| Summary: | The investigation into promising botanical materials for natural cosmetics is expanding due to environmental and health awareness. Here, we aimed to evaluate the phytochemical substances and the potential skin-related pharmacological activities of four <i>Mucuna</i> seeds, namely <i>M. gigantea</i> (Willd.) DC. (MGG), <i>M. interrupta</i> Gagnep. (MIT), <i>M. monosperma</i> Wight (MMM), and <i>M. pruriens</i> (L.) DC. (MPR), belonging to the Fabaceae family. In methodology, the <i>Mucuna</i> seeds were authenticated using morphological and molecular approaches. L-DOPA, phenolics, and flavonoid content, incorporated with HPLC and GC–MS fingerprinting analyses, were determined. Then, skin-related antimicrobial, antioxidant, and antiaging activities were determined. The results revealed that MPR showed the highest L-DOPA content (75.94 mg/100 mg extract), whereas MGG exhibited the highest phenolic and flavonoid content (56.73 ± 0.62 mg gallic/g extract and 1030.11 ± 3.97 mg quercetin/g extract, respectively). Only MMM and MPR could inhibit all of <i>S. aureus</i>, <i>S. epidermidis</i>, and <i>C. albicans</i>, but no sample could inhibit <i>C. acnes</i>. Furthermore, all samples demonstrated antioxidant activity. Interestingly, all <i>Mucuna</i> samples exhibited strong collagenase, elastase, and hyaluronidase inhibitory activities. We conclude that the ethanolic extracts of four <i>Mucuna</i> seeds are probably advantageous in the development of skincare cosmeceutical products.
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