Bimodal Expression Patterns, and Not Viral Burst Sizes, Predict the Effects of Vpr on HIV-1 Proviral Populations in Jurkat Cells

Bimodal Expression Patterns, and Not Viral Burst Sizes, Predict the Effects of Vpr on HIV-1 Proviral Populations in Jurkat Cells

ABSTRACT Integration site landscapes, clonal dynamics, and latency reversal with or without vpr were compared in HIV-1-infected Jurkat cell populations, and the properties of individual clones were defined. Clones differed in fractions of long terminal repeat (LTR)-active daughter cells, with some c...

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Bibliographic Details
Main Authors: Edmond Atindaana, Abena Kissi-Twum, Sarah Emery, Cleo Burnett, Jake Pitcher, Myra Visser, Jeffrey M. Kidd, Alice Telesnitsky
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:mBio
Subjects:
HIV-1 expression properties
HIV-1 persistence
HIV-1 population dynamics
integration sites
latency reactivation
latency-reversing agents
Online Access:https://journals.asm.org/doi/10.1128/mbio.03748-21

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