Profound alteration in cutaneous primary afferent activity produced by inflammatory mediators

Profound alteration in cutaneous primary afferent activity produced by inflammatory mediators

Inflammatory pain is thought to arise from increased transmission from nociceptors and recruitment of 'silent' afferents. To evaluate inflammation-induced changes, mice expressing GCaMP3 in cutaneous sensory neurons were generated and neuronal responses to mechanical stimulation in vivo be...

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Bibliographic Details
Main Authors: Kristen M Smith-Edwards, Jennifer J DeBerry, Jami L Saloman, Brian M Davis, C Jeffery Woodbury
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
pain
nociceptor
GCaMP
calcium imaging
in vivo
ex vivo
Online Access:https://elifesciences.org/articles/20527

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