Tumor-propagating side population cells are a dynamic subpopulation in undifferentiated pleomorphic sarcoma

Tumor-propagating side population cells are a dynamic subpopulation in undifferentiated pleomorphic sarcoma

Sarcomas contain a subpopulation of tumor-propagating cells (TPCs) with enhanced tumor-initiating and self-renewal properties. However, it is unclear whether the TPC phenotype in sarcomas is stable or a dynamic cell state that can derive from non-TPCs. In this study, we utilized a mouse model of und...

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Bibliographic Details
Main Authors: Yuning Jackie Tang, Vijitha Puviindran, Yu Xiang, Yasuhito Yahara, Hongyuan Zhang, Puviindran Nadesan, Yarui Diao, David G. Kirsch, Benjamin A. Alman
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-11-01
Series:JCI Insight
Subjects:
Oncology
Online Access:https://doi.org/10.1172/jci.insight.148768

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