Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysis
BackgroundMild cognitive impairment (MCI) depicts a transitory phase between healthy elderly and the onset of Alzheimer's disease (AD) with worsening cognitive impairment. Some functional MRI (fMRI) research indicated that the frontoparietal network (FPN) could be an essential part of the patho...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1165908/full |
| _version_ | 1827915012250796032 |
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| author | Xinyi Yang Huimin Wu Yu Song Shanshan Chen Honglin Ge Zheng Yan Qianqian Yuan Xuhong Liang Xingjian Lin Jiu Chen Jiu Chen Jiu Chen |
| author_facet | Xinyi Yang Huimin Wu Yu Song Shanshan Chen Honglin Ge Zheng Yan Qianqian Yuan Xuhong Liang Xingjian Lin Jiu Chen Jiu Chen Jiu Chen |
| author_sort | Xinyi Yang |
| collection | DOAJ |
| description | BackgroundMild cognitive impairment (MCI) depicts a transitory phase between healthy elderly and the onset of Alzheimer's disease (AD) with worsening cognitive impairment. Some functional MRI (fMRI) research indicated that the frontoparietal network (FPN) could be an essential part of the pathophysiological mechanism of MCI. However, damaged FPN regions were not consistently reported, especially their interactions with other brain networks. We assessed the fMRI-specific anomalies of the FPN in MCI by analyzing brain regions with functional alterations.MethodsPubMed, Embase, and Web of Science were searched to screen neuroimaging studies exploring brain function alterations in the FPN in MCI using fMRI-related indexes, including the amplitude of low-frequency fluctuation, regional homogeneity, and functional connectivity. We integrated distinctive coordinates by activating likelihood estimation, visualizing abnormal functional regions, and concluding functional alterations of the FPN.ResultsWe selected 29 studies and found specific changes in some brain regions of the FPN. These included the bilateral dorsolateral prefrontal cortex, insula, precuneus cortex, anterior cingulate cortex, inferior parietal lobule, middle temporal gyrus, superior frontal gyrus, and parahippocampal gyrus. Any abnormal alterations in these regions depicted interactions between the FPN and other networks.ConclusionThe study demonstrates specific fMRI neuroimaging alterations in brain regions of the FPN in MCI patients. This could provide a new perspective on identifying early-stage patients with targeted treatment programs.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023432042, identifier: CRD42023432042. |
| first_indexed | 2024-03-13T02:52:22Z |
| format | Article |
| id | doaj.art-4b683d13fd264f6298d8bf3211f8040f |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-13T02:52:22Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-4b683d13fd264f6298d8bf3211f8040f2023-06-28T08:58:22ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-06-011510.3389/fnagi.2023.11659081165908Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysisXinyi Yang0Huimin Wu1Yu Song2Shanshan Chen3Honglin Ge4Zheng Yan5Qianqian Yuan6Xuhong Liang7Xingjian Lin8Jiu Chen9Jiu Chen10Jiu Chen11Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurosurgery, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurosurgery, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaInstitute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, ChinaMedical Imaging Center, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaBackgroundMild cognitive impairment (MCI) depicts a transitory phase between healthy elderly and the onset of Alzheimer's disease (AD) with worsening cognitive impairment. Some functional MRI (fMRI) research indicated that the frontoparietal network (FPN) could be an essential part of the pathophysiological mechanism of MCI. However, damaged FPN regions were not consistently reported, especially their interactions with other brain networks. We assessed the fMRI-specific anomalies of the FPN in MCI by analyzing brain regions with functional alterations.MethodsPubMed, Embase, and Web of Science were searched to screen neuroimaging studies exploring brain function alterations in the FPN in MCI using fMRI-related indexes, including the amplitude of low-frequency fluctuation, regional homogeneity, and functional connectivity. We integrated distinctive coordinates by activating likelihood estimation, visualizing abnormal functional regions, and concluding functional alterations of the FPN.ResultsWe selected 29 studies and found specific changes in some brain regions of the FPN. These included the bilateral dorsolateral prefrontal cortex, insula, precuneus cortex, anterior cingulate cortex, inferior parietal lobule, middle temporal gyrus, superior frontal gyrus, and parahippocampal gyrus. Any abnormal alterations in these regions depicted interactions between the FPN and other networks.ConclusionThe study demonstrates specific fMRI neuroimaging alterations in brain regions of the FPN in MCI patients. This could provide a new perspective on identifying early-stage patients with targeted treatment programs.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023432042, identifier: CRD42023432042.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1165908/fullactivation likelihood estimationamplitude of low-frequency fluctuationfrontoparietal networkfunctional connectivitymild cognitive impairmentregional homogeneity |
| spellingShingle | Xinyi Yang Huimin Wu Yu Song Shanshan Chen Honglin Ge Zheng Yan Qianqian Yuan Xuhong Liang Xingjian Lin Jiu Chen Jiu Chen Jiu Chen Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysis Frontiers in Aging Neuroscience activation likelihood estimation amplitude of low-frequency fluctuation frontoparietal network functional connectivity mild cognitive impairment regional homogeneity |
| title | Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysis |
| title_full | Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysis |
| title_fullStr | Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysis |
| title_full_unstemmed | Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysis |
| title_short | Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysis |
| title_sort | functional mri specific alterations in frontoparietal network in mild cognitive impairment an ale meta analysis |
| topic | activation likelihood estimation amplitude of low-frequency fluctuation frontoparietal network functional connectivity mild cognitive impairment regional homogeneity |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1165908/full |
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