Amphiphilic poly{[α-maleic anhydride-ω-methoxypoly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery
Jinfeng Xing, Liandong Deng, Jun Li, Anjie DongDepartment of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People’s Republic of ChinaAbstract: In this study, the transdermal drug delivery properties of D,L-tetrahydropalmati...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2009-10-01
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| Series: | International Journal of Nanomedicine |
| Online Access: | http://www.dovepress.com/amphiphilic-polyalpha-maleic-anhydride-omega-methoxypolyethylene-glyco-a3643 |
| _version_ | 1818367216256548864 |
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| author | Jinfeng Xing Liandong Deng Jun Li et al.  |
| author_facet | Jinfeng Xing Liandong Deng Jun Li et al.  |
| author_sort | Jinfeng Xing |
| collection | DOAJ |
| description | Jinfeng Xing, Liandong Deng, Jun Li, Anjie DongDepartment of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People’s Republic of ChinaAbstract: In this study, the transdermal drug delivery properties of D,L-tetrahydropalmatine (THP)-loaded amphiphilic poly{[α-maleic anhydride-ω-methoxy-poly(ethylene glycol)]-co-(ethyl cyanoacrylate)} (PEGECA) graft copolymer nanoparticles (PEGECAT NPs) were evaluated by skin penetration experiments in vitro. The transdermal permeation experiments in vitro were carried out in Franz diffusion cells using THP-loaded PEGECAT NPs as the donor system. Transmission electron microscopy and Fourier transform infrared spectroscopy were used to characterize the receptor fluid. The results indicate that the THP-loaded PEGECAT NPs are able to penetrate the rat skin. Fluorescent microscopy measurements demonstrate that THP-loaded PEGECAT NPs can penetrate the skin not only via appendage routes but also via epidermal routes. This nanotechnology has potential application in transdermal drug delivery. Keywords: poly{[α-maleic anhydride-ω-methoxy-poly(ethylene glycol)]-co-(ethyl cyanoacrylate)}, nanoparticles, transdermal drug delivery, D,L-tetrahydropalmatine |
| first_indexed | 2024-12-13T22:48:31Z |
| format | Article |
| id | doaj.art-4b64f7b18bfc490898606bc654c513f5 |
| institution | Directory Open Access Journal |
| issn | 1176-9114 1178-2013 |
| language | English |
| last_indexed | 2024-12-13T22:48:31Z |
| publishDate | 2009-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-4b64f7b18bfc490898606bc654c513f52022-12-21T23:28:40ZengDove Medical PressInternational Journal of Nanomedicine1176-91141178-20132009-10-012009default227232Amphiphilic poly{[α-maleic anhydride-ω-methoxypoly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug deliveryJinfeng XingLiandong DengJun Liet al. Jinfeng Xing, Liandong Deng, Jun Li, Anjie DongDepartment of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People’s Republic of ChinaAbstract: In this study, the transdermal drug delivery properties of D,L-tetrahydropalmatine (THP)-loaded amphiphilic poly{[α-maleic anhydride-ω-methoxy-poly(ethylene glycol)]-co-(ethyl cyanoacrylate)} (PEGECA) graft copolymer nanoparticles (PEGECAT NPs) were evaluated by skin penetration experiments in vitro. The transdermal permeation experiments in vitro were carried out in Franz diffusion cells using THP-loaded PEGECAT NPs as the donor system. Transmission electron microscopy and Fourier transform infrared spectroscopy were used to characterize the receptor fluid. The results indicate that the THP-loaded PEGECAT NPs are able to penetrate the rat skin. Fluorescent microscopy measurements demonstrate that THP-loaded PEGECAT NPs can penetrate the skin not only via appendage routes but also via epidermal routes. This nanotechnology has potential application in transdermal drug delivery. Keywords: poly{[α-maleic anhydride-ω-methoxy-poly(ethylene glycol)]-co-(ethyl cyanoacrylate)}, nanoparticles, transdermal drug delivery, D,L-tetrahydropalmatinehttp://www.dovepress.com/amphiphilic-polyalpha-maleic-anhydride-omega-methoxypolyethylene-glyco-a3643 |
| spellingShingle | Jinfeng Xing Liandong Deng Jun Li et al.  Amphiphilic poly{[α-maleic anhydride-ω-methoxypoly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery International Journal of Nanomedicine |
| title | Amphiphilic poly{[α-maleic anhydride-ω-methoxypoly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery |
| title_full | Amphiphilic poly{[α-maleic anhydride-ω-methoxypoly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery |
| title_fullStr | Amphiphilic poly{[α-maleic anhydride-ω-methoxypoly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery |
| title_full_unstemmed | Amphiphilic poly{[α-maleic anhydride-ω-methoxypoly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery |
| title_short | Amphiphilic poly{[α-maleic anhydride-ω-methoxypoly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery |
| title_sort | amphiphilic poly amp alpha maleic anhydride amp omega methoxypoly ethylene glycol co ethyl cyanoacrylate graft copolymer nanoparticles as carriers for transdermal drug delivery |
| url | http://www.dovepress.com/amphiphilic-polyalpha-maleic-anhydride-omega-methoxypolyethylene-glyco-a3643 |
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