What Are the Neural Correlates of Impaired Awareness of Social Cognition and Function in Dementia? A Systematic Review
Deficits in social cognition and function are characteristic of dementia, commonly accompanied by a loss of awareness of the presence or extent of these deficits. This lack of awareness can impair social relationships, increase patients’ and carers’ burden, and contribute to increased rates of insti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/9/1136 |
| _version_ | 1827662852150788096 |
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| author | Anna Hengstschläger Andrew Sommerlad Jonathan Huntley |
| author_facet | Anna Hengstschläger Andrew Sommerlad Jonathan Huntley |
| author_sort | Anna Hengstschläger |
| collection | DOAJ |
| description | Deficits in social cognition and function are characteristic of dementia, commonly accompanied by a loss of awareness of the presence or extent of these deficits. This lack of awareness can impair social relationships, increase patients’ and carers’ burden, and contribute to increased rates of institutionalization. Despite clinical importance, neural correlates of this complex phenomenon remain unclear. We conducted a systematic search of five electronic databases to identify functional and structural neuroimaging studies investigating the neural correlates of impaired awareness of social cognition and function in any dementia type. We rated study quality and conducted a narrative synthesis of the results of the eight studies that met the predefined eligibility criteria. Across these studies, deficits in awareness of impairments in social cognition and function were associated with structural or functional abnormalities in the frontal pole, orbitofrontal cortex, temporal pole, middle temporal gyrus, inferior temporal gyrus, fusiform gyrus, amygdala, hippocampus, parahippocampal gyrus, and insula. Several identified regions overlap with established neural correlates of social cognition. More research is needed to understand awareness of social cognition and function and how this becomes impaired in dementia to improve neuroscientific understanding, aid the identification of this problematic symptom, and target interventions to reduce burden and improve care. |
| first_indexed | 2024-03-10T00:34:19Z |
| format | Article |
| id | doaj.art-4b4e69dde7e046da8868bce55cfe7d35 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T00:34:19Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-4b4e69dde7e046da8868bce55cfe7d352023-11-23T15:19:48ZengMDPI AGBrain Sciences2076-34252022-08-01129113610.3390/brainsci12091136What Are the Neural Correlates of Impaired Awareness of Social Cognition and Function in Dementia? A Systematic ReviewAnna Hengstschläger0Andrew Sommerlad1Jonathan Huntley2Division of Psychiatry, University College London, London W1T 7BN, UKDivision of Psychiatry, University College London, London W1T 7BN, UKDivision of Psychiatry, University College London, London W1T 7BN, UKDeficits in social cognition and function are characteristic of dementia, commonly accompanied by a loss of awareness of the presence or extent of these deficits. This lack of awareness can impair social relationships, increase patients’ and carers’ burden, and contribute to increased rates of institutionalization. Despite clinical importance, neural correlates of this complex phenomenon remain unclear. We conducted a systematic search of five electronic databases to identify functional and structural neuroimaging studies investigating the neural correlates of impaired awareness of social cognition and function in any dementia type. We rated study quality and conducted a narrative synthesis of the results of the eight studies that met the predefined eligibility criteria. Across these studies, deficits in awareness of impairments in social cognition and function were associated with structural or functional abnormalities in the frontal pole, orbitofrontal cortex, temporal pole, middle temporal gyrus, inferior temporal gyrus, fusiform gyrus, amygdala, hippocampus, parahippocampal gyrus, and insula. Several identified regions overlap with established neural correlates of social cognition. More research is needed to understand awareness of social cognition and function and how this becomes impaired in dementia to improve neuroscientific understanding, aid the identification of this problematic symptom, and target interventions to reduce burden and improve care.https://www.mdpi.com/2076-3425/12/9/1136dementiasocial cognitionsocial functionawarenessneuroimaging |
| spellingShingle | Anna Hengstschläger Andrew Sommerlad Jonathan Huntley What Are the Neural Correlates of Impaired Awareness of Social Cognition and Function in Dementia? A Systematic Review Brain Sciences dementia social cognition social function awareness neuroimaging |
| title | What Are the Neural Correlates of Impaired Awareness of Social Cognition and Function in Dementia? A Systematic Review |
| title_full | What Are the Neural Correlates of Impaired Awareness of Social Cognition and Function in Dementia? A Systematic Review |
| title_fullStr | What Are the Neural Correlates of Impaired Awareness of Social Cognition and Function in Dementia? A Systematic Review |
| title_full_unstemmed | What Are the Neural Correlates of Impaired Awareness of Social Cognition and Function in Dementia? A Systematic Review |
| title_short | What Are the Neural Correlates of Impaired Awareness of Social Cognition and Function in Dementia? A Systematic Review |
| title_sort | what are the neural correlates of impaired awareness of social cognition and function in dementia a systematic review |
| topic | dementia social cognition social function awareness neuroimaging |
| url | https://www.mdpi.com/2076-3425/12/9/1136 |
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