Endurance Exercise Mitigates Immunometabolic Adipose Tissue Disturbances in Cancer and Obesity
Adipose tissue is considered an endocrine organ whose complex biology can be explained by the diversity of cell types that compose this tissue. The immune cells found in the stromal portion of adipose tissue play an important role on the modulation of inflammation by adipocytokines secretion. The in...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/24/9745 |
| _version_ | 1797543995826503680 |
|---|---|
| author | José Cesar Rosa-Neto Loreana Sanches Silveira |
| author_facet | José Cesar Rosa-Neto Loreana Sanches Silveira |
| author_sort | José Cesar Rosa-Neto |
| collection | DOAJ |
| description | Adipose tissue is considered an endocrine organ whose complex biology can be explained by the diversity of cell types that compose this tissue. The immune cells found in the stromal portion of adipose tissue play an important role on the modulation of inflammation by adipocytokines secretion. The interactions between metabolic active tissues and immune cells, called immunometabolism, is an important field for discovering new pathways and approaches to treat immunometabolic diseases, such as obesity and cancer. Moreover, physical exercise is widely known as a tool for prevention and adjuvant treatment on metabolic diseases. More specifically, aerobic exercise training is able to increase the energy expenditure, reduce the nutrition overload and modify the profile of adipocytokines and myokines with paracrine and endocrine effects. Therefore, our aim in this review was to cover the effects of aerobic exercise training on the immunometabolism of adipose tissue in obesity and cancer, focusing on the exercise-related modification on adipose tissue or immune cells isolated as well as their interaction. |
| first_indexed | 2024-03-10T13:54:08Z |
| format | Article |
| id | doaj.art-4b6468ac705b4977b8a6cfa676894339 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:54:08Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4b6468ac705b4977b8a6cfa6768943392023-11-21T01:49:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-012124974510.3390/ijms21249745Endurance Exercise Mitigates Immunometabolic Adipose Tissue Disturbances in Cancer and ObesityJosé Cesar Rosa-Neto0Loreana Sanches Silveira1Immunometabolism Research Group, Department of Systems Biology, Institute of Biomedical Sciences 1, University of São Paulo (ICB1-USP), São Paulo 05508-000, BrazilImmunometabolism Research Group, Department of Systems Biology, Institute of Biomedical Sciences 1, University of São Paulo (ICB1-USP), São Paulo 05508-000, BrazilAdipose tissue is considered an endocrine organ whose complex biology can be explained by the diversity of cell types that compose this tissue. The immune cells found in the stromal portion of adipose tissue play an important role on the modulation of inflammation by adipocytokines secretion. The interactions between metabolic active tissues and immune cells, called immunometabolism, is an important field for discovering new pathways and approaches to treat immunometabolic diseases, such as obesity and cancer. Moreover, physical exercise is widely known as a tool for prevention and adjuvant treatment on metabolic diseases. More specifically, aerobic exercise training is able to increase the energy expenditure, reduce the nutrition overload and modify the profile of adipocytokines and myokines with paracrine and endocrine effects. Therefore, our aim in this review was to cover the effects of aerobic exercise training on the immunometabolism of adipose tissue in obesity and cancer, focusing on the exercise-related modification on adipose tissue or immune cells isolated as well as their interaction.https://www.mdpi.com/1422-0067/21/24/9745physical activityimmunometabolismimmune celllow grade inflammationadipocytokines |
| spellingShingle | José Cesar Rosa-Neto Loreana Sanches Silveira Endurance Exercise Mitigates Immunometabolic Adipose Tissue Disturbances in Cancer and Obesity International Journal of Molecular Sciences physical activity immunometabolism immune cell low grade inflammation adipocytokines |
| title | Endurance Exercise Mitigates Immunometabolic Adipose Tissue Disturbances in Cancer and Obesity |
| title_full | Endurance Exercise Mitigates Immunometabolic Adipose Tissue Disturbances in Cancer and Obesity |
| title_fullStr | Endurance Exercise Mitigates Immunometabolic Adipose Tissue Disturbances in Cancer and Obesity |
| title_full_unstemmed | Endurance Exercise Mitigates Immunometabolic Adipose Tissue Disturbances in Cancer and Obesity |
| title_short | Endurance Exercise Mitigates Immunometabolic Adipose Tissue Disturbances in Cancer and Obesity |
| title_sort | endurance exercise mitigates immunometabolic adipose tissue disturbances in cancer and obesity |
| topic | physical activity immunometabolism immune cell low grade inflammation adipocytokines |
| url | https://www.mdpi.com/1422-0067/21/24/9745 |
| work_keys_str_mv | AT josecesarrosaneto enduranceexercisemitigatesimmunometabolicadiposetissuedisturbancesincancerandobesity AT loreanasanchessilveira enduranceexercisemitigatesimmunometabolicadiposetissuedisturbancesincancerandobesity |