Stabilization of Tc-99m radiopharmaceuticals by chemical additives (NOTE)
The reliability and applicability of the preparation of the three, for nuclear medicine very important, 99mTc-radiopharmaceuticals from the inactive (technetium-cold) kit solutions were tested. Each examined commercial kit was dissolved in saline (0.9 % NaCl). The conditions of the storage of the in...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2001-09-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.shd.org.yu/HtDocs/SHD/Vol66/No9/V66-No9-03.pdf |
| _version_ | 1818515124956168192 |
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| author | NADEZDA VUKICEVIC JURIJ VUCINA |
| author_facet | NADEZDA VUKICEVIC JURIJ VUCINA |
| author_sort | NADEZDA VUKICEVIC |
| collection | DOAJ |
| description | The reliability and applicability of the preparation of the three, for nuclear medicine very important, 99mTc-radiopharmaceuticals from the inactive (technetium-cold) kit solutions were tested. Each examined commercial kit was dissolved in saline (0.9 % NaCl). The conditions of the storage of the inactive kit solutions till labeling were examined. The main problem is the stablity of the reductant stannous ions which is very difficult to predict. To stabilize and ensure a good quality of the labeled radiopharmaceuticals, ascorbic or gentisic acid were added. It was found that the best results were obtained by keeping the samples frozen at 20 ?C. Both stabilizers can be used but for an effective protection much lower concentrations of ascorbic acid are needed. Its concentrations of 1260 mg/ml of the kit, stabilized dimercaptosuccinate (DMS) and pyrophosphate (PyP) for about 78 days. The solution of 2,3-dicarboxypropane-1,1-diphosphonate (DPD) was found to be stable even without the stabilizer. This could be attributed probably to the chemical nature of this complex. However, in routine praxis the applied procedure demands great care and personel very experienced in radiopharmacy. |
| first_indexed | 2024-12-11T00:24:53Z |
| format | Article |
| id | doaj.art-4b62aab3cba34715b4248777fc55f4fa |
| institution | Directory Open Access Journal |
| issn | 0352-5139 |
| language | English |
| last_indexed | 2024-12-11T00:24:53Z |
| publishDate | 2001-09-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-4b62aab3cba34715b4248777fc55f4fa2022-12-22T01:27:35ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51392001-09-01669591596Stabilization of Tc-99m radiopharmaceuticals by chemical additives (NOTE)NADEZDA VUKICEVICJURIJ VUCINAThe reliability and applicability of the preparation of the three, for nuclear medicine very important, 99mTc-radiopharmaceuticals from the inactive (technetium-cold) kit solutions were tested. Each examined commercial kit was dissolved in saline (0.9 % NaCl). The conditions of the storage of the inactive kit solutions till labeling were examined. The main problem is the stablity of the reductant stannous ions which is very difficult to predict. To stabilize and ensure a good quality of the labeled radiopharmaceuticals, ascorbic or gentisic acid were added. It was found that the best results were obtained by keeping the samples frozen at 20 ?C. Both stabilizers can be used but for an effective protection much lower concentrations of ascorbic acid are needed. Its concentrations of 1260 mg/ml of the kit, stabilized dimercaptosuccinate (DMS) and pyrophosphate (PyP) for about 78 days. The solution of 2,3-dicarboxypropane-1,1-diphosphonate (DPD) was found to be stable even without the stabilizer. This could be attributed probably to the chemical nature of this complex. However, in routine praxis the applied procedure demands great care and personel very experienced in radiopharmacy.http://www.shd.org.yu/HtDocs/SHD/Vol66/No9/V66-No9-03.pdfRadiopharmaceuticalstechnetium-99mdimercaptosuccinatedicarboxypropane diphosphonatepyrophosphate |
| spellingShingle | NADEZDA VUKICEVIC JURIJ VUCINA Stabilization of Tc-99m radiopharmaceuticals by chemical additives (NOTE) Journal of the Serbian Chemical Society Radiopharmaceuticals technetium-99m dimercaptosuccinate dicarboxypropane diphosphonate pyrophosphate |
| title | Stabilization of Tc-99m radiopharmaceuticals by chemical additives (NOTE) |
| title_full | Stabilization of Tc-99m radiopharmaceuticals by chemical additives (NOTE) |
| title_fullStr | Stabilization of Tc-99m radiopharmaceuticals by chemical additives (NOTE) |
| title_full_unstemmed | Stabilization of Tc-99m radiopharmaceuticals by chemical additives (NOTE) |
| title_short | Stabilization of Tc-99m radiopharmaceuticals by chemical additives (NOTE) |
| title_sort | stabilization of tc 99m radiopharmaceuticals by chemical additives note |
| topic | Radiopharmaceuticals technetium-99m dimercaptosuccinate dicarboxypropane diphosphonate pyrophosphate |
| url | http://www.shd.org.yu/HtDocs/SHD/Vol66/No9/V66-No9-03.pdf |
| work_keys_str_mv | AT nadezdavukicevic stabilizationoftc99mradiopharmaceuticalsbychemicaladditivesnote AT jurijvucina stabilizationoftc99mradiopharmaceuticalsbychemicaladditivesnote |