| Summary: | A library of aryl urea oxazole-pyrimidine derivatives (12a-j) have been synthesized and investigated for their anticancer activity profile against a panel of four human cancer cell lines including breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205) and ovarian cancer (A2780) by utilizing of MTT method, compare with etoposide used as reference drug candidate. All the examined compounds displayed potent anticancer activity with IC50 values ranges from 0.01 ± 0.0062 µM to 10.6 ± 7.43 µM, whereas, etoposide showed values ranges from 0.17 ± 0.034 µM to 3.34 ± 0.152 µM. Among the synthesized compounds, seven compounds 12a, 12b, 12d, 12e, 12f, 12 g and 12 h demonstrated most promising activity than reference drug.
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