Structural and Functional Insights into GID/CTLH E3 Ligase Complexes

Structural and Functional Insights into GID/CTLH E3 Ligase Complexes

Multi-subunit E3 ligases facilitate ubiquitin transfer by coordinating various substrate receptor subunits with a single catalytic center. Small molecules inducing targeted protein degradation have exploited such complexes, proving successful as therapeutics against previously undruggable targets. T...

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Bibliographic Details
Main Authors:	Matthew E. R. Maitland, Gilles A. Lajoie, Gary S. Shaw, Caroline Schild-Poulter
Format:	Article
Language:	English
Published:	MDPI AG 2022-05-01
Series:	International Journal of Molecular Sciences
Subjects:	CTLH complex GID complex E3 ligase ubiquitination RanBP9/RanBPM GID4
Online Access:	https://www.mdpi.com/1422-0067/23/11/5863

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