Rates of bleeding, thrombosis, and survival in patients who underwent hematopoietic cell transplantation at king abdulaziz medical city, Riyadh, Saudi Arabia
BACKGROUND: Bleeding tendency and thrombosis are two major hematological complications observed in patients after hematopoietic cell transplantation (HCT). Although these complications are well reported in western communities, they are not well established in Saudi Arabia. OBJECTIVES: This retrospec...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Applied Hematology |
| Subjects: | |
| Online Access: | http://www.jahjournal.org/article.asp?issn=1658-5127;year=2021;volume=12;issue=1;spage=10;epage=16;aulast=Alqahtani |
| _version_ | 1818454210721611776 |
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| author | Sultan Alqahtani Ahmed Alragea Basil Alqahtani Nawaf Alhoshan Ibrahim Aljasser Abdulaziz Alobaied Mohammed Alassiri Emad Masuadi Mohsen Alzahrani |
| author_facet | Sultan Alqahtani Ahmed Alragea Basil Alqahtani Nawaf Alhoshan Ibrahim Aljasser Abdulaziz Alobaied Mohammed Alassiri Emad Masuadi Mohsen Alzahrani |
| author_sort | Sultan Alqahtani |
| collection | DOAJ |
| description | BACKGROUND: Bleeding tendency and thrombosis are two major hematological complications observed in patients after hematopoietic cell transplantation (HCT). Although these complications are well reported in western communities, they are not well established in Saudi Arabia.
OBJECTIVES: This retrospective study investigated the rates of bleeding, thrombosis, and survival in Saudi and non-Saudi patients who underwent HCT at King Abdulaziz Medical City, Riyadh, Saudi Arabia, from 2010 to 2017.
METHODS AND MATERIALS: A total of 372 Saudi and non-Saudi patients of both sexes with leukemia, anemia disorders, lymphoma, and other types of pathological disorders who underwent autologous or allogeneic HCT were included in this study. Patient data including age, sex, nationality, type of cancer, transplant type, coagulation profile, date of operation and discharge, treatment, and other outpatient notes were collected and analyzed using the Chi-square test.
RESULTS: The majority of our patients undergoing allogeneic transplantation had leukemia and other types of anemia disorders including aplastic anemia, sickle cell anemia, and β-thalassemia (79%). However, the majority of patients undergoing autologous transplantation (73.4%) had lymphoma and other types of pathological disorders, including liver cell carcinoma, nephroblastoma, neuroblastoma, myelodysplastic syndromes, and primitive neuroectodermal tumors. Among patients with leukemia, anemia disorders, lymphoma, and other pathological disorders, 2.2%, 1.4%, 1.4%, and 2.8% suffered from thrombosis (overall, 1.9%) and 9.5%, 8.6%, 5.6%, and 11.2% suffered from bleeding, respectively (overall 8.9%). Moreover, the 7-year survival rate among those patients was 82.5%.
CONCLUSION: Bleeding occurred at a higher rate after HCT, and the overall 7-year survival rate was relatively high. |
| first_indexed | 2024-12-14T21:51:16Z |
| format | Article |
| id | doaj.art-4b659eeab45045e6bc1c4c63ff6eee3e |
| institution | Directory Open Access Journal |
| issn | 1658-5127 |
| language | English |
| last_indexed | 2024-12-14T21:51:16Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Applied Hematology |
| spelling | doaj.art-4b659eeab45045e6bc1c4c63ff6eee3e2022-12-21T22:46:14ZengWolters Kluwer Medknow PublicationsJournal of Applied Hematology1658-51272021-01-01121101610.4103/joah.joah_120_20Rates of bleeding, thrombosis, and survival in patients who underwent hematopoietic cell transplantation at king abdulaziz medical city, Riyadh, Saudi ArabiaSultan AlqahtaniAhmed AlrageaBasil AlqahtaniNawaf AlhoshanIbrahim AljasserAbdulaziz AlobaiedMohammed AlassiriEmad MasuadiMohsen AlzahraniBACKGROUND: Bleeding tendency and thrombosis are two major hematological complications observed in patients after hematopoietic cell transplantation (HCT). Although these complications are well reported in western communities, they are not well established in Saudi Arabia. OBJECTIVES: This retrospective study investigated the rates of bleeding, thrombosis, and survival in Saudi and non-Saudi patients who underwent HCT at King Abdulaziz Medical City, Riyadh, Saudi Arabia, from 2010 to 2017. METHODS AND MATERIALS: A total of 372 Saudi and non-Saudi patients of both sexes with leukemia, anemia disorders, lymphoma, and other types of pathological disorders who underwent autologous or allogeneic HCT were included in this study. Patient data including age, sex, nationality, type of cancer, transplant type, coagulation profile, date of operation and discharge, treatment, and other outpatient notes were collected and analyzed using the Chi-square test. RESULTS: The majority of our patients undergoing allogeneic transplantation had leukemia and other types of anemia disorders including aplastic anemia, sickle cell anemia, and β-thalassemia (79%). However, the majority of patients undergoing autologous transplantation (73.4%) had lymphoma and other types of pathological disorders, including liver cell carcinoma, nephroblastoma, neuroblastoma, myelodysplastic syndromes, and primitive neuroectodermal tumors. Among patients with leukemia, anemia disorders, lymphoma, and other pathological disorders, 2.2%, 1.4%, 1.4%, and 2.8% suffered from thrombosis (overall, 1.9%) and 9.5%, 8.6%, 5.6%, and 11.2% suffered from bleeding, respectively (overall 8.9%). Moreover, the 7-year survival rate among those patients was 82.5%. CONCLUSION: Bleeding occurred at a higher rate after HCT, and the overall 7-year survival rate was relatively high.http://www.jahjournal.org/article.asp?issn=1658-5127;year=2021;volume=12;issue=1;spage=10;epage=16;aulast=Alqahtanibleedingcancerhematopoietic cell transplantationsaudithrombosis |
| spellingShingle | Sultan Alqahtani Ahmed Alragea Basil Alqahtani Nawaf Alhoshan Ibrahim Aljasser Abdulaziz Alobaied Mohammed Alassiri Emad Masuadi Mohsen Alzahrani Rates of bleeding, thrombosis, and survival in patients who underwent hematopoietic cell transplantation at king abdulaziz medical city, Riyadh, Saudi Arabia Journal of Applied Hematology bleeding cancer hematopoietic cell transplantation saudi thrombosis |
| title | Rates of bleeding, thrombosis, and survival in patients who underwent hematopoietic cell transplantation at king abdulaziz medical city, Riyadh, Saudi Arabia |
| title_full | Rates of bleeding, thrombosis, and survival in patients who underwent hematopoietic cell transplantation at king abdulaziz medical city, Riyadh, Saudi Arabia |
| title_fullStr | Rates of bleeding, thrombosis, and survival in patients who underwent hematopoietic cell transplantation at king abdulaziz medical city, Riyadh, Saudi Arabia |
| title_full_unstemmed | Rates of bleeding, thrombosis, and survival in patients who underwent hematopoietic cell transplantation at king abdulaziz medical city, Riyadh, Saudi Arabia |
| title_short | Rates of bleeding, thrombosis, and survival in patients who underwent hematopoietic cell transplantation at king abdulaziz medical city, Riyadh, Saudi Arabia |
| title_sort | rates of bleeding thrombosis and survival in patients who underwent hematopoietic cell transplantation at king abdulaziz medical city riyadh saudi arabia |
| topic | bleeding cancer hematopoietic cell transplantation saudi thrombosis |
| url | http://www.jahjournal.org/article.asp?issn=1658-5127;year=2021;volume=12;issue=1;spage=10;epage=16;aulast=Alqahtani |
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