Recent advances of m6A methylation in skeletal system disease
Abstract Skeletal system disease (SSD) is defined as a class of chronic disorders of skeletal system with poor prognosis and causes heavy economic burden. m6A, methylation at the N6 position of adenosine in RNA, is a reversible and dynamic modification in posttranscriptional mRNA. Evidences suggest...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-024-04944-y |
| _version_ | 1797273381211471872 |
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| author | Jianhui Liang Qian Yi Yang Liu Jiachen Li Zecheng Yang Wei Sun Weichao Sun |
| author_facet | Jianhui Liang Qian Yi Yang Liu Jiachen Li Zecheng Yang Wei Sun Weichao Sun |
| author_sort | Jianhui Liang |
| collection | DOAJ |
| description | Abstract Skeletal system disease (SSD) is defined as a class of chronic disorders of skeletal system with poor prognosis and causes heavy economic burden. m6A, methylation at the N6 position of adenosine in RNA, is a reversible and dynamic modification in posttranscriptional mRNA. Evidences suggest that m6A modifications play a crucial role in regulating biological processes of all kinds of diseases, such as malignancy. Recently studies have revealed that as the most abundant epigentic modification, m6A is involved in the progression of SSD. However, the function of m6A modification in SSD is not fully illustrated. Therefore, make clear the relationship between m6A modification and SSD pathogenesis might provide novel sights for prevention and targeted treatment of SSD. This article will summarize the recent advances of m6A regulation in the biological processes of SSD, including osteoporosis, osteosarcoma, rheumatoid arthritis and osteoarthritis, and discuss the potential clinical value, research challenge and future prospect of m6A modification in SSD. |
| first_indexed | 2024-03-07T14:43:33Z |
| format | Article |
| id | doaj.art-4b57a45fdc054771b21ad5231c33f8c2 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-03-07T14:43:33Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-4b57a45fdc054771b21ad5231c33f8c22024-03-05T20:07:39ZengBMCJournal of Translational Medicine1479-58762024-02-0122111910.1186/s12967-024-04944-yRecent advances of m6A methylation in skeletal system diseaseJianhui Liang0Qian Yi1Yang Liu2Jiachen Li3Zecheng Yang4Wei Sun5Weichao Sun6Department of Orthopedics, Shenzhen Second People’s Hospital/First Affiliated Hospital of Shenzhen University Health Science CenterDepartment of Physiology, School of Basic Medical Science, Southwest Medical UniversityDepartment of Orthopedics, Shenzhen Second People’s Hospital/First Affiliated Hospital of Shenzhen University Health Science CenterDepartment of Orthopedics, Shenzhen Second People’s Hospital/First Affiliated Hospital of Shenzhen University Health Science CenterDepartment of Orthopedics, Shenzhen Second People’s Hospital/First Affiliated Hospital of Shenzhen University Health Science CenterDepartment of Orthopedics, Shenzhen Second People’s Hospital/First Affiliated Hospital of Shenzhen University Health Science CenterDepartment of Orthopedics, Shenzhen Second People’s Hospital/First Affiliated Hospital of Shenzhen University Health Science CenterAbstract Skeletal system disease (SSD) is defined as a class of chronic disorders of skeletal system with poor prognosis and causes heavy economic burden. m6A, methylation at the N6 position of adenosine in RNA, is a reversible and dynamic modification in posttranscriptional mRNA. Evidences suggest that m6A modifications play a crucial role in regulating biological processes of all kinds of diseases, such as malignancy. Recently studies have revealed that as the most abundant epigentic modification, m6A is involved in the progression of SSD. However, the function of m6A modification in SSD is not fully illustrated. Therefore, make clear the relationship between m6A modification and SSD pathogenesis might provide novel sights for prevention and targeted treatment of SSD. This article will summarize the recent advances of m6A regulation in the biological processes of SSD, including osteoporosis, osteosarcoma, rheumatoid arthritis and osteoarthritis, and discuss the potential clinical value, research challenge and future prospect of m6A modification in SSD.https://doi.org/10.1186/s12967-024-04944-ym6A modificationOsteosarcomaOsteoporosisRheumatoid arthritisOsteoarthritis |
| spellingShingle | Jianhui Liang Qian Yi Yang Liu Jiachen Li Zecheng Yang Wei Sun Weichao Sun Recent advances of m6A methylation in skeletal system disease Journal of Translational Medicine m6A modification Osteosarcoma Osteoporosis Rheumatoid arthritis Osteoarthritis |
| title | Recent advances of m6A methylation in skeletal system disease |
| title_full | Recent advances of m6A methylation in skeletal system disease |
| title_fullStr | Recent advances of m6A methylation in skeletal system disease |
| title_full_unstemmed | Recent advances of m6A methylation in skeletal system disease |
| title_short | Recent advances of m6A methylation in skeletal system disease |
| title_sort | recent advances of m6a methylation in skeletal system disease |
| topic | m6A modification Osteosarcoma Osteoporosis Rheumatoid arthritis Osteoarthritis |
| url | https://doi.org/10.1186/s12967-024-04944-y |
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