Vascular Endothelial Growth Factor: A Translational View in Oral Non-Communicable Diseases
Vascular endothelial growth factors (VEGFs) are vital regulators of angiogenesis that are expressed in response to soluble mediators, such as cytokines and growth factors. Their physiologic functions include blood vessel formation, regulation of vascular permeability, stem cell and monocyte/macropha...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/1/85 |
| _version_ | 1797412694604644352 |
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| author | Sven Niklander María José Bordagaray Alejandra Fernández Marcela Hernández |
| author_facet | Sven Niklander María José Bordagaray Alejandra Fernández Marcela Hernández |
| author_sort | Sven Niklander |
| collection | DOAJ |
| description | Vascular endothelial growth factors (VEGFs) are vital regulators of angiogenesis that are expressed in response to soluble mediators, such as cytokines and growth factors. Their physiologic functions include blood vessel formation, regulation of vascular permeability, stem cell and monocyte/macrophage recruitment and maintenance of bone homeostasis and repair. In addition, angiogenesis plays a pivotal role in chronic pathologic conditions, such as tumorigenesis, inflammatory immune diseases and bone loss. According to their prevalence, morbidity and mortality, inflammatory diseases affecting periodontal tissues and oral cancer are relevant non-communicable diseases. Whereas oral squamous cell carcinoma (OSCC) is considered one of the most common cancers worldwide, destructive inflammatory periodontal diseases, on the other hand, are amongst the most prevalent chronic inflammatory conditions affecting humans and also represent the main cause of tooth loss in adults. In the recent years, while knowledge regarding the role of VEGF signaling in common oral diseases is expanding, new potential translational applications emerge. In the present narrative review we aim to explore the role of VEGF signaling in oral cancer and destructive periodontal inflammatory diseases, with emphasis in its translational applications as potential biomarkers and therapeutic targets. |
| first_indexed | 2024-03-09T05:06:53Z |
| format | Article |
| id | doaj.art-4b5cf97c78d14e3ebbb4e6e0f08495ba |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T05:06:53Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-4b5cf97c78d14e3ebbb4e6e0f08495ba2023-12-03T12:54:00ZengMDPI AGBiomolecules2218-273X2021-01-011118510.3390/biom11010085Vascular Endothelial Growth Factor: A Translational View in Oral Non-Communicable DiseasesSven Niklander0María José Bordagaray1Alejandra Fernández2Marcela Hernández3Unit of Oral Pathology and Medicine, Faculty of Dentistry, Universidad Andres Bello, Viña del Mar 2520000, ChileLaboratory of Periodontal Biology, Faculty of Dentistry, Universidad de Chile, Santiago 8380544, ChileLaboratory of Periodontal Biology, Faculty of Dentistry, Universidad de Chile, Santiago 8380544, ChileLaboratory of Periodontal Biology, Faculty of Dentistry, Universidad de Chile, Santiago 8380544, ChileVascular endothelial growth factors (VEGFs) are vital regulators of angiogenesis that are expressed in response to soluble mediators, such as cytokines and growth factors. Their physiologic functions include blood vessel formation, regulation of vascular permeability, stem cell and monocyte/macrophage recruitment and maintenance of bone homeostasis and repair. In addition, angiogenesis plays a pivotal role in chronic pathologic conditions, such as tumorigenesis, inflammatory immune diseases and bone loss. According to their prevalence, morbidity and mortality, inflammatory diseases affecting periodontal tissues and oral cancer are relevant non-communicable diseases. Whereas oral squamous cell carcinoma (OSCC) is considered one of the most common cancers worldwide, destructive inflammatory periodontal diseases, on the other hand, are amongst the most prevalent chronic inflammatory conditions affecting humans and also represent the main cause of tooth loss in adults. In the recent years, while knowledge regarding the role of VEGF signaling in common oral diseases is expanding, new potential translational applications emerge. In the present narrative review we aim to explore the role of VEGF signaling in oral cancer and destructive periodontal inflammatory diseases, with emphasis in its translational applications as potential biomarkers and therapeutic targets.https://www.mdpi.com/2218-273X/11/1/85VEGFVEGFRangiogenesisperiodontitisperiimplantitisapical periodontitis |
| spellingShingle | Sven Niklander María José Bordagaray Alejandra Fernández Marcela Hernández Vascular Endothelial Growth Factor: A Translational View in Oral Non-Communicable Diseases Biomolecules VEGF VEGFR angiogenesis periodontitis periimplantitis apical periodontitis |
| title | Vascular Endothelial Growth Factor: A Translational View in Oral Non-Communicable Diseases |
| title_full | Vascular Endothelial Growth Factor: A Translational View in Oral Non-Communicable Diseases |
| title_fullStr | Vascular Endothelial Growth Factor: A Translational View in Oral Non-Communicable Diseases |
| title_full_unstemmed | Vascular Endothelial Growth Factor: A Translational View in Oral Non-Communicable Diseases |
| title_short | Vascular Endothelial Growth Factor: A Translational View in Oral Non-Communicable Diseases |
| title_sort | vascular endothelial growth factor a translational view in oral non communicable diseases |
| topic | VEGF VEGFR angiogenesis periodontitis periimplantitis apical periodontitis |
| url | https://www.mdpi.com/2218-273X/11/1/85 |
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