Maternal folic acid supplementation and antibody persistence 5 years after hepatitis B vaccination among infants
Background: Maternal exposure to dietary factors during pregnancy may modulate the immunity of offspring by epigenetic programming. But the relationship between intrauterine environment and persistence of protective antibody after hepatitis B vaccination has not been reported. This study was to inve...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-10-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | http://dx.doi.org/10.1080/21645515.2018.1482168 |
| _version_ | 1797677472091734016 |
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| author | Xinyu Zhao Xinghuo Pang Fuzhen Wang Fuqiang Cui Li Wang Wei Zhang |
| author_facet | Xinyu Zhao Xinghuo Pang Fuzhen Wang Fuqiang Cui Li Wang Wei Zhang |
| author_sort | Xinyu Zhao |
| collection | DOAJ |
| description | Background: Maternal exposure to dietary factors during pregnancy may modulate the immunity of offspring by epigenetic programming. But the relationship between intrauterine environment and persistence of protective antibody after hepatitis B vaccination has not been reported. This study was to investigate the 5-year persistence of protective antibody response after primary hepatitis B vaccination, and its relationship with maternal folic acid supplementation. Materials and Methods: A total of 1461 children who completed a 3-dose 10 μg recombinant hepatitis B vaccine at birth and did not infect hepatitis B virus were followed up. Logistic regression and mediation analysis was used to explore the relationship between 5-year persistence of protective antibody and maternal nutrition. Results: Of 1403 children who did not revaccinated during the follow-up, 76.1% had protective hepatitis B surface antibody (anti-HBs) levels. Twenty percent of mothers did not take folate during pregnancy. Mediation analysis showed a total effect of folic acid supplementation on good persistence (odds ratio: 1.10, 95% CI: 1.03-1.17, p = 0.0010), a direct effect was 1.07 (95% CI: 1.01-1.13, p = 0.0128) and an indirect effect was 1.03 (95% CI: 1.00-1.06, p = 0.0672); the proportion of good persistence mediated by primary response was 30.3%. Conclusion: This study indicated a good protective anti-HBs persistence at year 5 after 10 μg recombination hepatitis B vaccination in infants. Maternal folic acid supplementation may improve the persistence of protective antibodies through other pathways. Multi-center cohort studies should be conducted to verify this conclusion. |
| first_indexed | 2024-03-11T22:45:38Z |
| format | Article |
| id | doaj.art-4b552608f7ba46c9ac679e94be6d2822 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:45:38Z |
| publishDate | 2018-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-4b552608f7ba46c9ac679e94be6d28222023-09-22T08:38:22ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2018-10-0114102478248410.1080/21645515.2018.14821681482168Maternal folic acid supplementation and antibody persistence 5 years after hepatitis B vaccination among infantsXinyu Zhao0Xinghuo Pang1Fuzhen Wang2Fuqiang Cui3Li Wang4Wei Zhang5Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical CollegeBeijing Center for Disease Control and PreventionChinese Center for Disease Control and PreventionChinese Center for Disease Control and PreventionInstitute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical CollegeBeijing Center for Disease Control and PreventionBackground: Maternal exposure to dietary factors during pregnancy may modulate the immunity of offspring by epigenetic programming. But the relationship between intrauterine environment and persistence of protective antibody after hepatitis B vaccination has not been reported. This study was to investigate the 5-year persistence of protective antibody response after primary hepatitis B vaccination, and its relationship with maternal folic acid supplementation. Materials and Methods: A total of 1461 children who completed a 3-dose 10 μg recombinant hepatitis B vaccine at birth and did not infect hepatitis B virus were followed up. Logistic regression and mediation analysis was used to explore the relationship between 5-year persistence of protective antibody and maternal nutrition. Results: Of 1403 children who did not revaccinated during the follow-up, 76.1% had protective hepatitis B surface antibody (anti-HBs) levels. Twenty percent of mothers did not take folate during pregnancy. Mediation analysis showed a total effect of folic acid supplementation on good persistence (odds ratio: 1.10, 95% CI: 1.03-1.17, p = 0.0010), a direct effect was 1.07 (95% CI: 1.01-1.13, p = 0.0128) and an indirect effect was 1.03 (95% CI: 1.00-1.06, p = 0.0672); the proportion of good persistence mediated by primary response was 30.3%. Conclusion: This study indicated a good protective anti-HBs persistence at year 5 after 10 μg recombination hepatitis B vaccination in infants. Maternal folic acid supplementation may improve the persistence of protective antibodies through other pathways. Multi-center cohort studies should be conducted to verify this conclusion.http://dx.doi.org/10.1080/21645515.2018.1482168hepatitis b vaccinepersistenceanti-hbsfolic acid |
| spellingShingle | Xinyu Zhao Xinghuo Pang Fuzhen Wang Fuqiang Cui Li Wang Wei Zhang Maternal folic acid supplementation and antibody persistence 5 years after hepatitis B vaccination among infants Human Vaccines & Immunotherapeutics hepatitis b vaccine persistence anti-hbs folic acid |
| title | Maternal folic acid supplementation and antibody persistence 5 years after hepatitis B vaccination among infants |
| title_full | Maternal folic acid supplementation and antibody persistence 5 years after hepatitis B vaccination among infants |
| title_fullStr | Maternal folic acid supplementation and antibody persistence 5 years after hepatitis B vaccination among infants |
| title_full_unstemmed | Maternal folic acid supplementation and antibody persistence 5 years after hepatitis B vaccination among infants |
| title_short | Maternal folic acid supplementation and antibody persistence 5 years after hepatitis B vaccination among infants |
| title_sort | maternal folic acid supplementation and antibody persistence 5 years after hepatitis b vaccination among infants |
| topic | hepatitis b vaccine persistence anti-hbs folic acid |
| url | http://dx.doi.org/10.1080/21645515.2018.1482168 |
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