Study of Chromosomal Abnormalities in Couples with Recurrent Spontaneous Abortions (RSA) in Ardabil Province
Background & objectives: The spontaneous abortion, loss of the fetus until the twentieth week of pregnancy, is one of the most common medical problems in reproductive age. Approximately 15 to 20 percent of all clinically recognized pregnancies lead to abortion. Failure in pregnancy involves econ...
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| Format: | Article |
| Language: | fas |
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Ardabil University of Medical Sciences
2018-04-01
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| Series: | Journal of Ardabil University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jarums.arums.ac.ir/browse.php?a_code=A-10-607-92&slc_lang=en&sid=1 |
| _version_ | 1818112599049371648 |
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| author | Ziba Jahani Seyyed saeid Hosseini Asl Homa Akhavan |
| author_facet | Ziba Jahani Seyyed saeid Hosseini Asl Homa Akhavan |
| author_sort | Ziba Jahani |
| collection | DOAJ |
| description | Background & objectives: The spontaneous abortion, loss of the fetus until the twentieth week of pregnancy, is one of the most common medical problems in reproductive age. Approximately 15 to 20 percent of all clinically recognized pregnancies lead to abortion. Failure in pregnancy involves economic costs, physical and mental problems for the family and the society. Recurrent spontaneous abortion is a multifactorial phenomenon and this study analyzed chromosomal abnormalities and the prevalence of consanguineous marriages in parents with recurrent spontaneous abortions in Ardabil province.
Methods: A total of 350 patients with at least two spontaneous abortions were analyzed using GTG-banding cytogenetic technique.
Results: Parental chromosomal abnormalities were found in 18 cases (10.28% of couples). Most of abnormalities were structural (72.2%). chromosomal aberrations were found in 10 (55.6%) females and 8 (44.4%) males. Translocations were the most common chromosomal abnormalities (55.6 %) diagnosed in this study. Also, there was a significant correlation between recurrent spontaneous abortion due to consanguineous marriage and chromosomal abnormalities (p<0.05).
Conclusion: According to the significant correlation between recurrent spontaneous abortion and chromosomal abnormalities in this study and previous studies, and also the high rate of consanguineous marriages in Ardabil province population, analysis of chromosomal abnormalities is necessary after genetic counseling for both parents with recurrent spontaneous abortions.
Keywords: Recurrent Spontaneous Abortion; Chromosomal Abnormalities; Consanguineous |
| first_indexed | 2024-12-11T03:21:30Z |
| format | Article |
| id | doaj.art-4b54618589804503a863057dc94a030a |
| institution | Directory Open Access Journal |
| issn | 2228-7280 2228-7299 |
| language | fas |
| last_indexed | 2024-12-11T03:21:30Z |
| publishDate | 2018-04-01 |
| publisher | Ardabil University of Medical Sciences |
| record_format | Article |
| series | Journal of Ardabil University of Medical Sciences |
| spelling | doaj.art-4b54618589804503a863057dc94a030a2022-12-22T01:22:37ZfasArdabil University of Medical SciencesJournal of Ardabil University of Medical Sciences2228-72802228-72992018-04-0118191107Study of Chromosomal Abnormalities in Couples with Recurrent Spontaneous Abortions (RSA) in Ardabil ProvinceZiba Jahani0Seyyed saeid Hosseini Asl1Homa Akhavan2 Department of Genetics, School of Sciences, Rey Branch, Payame Noor University, Tehran, Iran Laboratory of Medical Genetics, Imam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil, Iran. Laboratory of Medical Genetics, Imam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil, Iran. Background & objectives: The spontaneous abortion, loss of the fetus until the twentieth week of pregnancy, is one of the most common medical problems in reproductive age. Approximately 15 to 20 percent of all clinically recognized pregnancies lead to abortion. Failure in pregnancy involves economic costs, physical and mental problems for the family and the society. Recurrent spontaneous abortion is a multifactorial phenomenon and this study analyzed chromosomal abnormalities and the prevalence of consanguineous marriages in parents with recurrent spontaneous abortions in Ardabil province. Methods: A total of 350 patients with at least two spontaneous abortions were analyzed using GTG-banding cytogenetic technique. Results: Parental chromosomal abnormalities were found in 18 cases (10.28% of couples). Most of abnormalities were structural (72.2%). chromosomal aberrations were found in 10 (55.6%) females and 8 (44.4%) males. Translocations were the most common chromosomal abnormalities (55.6 %) diagnosed in this study. Also, there was a significant correlation between recurrent spontaneous abortion due to consanguineous marriage and chromosomal abnormalities (p<0.05). Conclusion: According to the significant correlation between recurrent spontaneous abortion and chromosomal abnormalities in this study and previous studies, and also the high rate of consanguineous marriages in Ardabil province population, analysis of chromosomal abnormalities is necessary after genetic counseling for both parents with recurrent spontaneous abortions. Keywords: Recurrent Spontaneous Abortion; Chromosomal Abnormalities; Consanguineoushttp://jarums.arums.ac.ir/browse.php?a_code=A-10-607-92&slc_lang=en&sid=1Ardabil GTG- Banding Method |
| spellingShingle | Ziba Jahani Seyyed saeid Hosseini Asl Homa Akhavan Study of Chromosomal Abnormalities in Couples with Recurrent Spontaneous Abortions (RSA) in Ardabil Province Journal of Ardabil University of Medical Sciences Ardabil GTG- Banding Method |
| title | Study of Chromosomal Abnormalities in Couples with Recurrent Spontaneous Abortions (RSA) in Ardabil Province |
| title_full | Study of Chromosomal Abnormalities in Couples with Recurrent Spontaneous Abortions (RSA) in Ardabil Province |
| title_fullStr | Study of Chromosomal Abnormalities in Couples with Recurrent Spontaneous Abortions (RSA) in Ardabil Province |
| title_full_unstemmed | Study of Chromosomal Abnormalities in Couples with Recurrent Spontaneous Abortions (RSA) in Ardabil Province |
| title_short | Study of Chromosomal Abnormalities in Couples with Recurrent Spontaneous Abortions (RSA) in Ardabil Province |
| title_sort | study of chromosomal abnormalities in couples with recurrent spontaneous abortions rsa in ardabil province |
| topic | Ardabil GTG- Banding Method |
| url | http://jarums.arums.ac.ir/browse.php?a_code=A-10-607-92&slc_lang=en&sid=1 |
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