Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatment
<p>Abstract</p> <p>Background</p> <p>The aim of the study was to determine the most common pharmacological strategies used in the management of major depressive disorder (MDD) after an inadequate response to first-line antidepressant treatment in clinical practice.</...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-09-01
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| Series: | BMC Psychiatry |
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| Online Access: | http://www.biomedcentral.com/1471-244X/12/143 |
| _version_ | 1818142108784001024 |
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| author | Garcia-Toro Mauro Medina Esteban Galan Jaime L Gonzalez Miguel A Maurino Jorge |
| author_facet | Garcia-Toro Mauro Medina Esteban Galan Jaime L Gonzalez Miguel A Maurino Jorge |
| author_sort | Garcia-Toro Mauro |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The aim of the study was to determine the most common pharmacological strategies used in the management of major depressive disorder (MDD) after an inadequate response to first-line antidepressant treatment in clinical practice.</p> <p>Methods</p> <p>Multicenter, non-interventional study in adult outpatients with a DSM-IV-TR diagnosis of MDD and inadequate response to first-line antidepressant medication. Multiple logistic regression analyses were performed to identify independent factors associated with the adoption of a specific second-line strategy.</p> <p>Results</p> <p>A total of 273 patients were analyzed (mean age: 46.8 years, 67.8% female). Baseline mean Montgomery-Asberg Depression Rating Scale total score was 32.1 (95%CI 31.2-32.9). The most common strategies were: switching antidepressant medication (39.6%), augmentation (18.8%), and combination therapy (17.9%). Atypical antipsychotic drugs were the most commonly used agent for augmenting antidepressant effect. The presence of psychotic symptoms and the number of previous major depressive episodes were associated with the adoption of augmenting strategy (OR = 3.2 and 1.2, respectively).</p> <p>Conclusion</p> <p>The switch to another antidepressant agent was the most common second-line therapeutic approach. Psychiatrists chose augmentation based on a worse patients’ clinical profile (number of previous episodes and presence of psychotic symptoms).</p> |
| first_indexed | 2024-12-11T11:10:32Z |
| format | Article |
| id | doaj.art-4b67a7d7fc0a410e81cfc4ee71bc80c4 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-11T11:10:32Z |
| publishDate | 2012-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-4b67a7d7fc0a410e81cfc4ee71bc80c42022-12-22T01:09:33ZengBMCBMC Psychiatry1471-244X2012-09-0112114310.1186/1471-244X-12-143Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatmentGarcia-Toro MauroMedina EstebanGalan Jaime LGonzalez Miguel AMaurino Jorge<p>Abstract</p> <p>Background</p> <p>The aim of the study was to determine the most common pharmacological strategies used in the management of major depressive disorder (MDD) after an inadequate response to first-line antidepressant treatment in clinical practice.</p> <p>Methods</p> <p>Multicenter, non-interventional study in adult outpatients with a DSM-IV-TR diagnosis of MDD and inadequate response to first-line antidepressant medication. Multiple logistic regression analyses were performed to identify independent factors associated with the adoption of a specific second-line strategy.</p> <p>Results</p> <p>A total of 273 patients were analyzed (mean age: 46.8 years, 67.8% female). Baseline mean Montgomery-Asberg Depression Rating Scale total score was 32.1 (95%CI 31.2-32.9). The most common strategies were: switching antidepressant medication (39.6%), augmentation (18.8%), and combination therapy (17.9%). Atypical antipsychotic drugs were the most commonly used agent for augmenting antidepressant effect. The presence of psychotic symptoms and the number of previous major depressive episodes were associated with the adoption of augmenting strategy (OR = 3.2 and 1.2, respectively).</p> <p>Conclusion</p> <p>The switch to another antidepressant agent was the most common second-line therapeutic approach. Psychiatrists chose augmentation based on a worse patients’ clinical profile (number of previous episodes and presence of psychotic symptoms).</p>http://www.biomedcentral.com/1471-244X/12/143Major depressive disorderResponseAntidepressant treatmentAugmentationSwitchingCombination |
| spellingShingle | Garcia-Toro Mauro Medina Esteban Galan Jaime L Gonzalez Miguel A Maurino Jorge Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatment BMC Psychiatry Major depressive disorder Response Antidepressant treatment Augmentation Switching Combination |
| title | Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatment |
| title_full | Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatment |
| title_fullStr | Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatment |
| title_full_unstemmed | Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatment |
| title_short | Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatment |
| title_sort | treatment patterns in major depressive disorder after an inadequate response to first line antidepressant treatment |
| topic | Major depressive disorder Response Antidepressant treatment Augmentation Switching Combination |
| url | http://www.biomedcentral.com/1471-244X/12/143 |
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