Paediatric Partial-Thickness Burn Therapy: A Meta-Analysis and Systematic Review of Randomised Controlled Trials
Background: Paediatric second-degree burn injuries are a significant source of medical challenges to the population that may cause severe, lifelong complications. Currently, there are dozens of therapeutic modalities and we aimed to summarise their reported outcomes and determine their effectiveness...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/5/619 |
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| author | Aba Lőrincz Alex Váradi Péter Hegyi Zoltán Rumbus Máté Tuba Anna Gabriella Lamberti Margit Varjú-Solymár Andrea Párniczky Bálint Erőss András Garami Gergő Józsa |
| author_facet | Aba Lőrincz Alex Váradi Péter Hegyi Zoltán Rumbus Máté Tuba Anna Gabriella Lamberti Margit Varjú-Solymár Andrea Párniczky Bálint Erőss András Garami Gergő Józsa |
| author_sort | Aba Lőrincz |
| collection | DOAJ |
| description | Background: Paediatric second-degree burn injuries are a significant source of medical challenges to the population that may cause severe, lifelong complications. Currently, there are dozens of therapeutic modalities and we aimed to summarise their reported outcomes and determine their effectiveness, compared to the widely used silver sulphadiazine (SSD). Methods: We conducted the meta-analysis and systematic review of randomised controlled trials (RCTs), which investigated the performance of dressings in acute paediatric partial-thickness burns. The evaluated endpoints were time until wound closure, grafting and infection rate, number of dressing changes and length of hospitalisation. Results: Twenty-nine RCTs were included in the qualitative and 25 in the quantitative synthesis, but only three trials compared SSD directly to the same intervention (Biobrane). Data analysis showed a tendency for faster healing times and a reduced complication rate linked to biosynthetic, silver foam and amnion membrane dressings. A substantial difference was found between the number of dressing changes associated with less pain, narcosis and treatment duration. Conclusions: Considerable between-study heterogeneity was caused by the unequal depth subcategory ratio and surface area of the injuries; therefore, no significant difference was found in the main outcomes. Further research is necessary to establish the most effective treatment for these burns. |
| first_indexed | 2024-03-10T03:34:38Z |
| format | Article |
| id | doaj.art-4b52200b6e8d4ac6af96c3f0a1605ef6 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T03:34:38Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-4b52200b6e8d4ac6af96c3f0a1605ef62023-11-23T11:48:53ZengMDPI AGLife2075-17292022-04-0112561910.3390/life12050619Paediatric Partial-Thickness Burn Therapy: A Meta-Analysis and Systematic Review of Randomised Controlled TrialsAba Lőrincz0Alex Váradi1Péter Hegyi2Zoltán Rumbus3Máté Tuba4Anna Gabriella Lamberti5Margit Varjú-Solymár6Andrea Párniczky7Bálint Erőss8András Garami9Gergő Józsa10Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti Street, H7624 Pécs, HungaryDepartment of Biostatistics, Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti Street, H7624 Pécs, HungaryInstitute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, 20 Ifjúság Street, H7624 Pécs, HungaryDepartment of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti Street, H7624 Pécs, HungaryDepartment of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti Street, H7624 Pécs, HungaryDepartment of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti Street, H7624 Pécs, HungaryInstitute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, 20 Ifjúság Street, H7624 Pécs, HungaryInstitute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, 20 Ifjúság Street, H7624 Pécs, HungaryInstitute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, 20 Ifjúság Street, H7624 Pécs, HungaryDepartment of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti Street, H7624 Pécs, HungaryDepartment of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti Street, H7624 Pécs, HungaryBackground: Paediatric second-degree burn injuries are a significant source of medical challenges to the population that may cause severe, lifelong complications. Currently, there are dozens of therapeutic modalities and we aimed to summarise their reported outcomes and determine their effectiveness, compared to the widely used silver sulphadiazine (SSD). Methods: We conducted the meta-analysis and systematic review of randomised controlled trials (RCTs), which investigated the performance of dressings in acute paediatric partial-thickness burns. The evaluated endpoints were time until wound closure, grafting and infection rate, number of dressing changes and length of hospitalisation. Results: Twenty-nine RCTs were included in the qualitative and 25 in the quantitative synthesis, but only three trials compared SSD directly to the same intervention (Biobrane). Data analysis showed a tendency for faster healing times and a reduced complication rate linked to biosynthetic, silver foam and amnion membrane dressings. A substantial difference was found between the number of dressing changes associated with less pain, narcosis and treatment duration. Conclusions: Considerable between-study heterogeneity was caused by the unequal depth subcategory ratio and surface area of the injuries; therefore, no significant difference was found in the main outcomes. Further research is necessary to establish the most effective treatment for these burns.https://www.mdpi.com/2075-1729/12/5/619paediatric second-degree burnsilver sulphadiazinesilver foambiosynthetic dressingskin substitutes |
| spellingShingle | Aba Lőrincz Alex Váradi Péter Hegyi Zoltán Rumbus Máté Tuba Anna Gabriella Lamberti Margit Varjú-Solymár Andrea Párniczky Bálint Erőss András Garami Gergő Józsa Paediatric Partial-Thickness Burn Therapy: A Meta-Analysis and Systematic Review of Randomised Controlled Trials Life paediatric second-degree burn silver sulphadiazine silver foam biosynthetic dressing skin substitutes |
| title | Paediatric Partial-Thickness Burn Therapy: A Meta-Analysis and Systematic Review of Randomised Controlled Trials |
| title_full | Paediatric Partial-Thickness Burn Therapy: A Meta-Analysis and Systematic Review of Randomised Controlled Trials |
| title_fullStr | Paediatric Partial-Thickness Burn Therapy: A Meta-Analysis and Systematic Review of Randomised Controlled Trials |
| title_full_unstemmed | Paediatric Partial-Thickness Burn Therapy: A Meta-Analysis and Systematic Review of Randomised Controlled Trials |
| title_short | Paediatric Partial-Thickness Burn Therapy: A Meta-Analysis and Systematic Review of Randomised Controlled Trials |
| title_sort | paediatric partial thickness burn therapy a meta analysis and systematic review of randomised controlled trials |
| topic | paediatric second-degree burn silver sulphadiazine silver foam biosynthetic dressing skin substitutes |
| url | https://www.mdpi.com/2075-1729/12/5/619 |
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