High Morphine Use Disorder Susceptibility Is Predicted by Impaired Learning Ability in Mice
An obvious reason for substance uses disorders (SUDs) is drug craving and seeking behavior induced by conditioned context, which is an abnormal solid context memory. The relationship between susceptibility to SUD and learning ability remains unclear in humans and animal models. In this study, we fou...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/12/1650 |
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| author | Xue-Fei Hou Ya-Bo Zhao Yue-Xiong Yang Chen Ma Meng Li Xin Li Guo-Rui Ma Li-Su Zhu Lin Xu Qi-Xin Zhou |
| author_facet | Xue-Fei Hou Ya-Bo Zhao Yue-Xiong Yang Chen Ma Meng Li Xin Li Guo-Rui Ma Li-Su Zhu Lin Xu Qi-Xin Zhou |
| author_sort | Xue-Fei Hou |
| collection | DOAJ |
| description | An obvious reason for substance uses disorders (SUDs) is drug craving and seeking behavior induced by conditioned context, which is an abnormal solid context memory. The relationship between susceptibility to SUD and learning ability remains unclear in humans and animal models. In this study, we found that susceptibility to morphine use disorder (MUD) was negatively correlated with learning ability in conditioned place preference (CPP) in C57 mice. By using behavioral tests, we identified the FVB mouse as learning impaired. In addition, we discovered that learning-relevant proteins, such as the glutamate receptor subunits GluA1, NR1, and NR2A, were decreased in FVB mice. Finally, we assessed the context learning ability of FVB mice using the CPP test and priming. We found that FVB mice had lower learning performance with respect to normal memory but higher performance of morphine-reinstatement memory. Compared to C57 mice, FVB mice are highly sensitive to MUDs. Our results suggest that SUD susceptibility is predicted by impaired learning ability in mice; therefore, learning ability can play a simple and practical role in identifying high-risk SUD groups. |
| first_indexed | 2024-03-09T17:15:08Z |
| format | Article |
| id | doaj.art-4b606eb90382492e930ed9339219a618 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T17:15:08Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-4b606eb90382492e930ed9339219a6182023-11-24T13:39:22ZengMDPI AGBrain Sciences2076-34252022-12-011212165010.3390/brainsci12121650High Morphine Use Disorder Susceptibility Is Predicted by Impaired Learning Ability in MiceXue-Fei Hou0Ya-Bo Zhao1Yue-Xiong Yang2Chen Ma3Meng Li4Xin Li5Guo-Rui Ma6Li-Su Zhu7Lin Xu8Qi-Xin Zhou9School of Life Sciences, Yunnan University, Kunming 650504, ChinaLaboratory of Learning and Memory, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Kunming 650223, ChinaLaboratory of Learning and Memory, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Kunming 650223, ChinaLaboratory of Learning and Memory, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Kunming 650223, ChinaLaboratory of Learning and Memory, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Kunming 650223, ChinaBiomedical Engineering Research Center, Kunming Medical University, Kunming 650500, ChinaBiomedical Engineering Research Center, Kunming Medical University, Kunming 650500, ChinaBiomedical Engineering Research Center, Kunming Medical University, Kunming 650500, ChinaSchool of Life Sciences, Yunnan University, Kunming 650504, ChinaLaboratory of Learning and Memory, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Kunming 650223, ChinaAn obvious reason for substance uses disorders (SUDs) is drug craving and seeking behavior induced by conditioned context, which is an abnormal solid context memory. The relationship between susceptibility to SUD and learning ability remains unclear in humans and animal models. In this study, we found that susceptibility to morphine use disorder (MUD) was negatively correlated with learning ability in conditioned place preference (CPP) in C57 mice. By using behavioral tests, we identified the FVB mouse as learning impaired. In addition, we discovered that learning-relevant proteins, such as the glutamate receptor subunits GluA1, NR1, and NR2A, were decreased in FVB mice. Finally, we assessed the context learning ability of FVB mice using the CPP test and priming. We found that FVB mice had lower learning performance with respect to normal memory but higher performance of morphine-reinstatement memory. Compared to C57 mice, FVB mice are highly sensitive to MUDs. Our results suggest that SUD susceptibility is predicted by impaired learning ability in mice; therefore, learning ability can play a simple and practical role in identifying high-risk SUD groups.https://www.mdpi.com/2076-3425/12/12/1650substance uses disordersmorphinelearning abilityFVB mice |
| spellingShingle | Xue-Fei Hou Ya-Bo Zhao Yue-Xiong Yang Chen Ma Meng Li Xin Li Guo-Rui Ma Li-Su Zhu Lin Xu Qi-Xin Zhou High Morphine Use Disorder Susceptibility Is Predicted by Impaired Learning Ability in Mice Brain Sciences substance uses disorders morphine learning ability FVB mice |
| title | High Morphine Use Disorder Susceptibility Is Predicted by Impaired Learning Ability in Mice |
| title_full | High Morphine Use Disorder Susceptibility Is Predicted by Impaired Learning Ability in Mice |
| title_fullStr | High Morphine Use Disorder Susceptibility Is Predicted by Impaired Learning Ability in Mice |
| title_full_unstemmed | High Morphine Use Disorder Susceptibility Is Predicted by Impaired Learning Ability in Mice |
| title_short | High Morphine Use Disorder Susceptibility Is Predicted by Impaired Learning Ability in Mice |
| title_sort | high morphine use disorder susceptibility is predicted by impaired learning ability in mice |
| topic | substance uses disorders morphine learning ability FVB mice |
| url | https://www.mdpi.com/2076-3425/12/12/1650 |
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