Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival

Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival

Organisms must execute metabolic defenses to survive nutrient deprivation. We performed a genome-wide RNAi screen in Caenorhabditis elegans to identify fat regulatory genes indispensable for starvation resistance. Here, we show that opposing proteostasis pathways are principal determinants of starva...

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Bibliographic Details
Main Authors: Christopher M. Webster, Elizabeth C. Pino, Christopher E. Carr, Lianfeng Wu, Ben Zhou, Lucydalila Cedillo, Michael C. Kacergis, Sean P. Curran, Alexander A. Soukas
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
C. elegans
fat
lipid
metabolism
nutrient deprivation
starvation survival
AMPK
proteasome
amino-acyl tRNA synthetases
proteostatis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717308999

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