Platelets can reflect the severity of Crohn's disease without the effect of anemia
OBJECTIVES: Anemia and changes in platelets (PLT) are common in inflammatory bowel disease (IBD). In our study, we aimed to verify whether PLT count can independently reflect the severity of IBD. METHODS: In our hospital, 137 Crohn’s Disease (CD), 69 Ulcerative colitis (UC) patients, and 412 health...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2020-07-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100246&tlng=en |
| _version_ | 1811229639944699904 |
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| author | Lin Li Ping Xu Zhongchen Zhang Xinxin Zhou Chunxiao Chen Chao Lu |
| author_facet | Lin Li Ping Xu Zhongchen Zhang Xinxin Zhou Chunxiao Chen Chao Lu |
| author_sort | Lin Li |
| collection | DOAJ |
| description | OBJECTIVES: Anemia and changes in platelets (PLT) are common in inflammatory bowel disease (IBD). In our study, we aimed to verify whether PLT count can independently reflect the severity of IBD. METHODS: In our hospital, 137 Crohn’s Disease (CD), 69 Ulcerative colitis (UC) patients, and 412 healthy controls were included to compare the differences in PLT count. In addition, the effect of anemia, C-reactive protein (CRP), age, CD activity index (CDAI) or Mayo on PLTs was also analyzed. If PLTs independently affected CD or UC, we used the receiver operating characteristic (ROC) curve to verify the diagnostic value and obtain the cut-off value of PLT. RESULTS: CD and UC patients had higher PLT than controls (p<0.001, p<0.001; respectively). In CD patients, the results showed that patients with anemia (P<0.01), Iron Deficiency Anemia (IDA) (p<0.001), CRP≥8 mg/L (p=0.046), and CDAI≥150 (p<0.001) had higher PLT, while in UC patients, those with anemia (p=0.018), CRP≥8 mg/L (p=0.045), and Mayo≥3 (p=0.029) had higher PLT. Univariate analysis showed that CDAI was positively correlated with PLT count (p<0.001), while hemoglobin (p=0.001) and age (p<0.001) were negatively correlated with PLT in CD. In UC patients, Mayo (p=0.001) and CRP (p<0.001) were positively correlated with PLT, while hemoglobin (p=0.002) was negatively correlated. Finally, by linear stepwise multivariate analysis, we clarified the positive relationship between PLT and CD (p<0.001) by eliminating the interference of hemoglobin, and determined the cut-off value of PLT as 298×109/L. For UC, we did not obtain similar results. CONCLUSIONS: PLT can be an indicator of disease severity in CD, while there is a lack of evidence regarding this finding in UC. |
| first_indexed | 2024-04-12T10:16:45Z |
| format | Article |
| id | doaj.art-4b4ded78ae254d7e8d52841efad4f040 |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-04-12T10:16:45Z |
| publishDate | 2020-07-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-4b4ded78ae254d7e8d52841efad4f0402022-12-22T03:37:11ZengElsevier EspañaClinics1980-53222020-07-017510.6061/clinics/2020/e1596Platelets can reflect the severity of Crohn's disease without the effect of anemiaLin LiPing XuZhongchen ZhangXinxin ZhouChunxiao Chenhttps://orcid.org/0000-0002-3511-1822Chao Luhttps://orcid.org/0000-0002-1265-0903OBJECTIVES: Anemia and changes in platelets (PLT) are common in inflammatory bowel disease (IBD). In our study, we aimed to verify whether PLT count can independently reflect the severity of IBD. METHODS: In our hospital, 137 Crohn’s Disease (CD), 69 Ulcerative colitis (UC) patients, and 412 healthy controls were included to compare the differences in PLT count. In addition, the effect of anemia, C-reactive protein (CRP), age, CD activity index (CDAI) or Mayo on PLTs was also analyzed. If PLTs independently affected CD or UC, we used the receiver operating characteristic (ROC) curve to verify the diagnostic value and obtain the cut-off value of PLT. RESULTS: CD and UC patients had higher PLT than controls (p<0.001, p<0.001; respectively). In CD patients, the results showed that patients with anemia (P<0.01), Iron Deficiency Anemia (IDA) (p<0.001), CRP≥8 mg/L (p=0.046), and CDAI≥150 (p<0.001) had higher PLT, while in UC patients, those with anemia (p=0.018), CRP≥8 mg/L (p=0.045), and Mayo≥3 (p=0.029) had higher PLT. Univariate analysis showed that CDAI was positively correlated with PLT count (p<0.001), while hemoglobin (p=0.001) and age (p<0.001) were negatively correlated with PLT in CD. In UC patients, Mayo (p=0.001) and CRP (p<0.001) were positively correlated with PLT, while hemoglobin (p=0.002) was negatively correlated. Finally, by linear stepwise multivariate analysis, we clarified the positive relationship between PLT and CD (p<0.001) by eliminating the interference of hemoglobin, and determined the cut-off value of PLT as 298×109/L. For UC, we did not obtain similar results. CONCLUSIONS: PLT can be an indicator of disease severity in CD, while there is a lack of evidence regarding this finding in UC.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100246&tlng=enPlateletAnemiaCrohn's DiseaseUlcerative Colitis |
| spellingShingle | Lin Li Ping Xu Zhongchen Zhang Xinxin Zhou Chunxiao Chen Chao Lu Platelets can reflect the severity of Crohn's disease without the effect of anemia Clinics Platelet Anemia Crohn's Disease Ulcerative Colitis |
| title | Platelets can reflect the severity of Crohn's disease without the effect of anemia |
| title_full | Platelets can reflect the severity of Crohn's disease without the effect of anemia |
| title_fullStr | Platelets can reflect the severity of Crohn's disease without the effect of anemia |
| title_full_unstemmed | Platelets can reflect the severity of Crohn's disease without the effect of anemia |
| title_short | Platelets can reflect the severity of Crohn's disease without the effect of anemia |
| title_sort | platelets can reflect the severity of crohn s disease without the effect of anemia |
| topic | Platelet Anemia Crohn's Disease Ulcerative Colitis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100246&tlng=en |
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