LuxS and quorum-sensing in Campylobacter
Several intercellular bacterial communication mechanisms have been identified in a broad range of bacterial species. These systems, collectively termed quorum-sensing systems, have been demonstrated to play significant roles in a variety of bacterial processes including motility, biofilm formation,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-03-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00022/full |
| _version_ | 1828861734878707712 |
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| author | Paul ePlummer Paul ePlummer |
| author_facet | Paul ePlummer Paul ePlummer |
| author_sort | Paul ePlummer |
| collection | DOAJ |
| description | Several intercellular bacterial communication mechanisms have been identified in a broad range of bacterial species. These systems, collectively termed quorum-sensing systems, have been demonstrated to play significant roles in a variety of bacterial processes including motility, biofilm formation, expression of virulence genes and animal colonization. Campylobacter jejuni is known to poses a LuxS/ autoinducer-2 mediated system that has been partially characterized over the last decade. AI-2 is formed as a byproduct of the activated methyl recycling pathway, specifically by the LuxS enzyme. Previous work in our laboratory and that of others has demonstrated that this gene is involved in a variety of physiologic pathways of C. jejuni including motility, autoagglutination, CDT expression, flagellar expression, oxidative stress and animal colonization. This review article will summarize the current research associated with LuxS in C. jejuni and will provide insights into the role of this system in the metabolism and intercellular communication of this organism. Additionally, the evidence for other quorum sensing pathways in Campylobacter will be discussed. |
| first_indexed | 2024-12-13T03:07:54Z |
| format | Article |
| id | doaj.art-4b53f85c0d1c45d0973692b6d6486a79 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-13T03:07:54Z |
| publishDate | 2012-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-4b53f85c0d1c45d0973692b6d6486a792022-12-22T00:01:40ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882012-03-01210.3389/fcimb.2012.0002218106LuxS and quorum-sensing in CampylobacterPaul ePlummer0Paul ePlummer1Iowa State UniversityIowa State UniversitySeveral intercellular bacterial communication mechanisms have been identified in a broad range of bacterial species. These systems, collectively termed quorum-sensing systems, have been demonstrated to play significant roles in a variety of bacterial processes including motility, biofilm formation, expression of virulence genes and animal colonization. Campylobacter jejuni is known to poses a LuxS/ autoinducer-2 mediated system that has been partially characterized over the last decade. AI-2 is formed as a byproduct of the activated methyl recycling pathway, specifically by the LuxS enzyme. Previous work in our laboratory and that of others has demonstrated that this gene is involved in a variety of physiologic pathways of C. jejuni including motility, autoagglutination, CDT expression, flagellar expression, oxidative stress and animal colonization. This review article will summarize the current research associated with LuxS in C. jejuni and will provide insights into the role of this system in the metabolism and intercellular communication of this organism. Additionally, the evidence for other quorum sensing pathways in Campylobacter will be discussed.http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00022/fullCampylobacterVirulenceLuxSHSLquorum-sensingAI-2 |
| spellingShingle | Paul ePlummer Paul ePlummer LuxS and quorum-sensing in Campylobacter Frontiers in Cellular and Infection Microbiology Campylobacter Virulence LuxS HSL quorum-sensing AI-2 |
| title | LuxS and quorum-sensing in Campylobacter |
| title_full | LuxS and quorum-sensing in Campylobacter |
| title_fullStr | LuxS and quorum-sensing in Campylobacter |
| title_full_unstemmed | LuxS and quorum-sensing in Campylobacter |
| title_short | LuxS and quorum-sensing in Campylobacter |
| title_sort | luxs and quorum sensing in campylobacter |
| topic | Campylobacter Virulence LuxS HSL quorum-sensing AI-2 |
| url | http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00022/full |
| work_keys_str_mv | AT pauleplummer luxsandquorumsensingincampylobacter AT pauleplummer luxsandquorumsensingincampylobacter |