Vitamin D Status and SARS-CoV-2 Infection in a Cohort of Kidney Transplanted Patients
Background: Recently the protective role of 25-hydroxyvitamin D (25(OH)D) against viral infections has been hypothesized. We evaluated the association between vitamin D status and SARS-CoV-2 infection susceptibility and severity in a cohort of kidney transplanted patients (KTxp). Methods: A total of...
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MDPI AG
2022-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/2/317 |
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| author | Anna Regalia Matteo Benedetti Silvia Malvica Carlo Alfieri Mariarosaria Campise Donata Cresseri Maria Teresa Gandolfo Federica Tripodi Giuseppe Castellano Piergiorgio Messa |
| author_facet | Anna Regalia Matteo Benedetti Silvia Malvica Carlo Alfieri Mariarosaria Campise Donata Cresseri Maria Teresa Gandolfo Federica Tripodi Giuseppe Castellano Piergiorgio Messa |
| author_sort | Anna Regalia |
| collection | DOAJ |
| description | Background: Recently the protective role of 25-hydroxyvitamin D (25(OH)D) against viral infections has been hypothesized. We evaluated the association between vitamin D status and SARS-CoV-2 infection susceptibility and severity in a cohort of kidney transplanted patients (KTxp). Methods: A total of 61 KTxp with SARS-CoV-2 infection (COV+) were matched with 122 healthy KTxp controls (COV−). Main biochemical parameters at 1, 6, and 12 months before SARS-CoV-2 infection were recorded. Vitamin D status was considered as the mean of two 25(OH)D measures obtained 6 ± 2 months apart during the last year. The severity of SARS-CoV-2 infection was based on the need for hospitalization (HOSP+) and death (D+). Results: 25(OH)D levels were lower in COV+ than in controls [19(12–26) vs. 23(17–31) ng/mL, <i>p</i> = 0.01]. No differences among the other biochemical parameters were found. The SARS-CoV-2 infection discriminative power of 25(OH)D was evaluated by ROC-curve (AUC 0.61, 95% CI 0.5–0.7, <i>p</i> = 0.01). 25(OH)D was not significantly different between HOSP+ and HOSP− [17(8–25) vs. 20(15–26) ng/mL, <i>p</i> = 0.19] and between D+ and D− [14(6–23) vs. 20(14–26) ng/mL, <i>p</i> = 0.22] and had no significant correlation with disease length. Conclusions: During the year preceding the infection, 25(OH)D levels were lower in COV+ KTxp in comparison with controls matched for demographic features and comorbidities. No significant association between vitamin D status and SARS-CoV-2 infection related outcomes was found. |
| first_indexed | 2024-03-10T00:46:57Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T00:46:57Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
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| series | Nutrients |
| spelling | doaj.art-4b577de64a074264889448ce039a78d52023-11-23T14:57:29ZengMDPI AGNutrients2072-66432022-01-0114231710.3390/nu14020317Vitamin D Status and SARS-CoV-2 Infection in a Cohort of Kidney Transplanted PatientsAnna Regalia0Matteo Benedetti1Silvia Malvica2Carlo Alfieri3Mariarosaria Campise4Donata Cresseri5Maria Teresa Gandolfo6Federica Tripodi7Giuseppe Castellano8Piergiorgio Messa9Department of Nephrology, Dialysis, and Renal Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Nephrology, Dialysis, and Renal Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Nephrology, Dialysis, and Renal Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Nephrology, Dialysis, and Renal Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Nephrology, Dialysis, and Renal Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Nephrology, Dialysis, and Renal Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Nephrology, Dialysis, and Renal Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Nephrology, Dialysis, and Renal Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Nephrology, Dialysis, and Renal Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Nephrology, Dialysis, and Renal Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyBackground: Recently the protective role of 25-hydroxyvitamin D (25(OH)D) against viral infections has been hypothesized. We evaluated the association between vitamin D status and SARS-CoV-2 infection susceptibility and severity in a cohort of kidney transplanted patients (KTxp). Methods: A total of 61 KTxp with SARS-CoV-2 infection (COV+) were matched with 122 healthy KTxp controls (COV−). Main biochemical parameters at 1, 6, and 12 months before SARS-CoV-2 infection were recorded. Vitamin D status was considered as the mean of two 25(OH)D measures obtained 6 ± 2 months apart during the last year. The severity of SARS-CoV-2 infection was based on the need for hospitalization (HOSP+) and death (D+). Results: 25(OH)D levels were lower in COV+ than in controls [19(12–26) vs. 23(17–31) ng/mL, <i>p</i> = 0.01]. No differences among the other biochemical parameters were found. The SARS-CoV-2 infection discriminative power of 25(OH)D was evaluated by ROC-curve (AUC 0.61, 95% CI 0.5–0.7, <i>p</i> = 0.01). 25(OH)D was not significantly different between HOSP+ and HOSP− [17(8–25) vs. 20(15–26) ng/mL, <i>p</i> = 0.19] and between D+ and D− [14(6–23) vs. 20(14–26) ng/mL, <i>p</i> = 0.22] and had no significant correlation with disease length. Conclusions: During the year preceding the infection, 25(OH)D levels were lower in COV+ KTxp in comparison with controls matched for demographic features and comorbidities. No significant association between vitamin D status and SARS-CoV-2 infection related outcomes was found.https://www.mdpi.com/2072-6643/14/2/317vitamin DSARS-CoV-2 infectionkidney transplantation |
| spellingShingle | Anna Regalia Matteo Benedetti Silvia Malvica Carlo Alfieri Mariarosaria Campise Donata Cresseri Maria Teresa Gandolfo Federica Tripodi Giuseppe Castellano Piergiorgio Messa Vitamin D Status and SARS-CoV-2 Infection in a Cohort of Kidney Transplanted Patients Nutrients vitamin D SARS-CoV-2 infection kidney transplantation |
| title | Vitamin D Status and SARS-CoV-2 Infection in a Cohort of Kidney Transplanted Patients |
| title_full | Vitamin D Status and SARS-CoV-2 Infection in a Cohort of Kidney Transplanted Patients |
| title_fullStr | Vitamin D Status and SARS-CoV-2 Infection in a Cohort of Kidney Transplanted Patients |
| title_full_unstemmed | Vitamin D Status and SARS-CoV-2 Infection in a Cohort of Kidney Transplanted Patients |
| title_short | Vitamin D Status and SARS-CoV-2 Infection in a Cohort of Kidney Transplanted Patients |
| title_sort | vitamin d status and sars cov 2 infection in a cohort of kidney transplanted patients |
| topic | vitamin D SARS-CoV-2 infection kidney transplantation |
| url | https://www.mdpi.com/2072-6643/14/2/317 |
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