The Risk of Oxygen during Cardiac Surgery (ROCS) trial: study protocol for a randomized clinical trial

The Risk of Oxygen during Cardiac Surgery (ROCS) trial: study protocol for a randomized clinical trial

Abstract Background Anesthesiologists administer excess supplemental oxygen (hyper-oxygenation) to patients during surgery to avoid hypoxia. Hyper-oxygenation, however, may increase the generation of reactive oxygen species and cause oxidative damage. In cardiac surgery, increased oxidative damage h...

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Bibliographic Details
Main Authors: Marcos G. Lopez, Mias Pretorius, Matthew S. Shotwell, Robert Deegan, Susan S. Eagle, Jeremy M. Bennett, Bantayehu Sileshi, Yafen Liang, Brian J. Gelfand, Adam J. Kingeter, Kara K. Siegrist, Frederick W. Lombard, Tiffany M. Richburg, Dane A. Fornero, Andrew D. Shaw, Antonio Hernandez, Frederic T. Billings
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Trials
Subjects:
Normoxia
Physiologic oxygenation
Hyperoxia
Hyper-oxygenation
Oxidative stress
Reactive oxygen species
Online Access:http://link.springer.com/article/10.1186/s13063-017-2021-5

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