating role of arachidonic acid metabolism in atherosclerosis Frontiers in Molecular Biosciences atherosclerosis metabolomics exacerbating role metabolism arachidonic acid |
| title | Metabolomics unveils the exacerbating role of arachidonic acid metabolism in atherosclerosis |
| title_full | Metabolomics unveils the exacerbating role of arachidonic acid metabolism in atherosclerosis |
| title_fullStr | Metabolomics unveils the exacerbating role of arachidonic acid metabolism in atherosclerosis |
| title_full_unstemmed | Metabolomics unveils the exacerbating role of arachidonic acid metabolism in atherosclerosis |
| title_short | Metabolomics unveils the exacerbating role of arachidonic acid metabolism in atherosclerosis |
| title_sort | metabolomics unveils the exacerbating role of arachidonic acid metabolism in atherosclerosis |
| topic | atherosclerosis metabolomics exacerbating role metabolism arachidonic acid |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1297437/full |
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