A novel glycyrrhizin acid-coated stent reduces neointimal formation in a rabbit iliac artery model
Introduction: Most drug-eluting stents (DESs) inhibit intimal hyperplasia but impair re-endothelialization. This study aimed to evaluate in vivo strut coverage and neointimal growth in a new glycyrrhizin acid (GA)-eluting stent.Methods: New Zealand White rabbits (n = 20) with atherosclerotic plaques...
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1159779/full |
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| author | Shuai Teng Zhaowei Zhu Yang Li Xinqun Hu Zhenfei Fang Zhenjiang Liu Shenghua Zhou |
| author_facet | Shuai Teng Zhaowei Zhu Yang Li Xinqun Hu Zhenfei Fang Zhenjiang Liu Shenghua Zhou |
| author_sort | Shuai Teng |
| collection | DOAJ |
| description | Introduction: Most drug-eluting stents (DESs) inhibit intimal hyperplasia but impair re-endothelialization. This study aimed to evaluate in vivo strut coverage and neointimal growth in a new glycyrrhizin acid (GA)-eluting stent.Methods: New Zealand White rabbits (n = 20) with atherosclerotic plaques were randomly divided into three groups based on implanted iliac artery stents: bare-metal stents (BMSs), rapamycin-eluting stents, and GA-eluting stents. After the in vivo intravascular ultrasound (IVUS) assessment at 28 days, the vessels were harvested for scanning electron microscopy (SEM) and histology. After 4 weeks of follow-up, the stent and external elastic lamina (EEL) areas were compared among the groups.Results: The rapamycin- or GA-eluting stents significantly reduced the neointimal area compared with BMSs, though GA-eluting stents had the lowest reduction. There were more uncovered struts for rapamycin-eluting stents than those for GA-eluting stents and bare-metal stents. The endothelial nitric oxide synthase (eNOS) expression in GA-eluting stents was much higher than that in BMSs and rapamycin-eluting stents, even though the endothelial coverage between struts was equivalent between BMSs and GA-eluting stents. Moreover, GA-eluting stents markedly promoted re-endothelialization and improved arterial healing compared to rapamycin-eluting stents in a rabbit atherosclerotic model.Conclusion: In conclusion, the novel GA-coated stent used in this study inhibited intimal hyperplasia and promoted re-endothelialization. |
| first_indexed | 2024-03-13T10:54:14Z |
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| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-13T10:54:14Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-4b64fbc723734f5e8d2b5ac87765eb242023-05-17T05:27:12ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-05-011410.3389/fphar.2023.11597791159779A novel glycyrrhizin acid-coated stent reduces neointimal formation in a rabbit iliac artery modelShuai Teng0Zhaowei Zhu1Yang Li2Xinqun Hu3Zhenfei Fang4Zhenjiang Liu5Shenghua Zhou6Department of Cardiovascular Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Cardiovascular Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Vascular Surgery, Xiamen Cardiovascular Hospital, Xiamen University, Xiamen, Fujian, ChinaDepartment of Cardiovascular Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Cardiovascular Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Cardiovascular Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Cardiovascular Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaIntroduction: Most drug-eluting stents (DESs) inhibit intimal hyperplasia but impair re-endothelialization. This study aimed to evaluate in vivo strut coverage and neointimal growth in a new glycyrrhizin acid (GA)-eluting stent.Methods: New Zealand White rabbits (n = 20) with atherosclerotic plaques were randomly divided into three groups based on implanted iliac artery stents: bare-metal stents (BMSs), rapamycin-eluting stents, and GA-eluting stents. After the in vivo intravascular ultrasound (IVUS) assessment at 28 days, the vessels were harvested for scanning electron microscopy (SEM) and histology. After 4 weeks of follow-up, the stent and external elastic lamina (EEL) areas were compared among the groups.Results: The rapamycin- or GA-eluting stents significantly reduced the neointimal area compared with BMSs, though GA-eluting stents had the lowest reduction. There were more uncovered struts for rapamycin-eluting stents than those for GA-eluting stents and bare-metal stents. The endothelial nitric oxide synthase (eNOS) expression in GA-eluting stents was much higher than that in BMSs and rapamycin-eluting stents, even though the endothelial coverage between struts was equivalent between BMSs and GA-eluting stents. Moreover, GA-eluting stents markedly promoted re-endothelialization and improved arterial healing compared to rapamycin-eluting stents in a rabbit atherosclerotic model.Conclusion: In conclusion, the novel GA-coated stent used in this study inhibited intimal hyperplasia and promoted re-endothelialization.https://www.frontiersin.org/articles/10.3389/fphar.2023.1159779/fulldrug-eluting stentsglycyrrhizin acidintimal hyperplasiaeNOSre-endothelialization |
| spellingShingle | Shuai Teng Zhaowei Zhu Yang Li Xinqun Hu Zhenfei Fang Zhenjiang Liu Shenghua Zhou A novel glycyrrhizin acid-coated stent reduces neointimal formation in a rabbit iliac artery model Frontiers in Pharmacology drug-eluting stents glycyrrhizin acid intimal hyperplasia eNOS re-endothelialization |
| title | A novel glycyrrhizin acid-coated stent reduces neointimal formation in a rabbit iliac artery model |
| title_full | A novel glycyrrhizin acid-coated stent reduces neointimal formation in a rabbit iliac artery model |
| title_fullStr | A novel glycyrrhizin acid-coated stent reduces neointimal formation in a rabbit iliac artery model |
| title_full_unstemmed | A novel glycyrrhizin acid-coated stent reduces neointimal formation in a rabbit iliac artery model |
| title_short | A novel glycyrrhizin acid-coated stent reduces neointimal formation in a rabbit iliac artery model |
| title_sort | novel glycyrrhizin acid coated stent reduces neointimal formation in a rabbit iliac artery model |
| topic | drug-eluting stents glycyrrhizin acid intimal hyperplasia eNOS re-endothelialization |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1159779/full |
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