| Summary: | Background: Intradialytic hypotension (IDH) is a critical pathological condition associated with all-cause mortality in patients undergoing hemodialysis (HD). However, few studies have investigated IDH-related changes in hepatic and cerebral regional tissue oxygen saturation (rSO<sub>2</sub>). This study investigated IDH-induced changes in hepatic and cerebral rSO<sub>2</sub>. Methods: Hepatic and cerebral rSO<sub>2</sub> during HD were measured using an INVOS 5100C oxygen saturation monitor, and their percentage (%) changes during the development of IDH were analyzed. Ninety-one patients undergoing HD were investigated, including twenty with IDH. Results: In patients with IDH, % changes in hepatic and cerebral rSO<sub>2</sub> decreased at the onset of IDH. Additionally, the % change in hepatic rSO<sub>2</sub> was significantly larger than that in cerebral rSO<sub>2</sub> (<i>p</i> < 0.001). In patients without IDH, no significant differences were found between the % changes in hepatic and cerebral rSO<sub>2</sub> at the time of the lowest systolic blood pressure during HD. Multivariable linear regression analysis showed that the difference between the % changes in cerebral and hepatic rSO<sub>2</sub> was significantly associated with the development of IDH (<i>p</i> < 0.001) and the ultrafiltration rate (<i>p</i> = 0.010). Conclusions: Hepatic and cerebral rSO<sub>2</sub> significantly decreased during the development of IDH, and hepatic rSO<sub>2</sub> was more significantly decreased than cerebral rSO<sub>2</sub> at the onset of IDH.
|
|---|