The causal relationship between gut microbiota and inflammatory dermatoses: a Mendelian randomization study
BackgroundObservational studies have shown that gut microbiota is closely associated with inflammatory dermatoses such as psoriasis, rosacea, and atopic dermatitis (AD). However, the causal relationship between gut microbiota and inflammatory dermatosis remains unclear.MethodsBased on Maximum Likeli...
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| Format: | Article |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1231848/full |
| _version_ | 1827805032909635584 |
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| author | Rui Mao Rui Mao Rui Mao Qinyang Yu Qinyang Yu Qinyang Yu Ji Li Ji Li Ji Li |
| author_facet | Rui Mao Rui Mao Rui Mao Qinyang Yu Qinyang Yu Qinyang Yu Ji Li Ji Li Ji Li |
| author_sort | Rui Mao |
| collection | DOAJ |
| description | BackgroundObservational studies have shown that gut microbiota is closely associated with inflammatory dermatoses such as psoriasis, rosacea, and atopic dermatitis (AD). However, the causal relationship between gut microbiota and inflammatory dermatosis remains unclear.MethodsBased on Maximum Likelihood (ML), MR-Egger regression, Inverse Variance Weighted (IVW), MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO), Weighted Mode, and Weighted Median Estimator (WME) methods, we performed a bidirectional two-sample Mendelian randomization (MR) analysis to explore the causal relationship between gut microbiota and inflammatory dermatosis. The genome-wide association study (GWAS) summary data of gut microbiota came from the MiBioGen consortium, while the GWAS summary data of inflammatory dermatosis (including psoriasis, AD, rosacea, vitiligo, acne, and eczema) came from the FinnGen consortium and IEU Open GWAS project. Cochran’s IVW Q test tested the heterogeneity among instrumental variables (IVs). The horizontal pleiotropy was tested by MR-Egger regression intercept analysis and MR-PRESSO analysis.ResultsEventually, the results indicated that 5, 16, 17, 11, 15, and 12 gut microbiota had significant causal effects on psoriasis, rosacea, AD, vitiligo, acne, and eczema, respectively, including 42 protective and 34 risk causal relationships. Especially, Lactobacilli and Bifidobacteria at the Family and Genus Level, as common probiotics, were identified as protective factors for the corresponding inflammatory dermatoses. The results of reverse MR analysis suggested a bidirectional causal effect between AD and genus Eubacterium brachy group, vitiligo and genus Ruminococcaceae UCG004. The causal relationship between gut microbiota and psoriasis, rosacea, acne, and eczema is unidirectional. There was no significant heterogeneity among these IVs. In conclusion, this bidirectional two-sample MR study identified 76 causal relationships between the gut microbiome and six inflammatory dermatoses, which may be helpful for the clinical prevention and treatment of inflammatory dermatoses. |
| first_indexed | 2024-03-11T21:19:49Z |
| format | Article |
| id | doaj.art-4b63864555794c28ba8bc8d25cd83dcf |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T21:19:49Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj.art-4b63864555794c28ba8bc8d25cd83dcf2023-09-28T09:26:28ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-09-011410.3389/fimmu.2023.12318481231848The causal relationship between gut microbiota and inflammatory dermatoses: a Mendelian randomization studyRui Mao0Rui Mao1Rui Mao2Qinyang Yu3Qinyang Yu4Qinyang Yu5Ji Li6Ji Li7Ji Li8Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaHunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaHunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaHunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaBackgroundObservational studies have shown that gut microbiota is closely associated with inflammatory dermatoses such as psoriasis, rosacea, and atopic dermatitis (AD). However, the causal relationship between gut microbiota and inflammatory dermatosis remains unclear.MethodsBased on Maximum Likelihood (ML), MR-Egger regression, Inverse Variance Weighted (IVW), MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO), Weighted Mode, and Weighted Median Estimator (WME) methods, we performed a bidirectional two-sample Mendelian randomization (MR) analysis to explore the causal relationship between gut microbiota and inflammatory dermatosis. The genome-wide association study (GWAS) summary data of gut microbiota came from the MiBioGen consortium, while the GWAS summary data of inflammatory dermatosis (including psoriasis, AD, rosacea, vitiligo, acne, and eczema) came from the FinnGen consortium and IEU Open GWAS project. Cochran’s IVW Q test tested the heterogeneity among instrumental variables (IVs). The horizontal pleiotropy was tested by MR-Egger regression intercept analysis and MR-PRESSO analysis.ResultsEventually, the results indicated that 5, 16, 17, 11, 15, and 12 gut microbiota had significant causal effects on psoriasis, rosacea, AD, vitiligo, acne, and eczema, respectively, including 42 protective and 34 risk causal relationships. Especially, Lactobacilli and Bifidobacteria at the Family and Genus Level, as common probiotics, were identified as protective factors for the corresponding inflammatory dermatoses. The results of reverse MR analysis suggested a bidirectional causal effect between AD and genus Eubacterium brachy group, vitiligo and genus Ruminococcaceae UCG004. The causal relationship between gut microbiota and psoriasis, rosacea, acne, and eczema is unidirectional. There was no significant heterogeneity among these IVs. In conclusion, this bidirectional two-sample MR study identified 76 causal relationships between the gut microbiome and six inflammatory dermatoses, which may be helpful for the clinical prevention and treatment of inflammatory dermatoses.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1231848/fullgut microbiotatwo-sample mendelian randomizationpsoriasisrosaceaatopic dermatitisvitiligo |
| spellingShingle | Rui Mao Rui Mao Rui Mao Qinyang Yu Qinyang Yu Qinyang Yu Ji Li Ji Li Ji Li The causal relationship between gut microbiota and inflammatory dermatoses: a Mendelian randomization study Frontiers in Immunology gut microbiota two-sample mendelian randomization psoriasis rosacea atopic dermatitis vitiligo |
| title | The causal relationship between gut microbiota and inflammatory dermatoses: a Mendelian randomization study |
| title_full | The causal relationship between gut microbiota and inflammatory dermatoses: a Mendelian randomization study |
| title_fullStr | The causal relationship between gut microbiota and inflammatory dermatoses: a Mendelian randomization study |
| title_full_unstemmed | The causal relationship between gut microbiota and inflammatory dermatoses: a Mendelian randomization study |
| title_short | The causal relationship between gut microbiota and inflammatory dermatoses: a Mendelian randomization study |
| title_sort | causal relationship between gut microbiota and inflammatory dermatoses a mendelian randomization study |
| topic | gut microbiota two-sample mendelian randomization psoriasis rosacea atopic dermatitis vitiligo |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1231848/full |
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