Stem-Cell Transplantation in Adult Patients with Relapsed/Refractory Hodgkin Lymphoma
Although the majority of patients with Hodgkin lymphoma (HL) are cured with initial therapy, in 85–90% of early stage and 70–80% of advanced-stage disease cases, relapse remains a major problem. Autologous stem-cell transplantation (auto-HCT) after salvage chemotherapy is currently considered to be...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Transplantology |
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| Online Access: | https://www.mdpi.com/2673-3943/2/4/38 |
| _version_ | 1797500161685979136 |
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| author | Sonja Genadieva Stavrik Anna Sureda |
| author_facet | Sonja Genadieva Stavrik Anna Sureda |
| author_sort | Sonja Genadieva Stavrik |
| collection | DOAJ |
| description | Although the majority of patients with Hodgkin lymphoma (HL) are cured with initial therapy, in 85–90% of early stage and 70–80% of advanced-stage disease cases, relapse remains a major problem. Autologous stem-cell transplantation (auto-HCT) after salvage chemotherapy is currently considered to be the standard of care for patients who relapse after first-line chemotherapy or for whom first-line treatment fails. The curative capacity of auto-HCT has been improving with the introduction of new drug-based salvage strategies and consolidation strategies after auto-HCT. Allogeneic stem-cell transplantation (allo-HCT) represents a reasonable treatment option for young patients who relapse or progress after auto-HCT and have chemosensitive disease at the time of transplantation. Allo-HCT is a valid treatment strategy for patients with relapse/refractory HL (r/r HL) because the results have improved over time, mainly with the safe combination of allo-HCT and new drugs. Bearing in mind that outcomes after haploidentical stem-cell transplantation (haplo-HCT) are comparable with those for matched sibling donors and matched unrelated donors, haplo-HCT is now the preferred alternative donor source for patients with r/r HL without a donor or when there is urgency to find a donor if a matched related donor is not present. The development of new drugs such as anti-CD 30 monoclonal antibodies and checkpoint inhibitors (CPI) for relapsed or refractory HL has demonstrated high response rates and durable remissions, and challenged the role and timing of HCT. The treatment of patients with HL who develop disease recurrence or progression after allo-HCT remains a real challenge and an unmet need. |
| first_indexed | 2024-03-10T03:57:54Z |
| format | Article |
| id | doaj.art-4b5726170f7643ce85aeb706db92ff31 |
| institution | Directory Open Access Journal |
| issn | 2673-3943 |
| language | English |
| last_indexed | 2024-03-10T03:57:54Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Transplantology |
| spelling | doaj.art-4b5726170f7643ce85aeb706db92ff312023-11-23T10:51:23ZengMDPI AGTransplantology2673-39432021-10-012439641110.3390/transplantology2040038Stem-Cell Transplantation in Adult Patients with Relapsed/Refractory Hodgkin LymphomaSonja Genadieva Stavrik0Anna Sureda1University Hematology Clinic, Medical Faculty, University Ss Cyril and Methodius, 1000 Skopje, North MacedoniaDepartment of Hematology, Institut Catala d’Oncologia-Hospitalet (IDIBELL), Universitat de Barcelona, 08908 Barcelona, SpainAlthough the majority of patients with Hodgkin lymphoma (HL) are cured with initial therapy, in 85–90% of early stage and 70–80% of advanced-stage disease cases, relapse remains a major problem. Autologous stem-cell transplantation (auto-HCT) after salvage chemotherapy is currently considered to be the standard of care for patients who relapse after first-line chemotherapy or for whom first-line treatment fails. The curative capacity of auto-HCT has been improving with the introduction of new drug-based salvage strategies and consolidation strategies after auto-HCT. Allogeneic stem-cell transplantation (allo-HCT) represents a reasonable treatment option for young patients who relapse or progress after auto-HCT and have chemosensitive disease at the time of transplantation. Allo-HCT is a valid treatment strategy for patients with relapse/refractory HL (r/r HL) because the results have improved over time, mainly with the safe combination of allo-HCT and new drugs. Bearing in mind that outcomes after haploidentical stem-cell transplantation (haplo-HCT) are comparable with those for matched sibling donors and matched unrelated donors, haplo-HCT is now the preferred alternative donor source for patients with r/r HL without a donor or when there is urgency to find a donor if a matched related donor is not present. The development of new drugs such as anti-CD 30 monoclonal antibodies and checkpoint inhibitors (CPI) for relapsed or refractory HL has demonstrated high response rates and durable remissions, and challenged the role and timing of HCT. The treatment of patients with HL who develop disease recurrence or progression after allo-HCT remains a real challenge and an unmet need.https://www.mdpi.com/2673-3943/2/4/38relapsed/refractory Hodgkin lymphomaautologous stem-cell transplantationallogeneic stem-cell transplantationhaploidentical stem-cell transplantation |
| spellingShingle | Sonja Genadieva Stavrik Anna Sureda Stem-Cell Transplantation in Adult Patients with Relapsed/Refractory Hodgkin Lymphoma Transplantology relapsed/refractory Hodgkin lymphoma autologous stem-cell transplantation allogeneic stem-cell transplantation haploidentical stem-cell transplantation |
| title | Stem-Cell Transplantation in Adult Patients with Relapsed/Refractory Hodgkin Lymphoma |
| title_full | Stem-Cell Transplantation in Adult Patients with Relapsed/Refractory Hodgkin Lymphoma |
| title_fullStr | Stem-Cell Transplantation in Adult Patients with Relapsed/Refractory Hodgkin Lymphoma |
| title_full_unstemmed | Stem-Cell Transplantation in Adult Patients with Relapsed/Refractory Hodgkin Lymphoma |
| title_short | Stem-Cell Transplantation in Adult Patients with Relapsed/Refractory Hodgkin Lymphoma |
| title_sort | stem cell transplantation in adult patients with relapsed refractory hodgkin lymphoma |
| topic | relapsed/refractory Hodgkin lymphoma autologous stem-cell transplantation allogeneic stem-cell transplantation haploidentical stem-cell transplantation |
| url | https://www.mdpi.com/2673-3943/2/4/38 |
| work_keys_str_mv | AT sonjagenadievastavrik stemcelltransplantationinadultpatientswithrelapsedrefractoryhodgkinlymphoma AT annasureda stemcelltransplantationinadultpatientswithrelapsedrefractoryhodgkinlymphoma |