CD4(+) T Cell Count Progress and Influencing Factors of Recovery in AIDS Patients with Virological Failure in Sichuan Province: A Retrospective Cohort Study
Dan Yuan,* Yan Zhang,* Yiping Li, Ling Li, Hong Yang, Wei Yang, Hang Yu, Liao Feng, Shu Liang Center for AIDS/STD Control and Prevention, Sichuan Center for Disease Control and Prevention, Chengdu, People’s Republic of China*These authors contributed equally to this workCorre...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2022-12-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/cd4-t-cell-count-progress-and-influencing-factors-of-recovery-in-aids--peer-reviewed-fulltext-article-IDR |
| _version_ | 1828125326023065600 |
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| author | Yuan D Zhang Y Li Y Li L Yang H Yang W Yu H Feng L Liang S |
| author_facet | Yuan D Zhang Y Li Y Li L Yang H Yang W Yu H Feng L Liang S |
| author_sort | Yuan D |
| collection | DOAJ |
| description | Dan Yuan,* Yan Zhang,* Yiping Li, Ling Li, Hong Yang, Wei Yang, Hang Yu, Liao Feng, Shu Liang Center for AIDS/STD Control and Prevention, Sichuan Center for Disease Control and Prevention, Chengdu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shu Liang; Liao Feng, Email Liangshu523@163.com; 58539976@qq.comBackground: Choosing patients with HIV/AIDS (PLWH) with virologic failure observed in the course of treatment, and analyzing the CD4(+) T cell count of PLWH with different subtypes of virus and the risk factors of CD4 (+) T cell count recoveryMethods: Analyze and evaluate the change of median CD4(+) T cell count of PLWH infected with different HIV-1 subtypes in Sichuan Province after treatment by rank sum test. Univariate and multivariate logistic regression models were used to analyze the risk factors on CD4(+) T cell count growth after PLWH treatment.Results: A total of 4977 cases were analysed, including CRF07_BC 2358 cases (47.38%), CRF01_AE 1507 cases (30.28%), CRF08_BC 577 cases (11.59%), CRF85_BC 303 cases (6.09%) and other subtypes 232 cases (4.66%). PLWH infected with CRF85_BC had lower median CD4(+) T cell count after treatment (p < 0.05). It was found that protective factors to increase CD4(+) T cell count (p < 0.05) including females, Yi people, married or cohabiting, educational level at primary school or above, initial and recent treatment with Tenofovir + Lamivudine + Nevirapine Wellen, the second-line regimen with lopinavir/ritonavir (LPV/r) and the treatment time is more than 24 months. However, over 50 years old, the disease course is in AIDS stage, the infection of CRF01_AE and CRF85_BC virus was the risk factor on CD4(+) T cell count increase (p < 0.05). PLWH with higher initial CD4 level had a lower ratio of CD4(+) T cell count increase (≥ 50 cells/μL) (p < 0.05).Conclusion: Age, sex, ethnicity, marriage, education, disease status, treatment protocols, treatment time, initial CD4(+) T cell count, and virus subtype are the influencing factors of PLWH CD4(+) T cell count increase. The poor recovery of CD4(+) T cell count after treatment was observed in PLWH infected with CRF85_BC virus.Keywords: HIV, AIDS, antiretroviral therapy, CD4(+) T cells count |
| first_indexed | 2024-04-11T15:19:06Z |
| format | Article |
| id | doaj.art-4b5ae58589a44d4594c0ebbd76001f8f |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-11T15:19:06Z |
| publishDate | 2022-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-4b5ae58589a44d4594c0ebbd76001f8f2022-12-22T04:16:24ZengDove Medical PressInfection and Drug Resistance1178-69732022-12-01Volume 156985699980026CD4(+) T Cell Count Progress and Influencing Factors of Recovery in AIDS Patients with Virological Failure in Sichuan Province: A Retrospective Cohort StudyYuan DZhang YLi YLi LYang HYang WYu HFeng LLiang SDan Yuan,* Yan Zhang,* Yiping Li, Ling Li, Hong Yang, Wei Yang, Hang Yu, Liao Feng, Shu Liang Center for AIDS/STD Control and Prevention, Sichuan Center for Disease Control and Prevention, Chengdu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shu Liang; Liao Feng, Email Liangshu523@163.com; 58539976@qq.comBackground: Choosing patients with HIV/AIDS (PLWH) with virologic failure observed in the course of treatment, and analyzing the CD4(+) T cell count of PLWH with different subtypes of virus and the risk factors of CD4 (+) T cell count recoveryMethods: Analyze and evaluate the change of median CD4(+) T cell count of PLWH infected with different HIV-1 subtypes in Sichuan Province after treatment by rank sum test. Univariate and multivariate logistic regression models were used to analyze the risk factors on CD4(+) T cell count growth after PLWH treatment.Results: A total of 4977 cases were analysed, including CRF07_BC 2358 cases (47.38%), CRF01_AE 1507 cases (30.28%), CRF08_BC 577 cases (11.59%), CRF85_BC 303 cases (6.09%) and other subtypes 232 cases (4.66%). PLWH infected with CRF85_BC had lower median CD4(+) T cell count after treatment (p < 0.05). It was found that protective factors to increase CD4(+) T cell count (p < 0.05) including females, Yi people, married or cohabiting, educational level at primary school or above, initial and recent treatment with Tenofovir + Lamivudine + Nevirapine Wellen, the second-line regimen with lopinavir/ritonavir (LPV/r) and the treatment time is more than 24 months. However, over 50 years old, the disease course is in AIDS stage, the infection of CRF01_AE and CRF85_BC virus was the risk factor on CD4(+) T cell count increase (p < 0.05). PLWH with higher initial CD4 level had a lower ratio of CD4(+) T cell count increase (≥ 50 cells/μL) (p < 0.05).Conclusion: Age, sex, ethnicity, marriage, education, disease status, treatment protocols, treatment time, initial CD4(+) T cell count, and virus subtype are the influencing factors of PLWH CD4(+) T cell count increase. The poor recovery of CD4(+) T cell count after treatment was observed in PLWH infected with CRF85_BC virus.Keywords: HIV, AIDS, antiretroviral therapy, CD4(+) T cells counthttps://www.dovepress.com/cd4-t-cell-count-progress-and-influencing-factors-of-recovery-in-aids--peer-reviewed-fulltext-article-IDRhivaidsantiretroviral therapycd4(+) t cells count; |
| spellingShingle | Yuan D Zhang Y Li Y Li L Yang H Yang W Yu H Feng L Liang S CD4(+) T Cell Count Progress and Influencing Factors of Recovery in AIDS Patients with Virological Failure in Sichuan Province: A Retrospective Cohort Study Infection and Drug Resistance hiv aids antiretroviral therapy cd4(+) t cells count; |
| title | CD4(+) T Cell Count Progress and Influencing Factors of Recovery in AIDS Patients with Virological Failure in Sichuan Province: A Retrospective Cohort Study |
| title_full | CD4(+) T Cell Count Progress and Influencing Factors of Recovery in AIDS Patients with Virological Failure in Sichuan Province: A Retrospective Cohort Study |
| title_fullStr | CD4(+) T Cell Count Progress and Influencing Factors of Recovery in AIDS Patients with Virological Failure in Sichuan Province: A Retrospective Cohort Study |
| title_full_unstemmed | CD4(+) T Cell Count Progress and Influencing Factors of Recovery in AIDS Patients with Virological Failure in Sichuan Province: A Retrospective Cohort Study |
| title_short | CD4(+) T Cell Count Progress and Influencing Factors of Recovery in AIDS Patients with Virological Failure in Sichuan Province: A Retrospective Cohort Study |
| title_sort | cd4 t cell count progress and influencing factors of recovery in aids patients with virological failure in sichuan province a retrospective cohort study |
| topic | hiv aids antiretroviral therapy cd4(+) t cells count; |
| url | https://www.dovepress.com/cd4-t-cell-count-progress-and-influencing-factors-of-recovery-in-aids--peer-reviewed-fulltext-article-IDR |
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