Design, synthesis and biological evaluation of aryl urea derivatives of oxazole-pyrimidine as anticancer agents
A library of aryl urea oxazole-pyrimidine derivatives (12a-j) have been synthesized and investigated for their anticancer activity profile against a panel of four human cancer cell lines including breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205) and ovarian cancer (A2780) by utiliz...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715624001383 |
| _version_ | 1797244974308261888 |
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| author | Veeranjaneyulu Pattabi Madhu Raju Veeraboina Laxminarayana Eppakayala Srinivasu Navuluri Naveen Mulakayala |
| author_facet | Veeranjaneyulu Pattabi Madhu Raju Veeraboina Laxminarayana Eppakayala Srinivasu Navuluri Naveen Mulakayala |
| author_sort | Veeranjaneyulu Pattabi |
| collection | DOAJ |
| description | A library of aryl urea oxazole-pyrimidine derivatives (12a-j) have been synthesized and investigated for their anticancer activity profile against a panel of four human cancer cell lines including breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205) and ovarian cancer (A2780) by utilizing of MTT method, compare with etoposide used as reference drug candidate. All the examined compounds displayed potent anticancer activity with IC50 values ranges from 0.01 ± 0.0062 µM to 10.6 ± 7.43 µM, whereas, etoposide showed values ranges from 0.17 ± 0.034 µM to 3.34 ± 0.152 µM. Among the synthesized compounds, seven compounds 12a, 12b, 12d, 12e, 12f, 12 g and 12 h demonstrated most promising activity than reference drug. |
| first_indexed | 2024-04-24T19:19:32Z |
| format | Article |
| id | doaj.art-4b52fb916ef1496fa61601a77723fbdf |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-04-24T19:19:32Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-4b52fb916ef1496fa61601a77723fbdf2024-03-26T04:26:44ZengElsevierResults in Chemistry2211-71562024-01-017101442Design, synthesis and biological evaluation of aryl urea derivatives of oxazole-pyrimidine as anticancer agentsVeeranjaneyulu Pattabi0Madhu Raju Veeraboina1Laxminarayana Eppakayala2Srinivasu Navuluri3Naveen Mulakayala4Division of Chemistry, Department of Sciences and Humanities, Vignan’s Foundation for Science, Technology and Research (VFSTR) (deemed to be) University, Vadlamudi, Guntur 522 213, India; SVAK Life Sciences, ALEAP Industrial Area, Pragathi Nagar, Hyderabad 500090, IndiaDivision of Chemistry, Department of Sciences and Humanities, Vignan’s Foundation for Science, Technology and Research (VFSTR) (deemed to be) University, Vadlamudi, Guntur 522 213, India; SVAK Life Sciences, ALEAP Industrial Area, Pragathi Nagar, Hyderabad 500090, IndiaDepartment of Chemistry, Sreenidhi Institute of Science and Technology, Yamnampet, Ghatkesar, Hyderabad 501301 IndiaDivision of Chemistry, Department of Sciences and Humanities, Vignan’s Foundation for Science, Technology and Research (VFSTR) (deemed to be) University, Vadlamudi, Guntur 522 213, India; Corresponding authors.SVAK Life Sciences, ALEAP Industrial Area, Pragathi Nagar, Hyderabad 500090, India; Corresponding authors.A library of aryl urea oxazole-pyrimidine derivatives (12a-j) have been synthesized and investigated for their anticancer activity profile against a panel of four human cancer cell lines including breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205) and ovarian cancer (A2780) by utilizing of MTT method, compare with etoposide used as reference drug candidate. All the examined compounds displayed potent anticancer activity with IC50 values ranges from 0.01 ± 0.0062 µM to 10.6 ± 7.43 µM, whereas, etoposide showed values ranges from 0.17 ± 0.034 µM to 3.34 ± 0.152 µM. Among the synthesized compounds, seven compounds 12a, 12b, 12d, 12e, 12f, 12 g and 12 h demonstrated most promising activity than reference drug.http://www.sciencedirect.com/science/article/pii/S2211715624001383InfigratinibPyrimidineSorafenibUrea and anticancer activity |
| spellingShingle | Veeranjaneyulu Pattabi Madhu Raju Veeraboina Laxminarayana Eppakayala Srinivasu Navuluri Naveen Mulakayala Design, synthesis and biological evaluation of aryl urea derivatives of oxazole-pyrimidine as anticancer agents Results in Chemistry Infigratinib Pyrimidine Sorafenib Urea and anticancer activity |
| title | Design, synthesis and biological evaluation of aryl urea derivatives of oxazole-pyrimidine as anticancer agents |
| title_full | Design, synthesis and biological evaluation of aryl urea derivatives of oxazole-pyrimidine as anticancer agents |
| title_fullStr | Design, synthesis and biological evaluation of aryl urea derivatives of oxazole-pyrimidine as anticancer agents |
| title_full_unstemmed | Design, synthesis and biological evaluation of aryl urea derivatives of oxazole-pyrimidine as anticancer agents |
| title_short | Design, synthesis and biological evaluation of aryl urea derivatives of oxazole-pyrimidine as anticancer agents |
| title_sort | design synthesis and biological evaluation of aryl urea derivatives of oxazole pyrimidine as anticancer agents |
| topic | Infigratinib Pyrimidine Sorafenib Urea and anticancer activity |
| url | http://www.sciencedirect.com/science/article/pii/S2211715624001383 |
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